Cytokine storms in severe influenza-related pneumonia
Project/Area Number |
23591151
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Osaka University |
Principal Investigator |
SEKI Masafumi 大阪大学, 医学部附属病院, 講師 (80432970)
|
Co-Investigator(Kenkyū-buntansha) |
TOMONO Kazunori 大阪大学, 医学部附属病院, 教授 (40202204)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 肺炎 / インフルエンザ / 好中球 / NETs / 次世代シークエンサー / NETs / MRSA / NHCAP / iインフルエンザ / 乳酸菌 |
Research Abstract |
In the basic research field, we analyzed the excessive immune responses, including apoptosis and NETs: neutrophil extracelluar traps, in both human pneuminia cases and mice models. In clinical research field, NHCAP: the nurshing and healthcare-associated pneumonia, cases were analyzed, and published the paper about therapeutic regimen and infection control for aspiration pneumonia in elderly persons and nosocomial pneumonia due to drug resistant pathogens, including MRSA.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system.2013
Author(s)
Seki M, Gotoh K, Nakamura S, Akeda Y, Yoshii T, Miyaguchi S, Inohara H, Horii T, Oishi K, Iida T, Tomono K,
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Journal Title
J Med Microbiol
Volume: 62
Pages: 801-803
Related Report
Peer Reviewed
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[Journal Article] TLR4 agonistic antibody promotes innate immunity against severe pneumonia induced by co-infection with influenza virus and Streptococcus pneumoniae2013
Author(s)
7) Tanaka A, Nakamura S, Seki M, Fukudome K, Iwanaga N, Imamura Y, Miyazaki T, Izumikawa K, Kakeya H, Yanagihara K, and Kohno S.
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Journal Title
Clinical and Vaccine Immunology
Volume: 20
Pages: 977-985
Related Report
Peer Reviewed
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[Journal Article] Characteristics and disease severity of healthcare-associated pneumonia among patients in a hospital in Kitakyusyu, Japan.2011
Author(s)
Seki M, Hashiguchi K, Tanaka A, Kosai K, Kakugawa T, Awaya K, Kurihara S, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Tashiro T, Kohno S.
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Journal Title
J Infect Chemother.
Volume: 17
Pages: 363-369
Related Report
Peer Reviewed
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[Journal Article] Time course analysis of apoptosis in a murine model of severe pneumococcal pneumonia during influenza A virus infection.2011
Author(s)
Kosai K, Seki M, Tanaka A, Morinaga Y, Kurihara S, Miyazaki T, Izumikawa K, Kakeya H, Yamamoto Y, Yanagihara K, Yasuoka A, Tomono K, Tashiro T, Kohno S.
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Journal Title
Jpn J Infect Dis.
Volume: 64
Pages: 451-457
Related Report
Peer Reviewed
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