A novel protective strategy for Pseudomonas aeruginosa infection-Development of vaccine using pilus peptide
| Project/Area Number |
23591152
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIRAMATSU Kazufumi 大分大学, 医学部, 准教授 (80301381)
SHIRAI Ryo 大分大学, 医学部, 助教 (60437837)
KISHI Kenji 大分大学, 医学部, 助教 (20347024)
ISHII Hiroshi 大分大学, 医学部, 助教 (60398146)
TOKIMATSU Issei 大分大学, 医学部, 講師 (20347032)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 緑膿菌線毛蛋白 / ペプチド / 樹状細胞 / ワクチン / 緑膿菌線毛 |
|---|
| Research Abstract |
Murine naive T cells were incubated with mature dendritic cells stimulated by pili of Pseudomonas aeruginosa or by its peptide. The concentration of cytokines in the culture supernatant stimulated with pili or peptide increased compared to that in control and naive T cells proliferated to mature ones. This result indicates that adaptive immunity by pili but less peptide occurred through dendritic cells. In the future, the efficacy of vaccine by inoculation of pili- or peptide-stimulated mature dendritic cells into mouse should be investigated.
|
Report
(4 results)
Research Products
(8 results)
-
[Presentation] 樹状細胞を介した緑膿菌線毛蛋白ワクチンの可能性の検討2013
Author(s)
橋永一彦,横山敦,吉川裕喜,岡宏亮,串間尚子,甲斐直子,鳥羽聡史,石井寛,白井亮,岸建志,時松一成,平松和史,門田淳一
Organizer
第87回日本感染症学会学術講演会・日本化学療法学会総会合同学会
Place of Presentation
横浜
Related Report
-
-
[Presentation] 樹状細胞を介した緑膿菌線毛蛋白ワクチンの可能性の検討2012
Author(s)
橋永一彦,横山敦,吉川裕喜,岡宏亮,串間尚子,甲斐直子,鳥羽聡史,石井寛,白井亮,岸建志,時松一成,平松和史,門田淳一
Organizer
第60回日本化学療法学会西日本支部総会,第55回日本感染症学会中日本地方学術集会,第82回日本感染症学会西日本地方学術集会
Place of Presentation
福岡
Related Report
-
[Presentation] 樹状細胞を介した緑膿菌線毛蛋白ペプチドによるワクチンの可能性の検討2012
Author(s)
橋永一彦,横山敦,岡宏亮,串間尚子,吉岡大介,大谷哲史,鳥羽聡史,梅木健二,石井寛,白井亮,岸建志,時松一成,平松和史,門田淳一
Organizer
第86回日本感染症学会学術講演会
Place of Presentation
長崎
Related Report
-
-
-
[Presentation] 特異的免疫誘導因子としての緑膿菌線毛蛋白構成ペプチドの機能解析2011
Author(s)
橋永一彦,岩田敦子,園田尚子,大谷哲史,吉岡大介,梅木健二,石井寛,岸建志,白井亮,時松一成,平松和史,門田淳一
Organizer
第85回日本感染症学会総会学術講演会
Place of Presentation
東京
Related Report
-
