Clinical application of apotosis-inducible factor for inflammatory cells from patients with idiopathic pulmonary fibrosis
| Project/Area Number |
23591153
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮崎 英士 大分大学, 医学部, 教授 (00264333)
石井 稔浩 大分大学, 医学部, 助教 (00528911)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAZAKI Eishi 大分大学, 医学部, 教授 (00264333)
ISHII Toshihiro 大分大学, 医学部, 教授 (00528911)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 特発性肺線維症 / 炎症細胞 / アポトーシス |
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| Research Abstract |
RCAS1 levels in the bronchoalveolar lavage fluid (BALF) were significantly higher in patients with idiopathic pulmonary fibrosis (IPF) than in controls. Immunohistochemistry revealed RCAS1 expression in alveolar macrophages, type II alveolar epithelial cells, T-lymphocytes in lymphoid follicle, B-lymphocytes around lymphoid follicles, fibroblast in fibroblastic foci in the lung specimen from patients with IPF. Serum levels of RAS1 in patients with IPF were significantly higher than healthy volunteers. Serum levels of RCAS1 were correlated with the BALF levels of RCAS1. Serum RCAS1 concentrations were correlated with percent predicted forced vital capacity from patients with IPF.
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Report
(4 results)
Research Products
(2 results)
