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Involvement of bone marrow-derived fibrocyte in the pathogenesis of pulmonary fibrosis and the effect of newly developed anti-fibrotic agents

Research Project

Project/Area Number 23591163
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

AZUMA Arata  日本医科大学, 医学部, 教授 (10184194)

Co-Investigator(Kenkyū-buntansha) 神尾 孝一郎  日本医科大学, 医学部, 助教 (20465305)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords特発性肺線維症 / 線維細胞 / ピルフェニドン / fibrocyte
Research Abstract

Bone marrow-derived fibrocytes reportedly play important roles in the pathogenesis of idiopathic pulmonary fibrosis. Pirfenidone (PFD) is an anti-fibrotic agent; however, its effects on fibrocytes have not been investigated. The aim of this study was to investigate whether PFD inhibits fibrocyte pool size in the lungs of bleomycin (BLM)-treated mice. To achieve this, C57BL/6 mice were treated with BLM and PFD was administered. Fibrocyte pool size in BLM-treated mice lungs was attenuated by PFD. This was also observed in a therapeutic setting. Increased chemokine (CC motif) ligand-2 (CCL2) and CCL12 production in BLM-treated mouse lungs was significantly attenuated by PFD. Fibrocyte migration toward CCL2 and chemokine (CC motif) receptor-2 expression on fibrocytes were significantly inhibited by PFD in vitro. Fibrocyte inhibition is considered a mechanism of anti-fibrotic action of PFD.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis2014

    • Author(s)
      Minoru Inomata, Koichiro Kamio, Arata Azuma, Kuniko Matsuda, Nariaki Kokuho, Yukiko Miura, Hiroki Hayashi, Takahito Nei, Kazue Fujita, Yoshinobu Saito and Akihiko Gemma
    • Journal Title

      Respiratory Research

      Volume: 15巻 Issue: 1 Pages: 16-30

    • DOI

      10.1186/1465-9921-15-16

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Pirfenidone Inhibits Bone Marrow-Derived Fibrocytes Influx Into The Lungs In Bleomycin-Induced Murine Pulmonary Fibrosis2013

    • Author(s)
      Minoru Inomata, Koichiro Kamio, Kuniko Matsuda, Nariaki Kokuho, Yukiko Miura, Kazue Fujita, Yoshinobu Saito, Akihiko Gemma, Arata Azuma
    • Organizer
      American Thoracic Society Conference 2013
    • Year and Date
      2013-05-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ブレオマイシン誘発肺障害モデルマウスにおけるピルフェニドンの骨髄由来fibrocyte抑制効果に関する検討2013

    • Author(s)
      猪俣稔、神尾孝一郎、松田久仁子、國保成暁、根井貴仁、三浦由記子、藤田和恵、齋藤好信、弦間昭彦、吾妻安良太
    • Organizer
      第53回日本呼吸域学会学術講演会
    • Year and Date
      2013-04-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ブレオマイシン誘発肺障害モデルマウスにおけるピルフェニドンの骨髄由来fibrocyte抑制効果に関する検討2013

    • Author(s)
      猪俣稔、神尾孝一郎、松田久仁子、國保成暁、根井貴仁、三浦由記子、藤田和恵、齋藤好信、弦間昭彦、吾妻安良太
    • Organizer
      第53回 日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pirfenidone Inhibits Bone Marrow-Derived Fibrocytes Influx into the Lungs in Bleomycin-induced Murine Pulmonary Fibrosis2013

    • Author(s)
      Minoru Inomata, Koichiro Kamio, Kuniko Matsuda, Nariaki Kokuho, Yukiko Miura, Kazue Fujita, Yoshinobu Saito, Akihiko Gemma, Arata Azuma
    • Organizer
      American Thoracic Society
    • Place of Presentation
      米国フィラデルフィア
    • Related Report
      2013 Annual Research Report
  • [Presentation] ブレオマイシン誘発肺障害モデルマウスにおけるピルフェニドンの骨髄由来fibrocyte抑制効果に関する検討

    • Author(s)
      猪俣稔、神尾孝一郎、吾妻安良太
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Pirfenidone Inhibits Bone Marrow-Derived Fibrocytes Influx into the Lungs In Bleomycin-induced Murine Pulmonary Fibrosis

    • Author(s)
      猪俣稔、神尾孝一郎、吾妻安良太
    • Organizer
      American Thoracic Society
    • Place of Presentation
      米国
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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