| Project/Area Number |
23591164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERASAKI Yasuhiro 日本医科大学, 医学部, 准教授 (50332870)
福田 悠 日本医科大学, 医学(系)研究科(研究院), 教授 (60097037)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGASAKA Shinya 日本医科大学, 医学部, 助教 (00573239)
MIYAKE Kouichi 日本医科大学, 医学部, 准教授 (90267211)
TAKAHASHI Mikiko 日本医科大学, 医学部, 助教 (40516077)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 間質性肺炎 / 肺胞上皮 / miRNA / microRNA / exosome / multivesicular body / 血管新生 / 血管新生抑制薬 |
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| Research Abstract |
We have been investigated pathogenesis of early intra-alveolar fibrotic process in interstitial pneumonia. We showed fibroblast differentiation into myofibroblast and decreased neovasculization in intra-alveolar fibrotic lesion of idiopathic pulmonary fibrosis. However, there is only limited information concerning the role of miroRNA in lung fibrotic process. Forthermore, microRNA and exosomal microRNA in bronchoalveolar lavage in lung fibrotic process are not investigated. We investigate exosomal microRNA in brochoalveolar lavage flood in mouse model of bleomycin induced lug fibrosis.
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