Pathogenesis of interstitial pneumonia caused by abnormal transport of lung surfactant
Project/Area Number |
23591165
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Kanazawa Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
IGUCHI Masaharu 金沢医科大学, 医学部, 助教 (60350758)
KOBAYASHI Makoto 金沢医科大学, 医学部, 助教 (20460355)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 間質性肺炎 / 肺サーファクタント / 細胞内輸送 / 肺胞上皮細胞 / ヘルマンスキー・パドラック症候群 / Rab38低分子量Gタンパク質 / ヘルマンスキーパドラック症候群 / 肺胞II型上皮細胞 / 肺胞II型上皮細胞 / 細胞内輸送異常 |
Research Abstract |
To investigate pathogenesis of interstitial pneumonia that is caused by perturbation of lung surfactant transport, we analyzed the lungs of Long Evans Cinnamon rats, an animal model of Hermansky-Pudlak syndrome. There were remarkably enlarged giant lamellar bodies and increased lung surfactant in alveolar type II cells. Basal secretion of surfactant from the cells was inhibited but agonist-induced secretion was reversely enhanced. Adenovector-mediated delivery of Rab38 ameliorated these surfactant abnormalities. Unexpectedly, the rat lungs showed emphysematous changes. It is suspected that complication with infection, air pollution, and/or aging would be necessary in addition to a primary genetic abnormality to develop interstitial pneumonia in the disease.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] A three-microphone acoustic reflection technique using transmitted acoustic waves in the airway2013
Author(s)
Fujimoto Y, Huang J, Fukunaga T, Kato R, Higashino M, Shinomiya S, Kitadate S, Takahara Y, Yamaya A, Saito M, Kobayashi M, Kojima K, Oikawa T, Nakagawa K, Tsuchihara K, Iguchi M, Takahashi M, Mizuno S, Osanai K, Toga H.
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Journal Title
J Appl Physiol
Volume: 115
Issue: 8
Pages: 1119-1125
DOI
Related Report
Peer Reviewed
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