| Project/Area Number |
23591166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
MARUYAMA Junko 鈴鹿医療科学大学, 医用工学部, 教授 (50263017)
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| Co-Investigator(Kenkyū-buntansha) |
KATO Takuma 三重大学, 大学院医学系研究科免疫学, 準教授 (60224515)
MARUYAMA Kazuo 三重大学, 大学院医学系研究科麻酔集中治療学, 教授 (20181828)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 低酸素 / 筋性化 / 右室肥大 / 右室収縮期圧 / 低酸素暴露 / 肺高血圧 / IL17 |
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| Research Abstract |
To investigate whether IL17A is associated with the development of hypoxia-induced pulmonary hypertension (PH), C57B6 wild type (WT) and IL17A-deficient (KO) mice were exposed to hypobaric hypoxia (hypo) for up to 42 days. The degree
of right ventricle systolic pressure (RVSP) and right ventricular hypertrophy (RVH), and percentages of muscularized peripheral vessels (%muscularity) were increased in WT/hypo group compared with WT control group after 21-day hypoxia. No difference was observed in RVSP, RVH between KO/hypo and WT/hypo group. There was slight decrease in %muscularity in KO/hypo group compared with that in WT/hypo group. Inflammatory cytokines were increased in the development process of PH in WT/hypo group, whereas, anti-inflammatory cytokines were increased in KO/hypo group compared with WT/hypo group. In conclusion, IL17A might be associated with the progression of hypoxic PH, however, additional studies are necessary in order to be elucidated.
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