Developmental reserch of the novel therapy for intractable pulmonary diseases such as pulmonary fibrosis

• Project/Area Number: 23591167
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: TABATA Chiharu 兵庫医科大学, 医学部, 准教授 (90432393)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: バイオマーカー / サイトカイン / 酸化ストレス / 間質性肺炎 / 血管新生 / レチノイド / サリドマイド / 中皮腫 / 慢性閉塞性肺疾患

Research Abstract

Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very important. We demonstrated that patients with MPM had significantly higher serum levels of some markers such as HMGB1, thioredoxin, angiopoietin-1 than the population who had been exposed to asbestos but had not developed MPM. The difference in overall survival between groups with serum HMGB1 and angiopoietin-1 levels that were lower and higher than assumed cut-off values was significant.
Our data suggest that serum HMGB1, thioredoxin and angiopoietin-1 concentrations are useful clinical markers for MPM.

Research Products

• [Journal Article] CD2-positive follicular lymphoma complicated by venous thrombus of surface vein (2014)
  • Author(s): Tabata R, Tabata C, Goto T, Yasumizu R, Kojima M.
  • Journal Title: Ann Hematol Volume: 93(3) Issue: 3 Pages: 517-9
  • DOI: 10.1007/s00277-013-1824-z
  • Peer Reviewed
• [Journal Article] Clinical significance of serum angiopoietin-1 in malignant peritoneal mesothelioma. (2013)
  • Author(s): Mikami K, Tabata C, et al.
  • Journal Title: Cancer Invest. Volume: 31 Issue: 8 Pages: 511-5
  • DOI: 10.3109/07357907.2013.830734
  • Peer Reviewed
• [Journal Article] Serum HMGB1 as a diagnostic marker for malignant peritoneal mesothelioma (2013)
  • Author(s): Tabata C, Kanemura S, Tabata R, Masachika E, Shibata E, Otsuki T, Nishizaki T, Nakano T.
  • Journal Title: J Clin Gastroenterol Volume: 47 Issue: 8 Pages: 684-8
  • DOI: 10.1097/mcg.0b013e318297fa65
  • Peer Reviewed
• [Journal Article] Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma. (2013)
  • Author(s): TabataC, et al.
  • Journal Title: BMC Cancer Volume: 13 Issue: 1 Pages: 205-205
  • DOI: 10.1186/1471-2407-13-205
  • Peer Reviewed
• [Journal Article] Double-hit lymphoma demonstrating t(6;14;18)(p25;q32;q21), suggesting two independent dual-hit translocations, MYC/BCL-2 and IRF4/BCL-2 (2013)
  • Author(s): Tabata R, Yasumizu R, Tabata C, Kojima M.
  • Journal Title: J Clin Exp Hematop Volume: 53(2) Pages: 141-50
  • Peer Reviewed
• [Journal Article] Effect of cyclosporine on lymphocytic variant hypereosinophilic syndrome (2013)
  • Author(s): Tabata R, Tabata C, Katashima Y, Yasumizu R.
  • Journal Title: Int Immunopharmacol Volume: 16 Issue: 4 Pages: 488-91
  • DOI: 10.1016/j.intimp.2013.04.033
  • Peer Reviewed
• [Journal Article] Management of myocardial infarction in immune thrombocytopenic purpura with anti-phospholipid antibodies (2013)
  • Author(s): Tabata R, Tabata C, Kita Y.
  • Journal Title: J Thromb Thrombolysis Volume: 35 Issue: 1 Pages: 115-8
  • DOI: 10.1007/s11239-012-0763-1
  • Peer Reviewed
• [Journal Article] Serum thioredoxin-1 as a diagnostic marker for malignant peritoneal mesothelioma. (2013)
  • Author(s): Tabata C, et al.
  • Journal Title: J Clin Gastroenterol Volume: 47 Issue: 1 Pages: e7-e11
  • DOI: 10.1097/mcg.0b013e31824e901b
  • Peer Reviewed
• [Journal Article] Serum thioredoxin-1 as a diagnostic marker for malignant peritoneal mesothelioma. (2013)
  • Author(s): Tabata C, Terada T, Tabata R, et al.
  • Journal Title: J Clin Gastroenterol. Volume: 47 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Management of myocardial infarction in immune thrombocytopenic purpura with anti-phospholipid antibodies. (2013)
  • Author(s): Tabata R, Tabata C, Kita Y.
  • Journal Title: J Thromb Thrombolysis. Volume: 35 Pages: 115-8
  • Peer Reviewed
• [Journal Article] Clinical utility of 18-fluorodeoxyglucose positron emission tomography/computed tomography in malignant pleural mesothelioma (2012)
  • Author(s): Terada T, Tabata C, Tabata R, Okuwa H, Kanemura S, Shibata E, Nakano T.
  • Journal Title: Exp Ther Med. Volume: 4 Pages: 197-200
  • Peer Reviewed
• [Journal Article] Nodal marginal zone B cell lymphoma with prominent follicular colonization with deletion of chromosome 13 (2012)
  • Author(s): Tabata R, Tabata C, Nagai T, Yasumizu R, Kojima M.
  • Journal Title: Pathol Res Pract Volume: 208 Issue: 11 Pages: 679-82
  • DOI: 10.1016/j.prp.2012.07.009
  • Peer Reviewed
• [Journal Article] Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma (2012)
  • Author(s): Murakami A, Tabata C, Tabata R, Okuwa H, Nakano T.
  • Journal Title: Oncol Lett. Volume: 3 Pages: 581-585
  • Peer Reviewed
• [Journal Article] Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma (2012)
  • Author(s): Tabata R, Tabata C, Tazoh A, Nagai T.
  • Journal Title: Int Immunopharmacol Volume: 13 Issue: 3 Pages: 242-4
  • DOI: 10.1016/j.intimp.2012.04.015
  • Peer Reviewed
• [Journal Article] Deficiency of Fyn protein is prerequisite for apoptosis induced by Src family kinase inhibitors in human mesothelioma cells (2012)
  • Author(s): Eguchi R, Kubo S, Takeda H, Ogawa H, et al.(8人中6番)
  • Journal Title: Carcinogenesis Volume: 33 Issue: 5 Pages: 969-975
  • DOI: 10.1093/carcin/bgs109
  • Peer Reviewed
• [Journal Article] Heme oxygenase-1 promoter polymorphism is associated with risk of malignant mesothelioma (2012)
  • Author(s): Murakami A, Fujimori Y, Yoshikawa Y, Yamada S, Tamura K, Hirayama N, Terada T, Kuribayashi K, Tabata C, Fukuoka K, Tamaoki T, Nakano T.
  • Journal Title: Lung. Volume: 190 Issue: 3 Pages: 333-7
  • DOI: 10.1007/s00408-012-9371-2
  • Peer Reviewed
• [Journal Article] Follicular lymphoma with prominent fibrosis complicated by peripheral eosinophilia (2012)
  • Author(s): Tabata R, Tabata C, Nagai T, Yasumizu R.
  • Journal Title: Ann Hematol Volume: 91 Issue: 6 Pages: 965-7
  • DOI: 10.1007/s00277-011-1342-9
  • Peer Reviewed
• [Journal Article] Possible prediction of underlying lymphoma by high sIL-2R/ferritin ratio in hemophagocytic syndrome (2012)
  • Author(s): Tabata C, Tabata R.
  • Journal Title: Ann Hematol Volume: 91 Issue: 1 Pages: 63-71
  • DOI: 10.1007/s00277-011-1239-7
  • Peer Reviewed
• [Journal Article] Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma. (2012)
  • Author(s): Murakami A, Tabata C, Tabata R, et al.
  • Journal Title: Oncol Lett. Volume: 3 Pages: 581-585
  • Peer Reviewed
• [Journal Article] Clinical utility of 18-fluorodeoxyglucose positron emission tomography/computed tomography in malignant pleural mesothelioma. (2012)
  • Author(s): Terada T, Tabata C, Tabata R, et al.
  • Journal Title: Exp Ther Med. Volume: 4 Pages: 197-200
  • Peer Reviewed
• [Journal Article] Nodal marginal zone B cell lymphoma with prominent follicular colonization with deletion of chromosome 13. (2012)
  • Author(s): Tabata R, Tabata C, Nagai T, et al.
  • Journal Title: Pathol Res Pract. Volume: 208 Pages: 679-82
  • Peer Reviewed
• [Journal Article] Low dose cepharanthine ameliorates immune thrombocytopenic purpura associated with multiple myeloma. (2012)
  • Author(s): Tabata R, Tabata C, Tazoh A, et al.
  • Journal Title: Int Immunopharmacol. Volume: 13 Pages: 242-4
  • Peer Reviewed
• [Journal Article] Follicular lymphoma with prominent fibrosis complicated by peripheral eosinophilia. (2012)
  • Author(s): Tabata R, Tabata C, Nagai T, et al.
  • Journal Title: Ann Hematol. Volume: 91 Pages: 965-7
  • Peer Reviewed
• [Journal Article] Clinical role of pleural effusion MMP-3 levels in malignant pleural mesothelioma (2012)
  • Author(s): Murakami A, Tabata C, Tabata R, et al.
  • Journal Title: Oncology Letters Volume: 3 Pages: 581-5
  • Peer Reviewed
• [Journal Article] Pleural effusion VEGF levels as a prognostic factor of malignant pleural mesothelioma. (2011)
  • Author(s): Hirayama N, Tabata C, Tabata R, et al.
  • Journal Title: Respir Med Volume: 105 Pages: 137-42
  • Peer Reviewed
• [Journal Article] C reactive protein as a predictor of neutrophil recovery in autoimmune neutropenia. (2011)
  • Author(s): Tabata C, Tabata R, Kitai H, et al.
  • Journal Title: Int Immunopharmacol Volume: 11 Pages: 774-7
  • Peer Reviewed
• [Journal Article] Is serum thioredoxin-1 a useful clinical marker for malignant pleural mesothelioma? (2011)
  • Author(s): Maeda R, Tabata C, Tabata R, et al.
  • Journal Title: Antioxid Redox Signal Volume: 15 Pages: 685-9
  • Peer Reviewed
• [Journal Article] Clinical significance of pleural effusion mesothelin in malignant pleural mesothelioma. (2011)
  • Author(s): Yamada S, Tabata C, Tabata R, et al.
  • Journal Title: Clin Chem Lab Med Volume: 49 Pages: 1721-6
  • Peer Reviewed
• [Journal Article] Prominent granulomas in bone marrow in disseminated lymphoma with hemophagocytic syndrome. (2011)
  • Author(s): Tabata R, Tabata C, Kimura T, et al.
  • Journal Title: Ann Hematol. Volume: 90 Pages: 1365-7
  • Peer Reviewed
• [Journal Article] 肺線維症に対するcalpainの可能性． (2011)
  • Author(s): 田端千春
  • Journal Title: リウマチ科 Volume: 46 Pages: 174-9
• [Presentation] A novel clinical role for angiopoietin-1 malignant pleural mesothelioma. (2013)
  • Author(s): Tabata C, et al.
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
• [Presentation] The Calpain inhibitor Calpeptin Prevents Bleomycin-Induced Pulmonary Fibrosis in Mice. (2013)
  • Author(s): Tabata C, et al.
  • Organizer: 18th Congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Yokohama
• [Presentation] The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. (2011)
  • Author(s): Tabata C, Tabata R, Maeda R, et al.
  • Organizer: American College of Chest Physician(Chest 2011)
  • Place of Presentation: Honolulu