| Project/Area Number |
23591172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MORIMOTO Yasuo 産業医科大学, 産業生態科学研究所, 教授 (30258628)
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| Co-Investigator(Kenkyū-buntansha) |
IZUMI Hiroto 産業医科大学, 産業生態科学研究所, 准教授 (50289576)
黒田 悦史 大阪大学, 学内共同利用施設等, 准教授 (10299604)
堀江 祐範 産業医科大学, 産業生態科学研究所, 助教 (30514591)
神原 辰徳 産業医科大学, 産業生態科学研究所, その他 (50596450)
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| Co-Investigator(Renkei-kenkyūsha) |
KURODA Etsushi 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (10299604)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | レゴリス / 気管内注入 / CINC / 肺 / 好中球 |
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| Research Abstract |
We estimated the harmfulness of moon dust (regolith) to perform the intratracheal instillation study of moon simulant dust. The particle with 10um (ground gravity) and 24.5um (moon gravity) of aerodynamic diameter were classified by gravitational liquid sedimentation methods. We intratracheally exposed rats at 1mg or 2mg of the simulant dust, and examined the pulmonary response. In ground gravity's particle-exposed rat, the infiltration mainly on neutrophils was observed accompanied with elevation of gene of CINC, and this response gradually returned to control level over time. In moon gravity's particle-exposed rat, the neutrophil infiltration and elevation of gene expression of CINC in early stage was observed, and this response gradually disappeared. Taken together, the pulmonary inflammatory responses of particles which was made under the ground were similar to ones under the moon gravity, suggesting that gravity may not affect potential of dust on severe pulmonary inflammation.
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