|Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|Outline of Final Research Achievements
Lung cancer tissue and normal bronchial tissue were obtained from surgically resected lung specimens of 29 patients with lung cancer (19 male, mean age 68.8 years, 21 adenocarcinoma and 8 squamous carcinoma). Uptake experiments of the fluorescent D-Ala-Lys-AMCA which is identified as peptide transporter substrate for peptide transporter (PEPT2) showed higher tendency of accumulated fluorescence intensity in the squamous cell carcinoma tissue compaired to adenocarcinoma (p=0.09). Positive staining of immunohistochemistry for PEPT2 showed in both cancer tissues and normal bronchial tissues. Quantitatively, mRNA levels of PEPT2 were significantly higher in the squamous cell carcinoma tissues compaired to adenocarcinoma (p=0.038).