Analysis of activation of glomerular parietal epithelial cells to podocyte injury
| Project/Area Number |
23591176
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
SASAKI Satoshi 北海道大学, 医学(系)研究科(研究院), 客員研究員 (70312345)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糸球体硬化症 / 慢性腎疾患 / 糸球体上皮細胞 / 腎臓学 / ネフローゼ症候群 / 巣状分節性糸球体硬化症 |
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| Research Abstract |
Recent investigations have disclosed that activation of parietal epithelial cells (PECs) plays key roles in the process of focal segmental glomerulosclerosis (FSGS). In this experimental project, we have tried to investigate dynamic behavior of activated PECs in the evolution of FSGS. We conducted serial assessment of activated PECs using the mouse models of lipopolysaccharide(LPS)-induced proteinuria and adriamycin (ADR) nephrosis. To further analyze the role of activated PECs, we induced rapid progressive podocytopathy using LPS-treated ADR nephrosis mice. As the cell markers for activation, we utilized two markers , CD44 and CXCR4. Using models of ADR nephrosis in mice of different ages, we found that CD44+PECs play significant roles in progressive glomerulosclerosis and the prevalence of the cells reflects different degrees of podocyte injury. In addition, analysis of two different markers for PEC activation clarified different roles of these markers during cell activation process.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis.2013
Author(s)
Miura K, Kurihara H, Horita S, Chikamoto H, Hattori M, Harita Y, Tsurumi H, Kajiho Y, Sawada Y, Sasaki S, Igarashi T, Kunishima S, Sekine T.
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Journal Title
Nephrol Dial Transplant.
Volume: 28
Issue: 12
Pages: 2993-3003
DOI
Related Report
Peer Reviewed
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[Journal Article] for the Japanese Study Group of Renal Disease in Children. Two-Year Follow-Up of a Prospective Clinical Trial of Cyclosporine for Frequently Relapsing Nephrotic Syndrome in Children.2012
Author(s)
Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ito S, Yata N, Ando T, Honda M
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Journal Title
Clin J Am Soc Nephrol
Volume: 7
Issue: 10
Pages: 1576-1583
DOI
Related Report
Peer Reviewed
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