New cell therapy for kidney disease using human kidney derived iPS cells

• Project/Area Number: 23591184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: The University of Tokyo
• Principal Investigator: YOSHIKAWA Masahiro 東京大学, 医学部附属病院, 研究員 (20447410)
• Co-Investigator(Kenkyū-buntansha): HISHIKAWA Keiichi 東京大学, 大学院医学研究科, 特任准教授 (50255460)
• Co-Investigator(Renkei-kenkyūsha): FUJITA Toshiro 東京大学, 先端研, 特任教授 (10114125) ; ABRATANI Hiroyuki 東京大学, 先端研, 教授 (10202657)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: iPS 細胞 / 腎臓 / 再生医学 / iPS細胞 / 再生 / 再生医療 / メチル化

Outline of Final Research Achievements

Human pluripotent cells are promising for treatment for kidney diseases, but the protocols for derivation of kidney cell types are still controversial. In this study, we tried to establish new cell therapy for kidney disease by using human kidney derived iPS cells. We induced kidney lineage cells from iPS cells and confirmed improvement of kidney function by using the cells.

Research Products

• [Journal Article] Basichelix-loop-helix transcriptional factor MyoR regulates BMP-7 in acute kidney injury. (2013)
  • Author(s): Kamiura N, Hirahashi J, Matsuzaki Y, Idei M, Takase O, Fujita T, TakatoT, Hishikawa K.
  • Journal Title: Am J Physiol RenalPhysiol. Volume: 304(9) Issue: 9 Pages: 2493-2500
  • DOI: 10.1152/ajprenal.00510.2012
  • Peer Reviewed
• [Journal Article] The role of NF-κB signaling in the maintenance of pluripotency of human induced pluripotent stem cells (2013)
  • Author(s): Takase O, Yoshikawa M, Idei M, Hirahashi J, Fujita T, Takato T, Isagawa T, Nagae G, Suemori H, Aburatani H, Hishikawa K
  • Journal Title: PLoS One Volume: 8(2) Issue: 2 Pages: e56399-e56399
  • DOI: 10.1371/journal.pone.0056399
  • Peer Reviewed
• [Presentation] 腎臓由来iPS細胞を用いた2つの腎系統特異的分化誘導法の検討 (2015)
  • Author(s): 高瀬 敦、辻村太郎、出射真奈、宮本寛治、吉川真弘、南学正臣、高戸毅、菱川慶一
  • Organizer: 第１４回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-03-19 – 2015-03-21
• [Presentation] 腎系統特異的分化刺激を用いた腎上皮細胞由来iPS細胞の検討 (2014)
  • Author(s): 高瀬 敦、吉川真弘、高戸毅、南学正臣、菱川慶一
  • Organizer: 第５７回日本腎臓学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] ヒト腎臓由来iPS細胞のDNAメチル化プロファイルと細胞記憶 (2011)
  • Author(s): 菱川慶一、高瀬敦、吉川真弘、出射真奈、藤田敏郎
  • Organizer: 日本腎臓学会
  • Place of Presentation: 東京