| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
We have previously found that SV2B is one of the critical molecules in maintaining the podocyte function. The study with several experimental models revealed that SV2B could be an early sensitive marker to detect podocyte injury. This study also revealed that the podocyte injury caused by the stimulation to the extracellular site of nephrin was p38MAPK dependent, and that p38MAPK inhibitor ameliorated proteinuria in this podocyte injury. We observed that p38MAPK inhibitor prevented the decrease in the expression of slit diaphragm molecules, nephrin and podocin, which is detect at the early phase of this podocyte injury. Besides, in this project we established the novel assay system to semi-quantitatively analyze the effect of reagents to glomerular permeability barrier with isolated glomeruli.
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