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New responsible genes for CAKUT and development of comprehensive gene mutation detection system in CAKUT

Research Project

Project/Area Number 23591192
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKobe University

Principal Investigator

IIJIMA Kazumoto  神戸大学, 医学(系)研究科(研究院), 教授 (00240854)

Co-Investigator(Kenkyū-buntansha) 長田 道夫  筑波大学, 人間総合科学研究科, 教授 (10192238)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎尿路奇形 / 原因遺伝子
Research Abstract

We utilized the genome-wide array CGH and the next generation sequencing to identify new responsible copy number variations or gene mutations. We found that deletions in the region of 1q21.1, 16q12.1q12.2, 16q12.1q13 and 8q12.1q12.3, and mutations of the UPK3A gene and EP300 gene may cause CAKUT. We also developed the comprehensive detection system of gene mutations and copy number variations responsible for CAKUT.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (99 results)

All 2014 2013 2012 2011

All Journal Article (59 results) (of which Peer Reviewed: 17 results) Presentation (31 results) (of which Invited: 2 results) Book (9 results)

  • [Journal Article] Natural history of genetically proven autosomal recessive Alport syndrome2014

    • Author(s)
      Oka M, Nozu K, Kaito H, Fu XJ, Nakanishi K, Hashimura Y, Morisada N, Yan K, Matsuo M, Yoshikawa N, Vorechovsky I, Iijima K
    • Journal Title

      Pediatr Nephrol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Rituximab treatment combined with methylprednisolone pulse therapy and immunosuppressants for childhood steroid-resistant nephrotic syndrome2014

    • Author(s)
      Kamei K, Okada M, Sato M, Fujimaru T, Ogura M, Nakayama M, Kaito H, Iijima K, Ito S
    • Journal Title

      Pediatr Nephrol

      Volume: 29(7) Pages: 1181-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] The problem of transition from pediatric to adult healthcare in patients with steroid-sensitive nephrotic syndrome (SSNS): a survey of the experts2014

    • Author(s)
      Honda M, Iijima K, Ishikura K, Kaneko K
    • Journal Title

      Clin Exp Nephrol

      Volume: (Epub ahead of print)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Milder clinical aspects of X-linked Alport syndrome in men positive for the collagen IVα5 chain2014

    • Author(s)
      Hashimura Y, Nozu K, Kaito H, Nakanishi K, Fu XJ, Ohtsubo H, Hashimoto F, Oka M, Ninchoji T, Ishimori S, Morisada N, Matsunoshita N, Kamiyoshi N, Yoshikawa N, Iijima K
    • Journal Title

      Kidney Int.

      Volume: 85(5) Pages: 1208-13

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cyclosporine C2 monitoring for the treatment of frequently relapsing nephrotic syndrome in children : a multicenter randomized phase II trial2014

    • Author(s)
      Iijima K, Sako M, Oba MS, Ito S, Hataya H, Tanaka R, Ohwada Y, Kamei K, Ishikura K, Yata N, Nozu K, Honda M, Nakamura H, Nagata M, Ohashi Y, Nakanishi K, Yoshikawa N; Japanese Study Group of Kidney Disease in Children
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 9(2) Pages: 271-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Acute kidney injury after acute gastroenteritis in an infant with hereditary hypouricemia2014

    • Author(s)
      Kamei K, Ogura M, Ishimori S, Kaito H, Iijima K, Ito S
    • Journal Title

      Eur JPediatr

      Volume: 173(2) Pages: 247-913

    • Related Report
      2013 Final Research Report
  • [Journal Article] Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans2014

    • Author(s)
      Hara S, Umeyama K, Yokoo T, Nagashima H, Nagata M
    • Journal Title

      PLoS One

      Volume: 9(3)

    • NAID

      120007130512

    • Related Report
      2013 Final Research Report
  • [Journal Article] Cyclosporine C2 Monitoring for the Treatment of Frequently Relapsing Nephrotic Syndrome in Children: A Multicenter Randomized Phase II Trial.2014

    • Author(s)
      Iijima K, Sako M, Oba MS, Ito S, Hataya H, Tanaka R, Ohwada Y, Kamei K, Ishikura K, Yata N, Nozu K, Honda M, Nakamura H, Nagata M, Ohashi Y, Nakanishi K, Yoshikawa N. : Japanese Study Group of Kidney Disease in Children.
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 9(2) Issue: 2 Pages: 271-8

    • DOI

      10.2215/cjn.13071212

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular background of urate transporter genes in patients with exercise-induced acute kidney injury2013

    • Author(s)
      Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K
    • Journal Title

      Am J Nephrol

      Volume: 38(4) Pages: 316-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] SLC26A3 gene analysis in patients with Bartter and Gitelman syndromes and the clinical characteristics of patients with unidentified mutations2013

    • Author(s)
      Ishimori S, Kaito H, Matsunoshita N, Otsubo H, Hashimoto F, Ninchoji T, Nozu K, Morisada N, Iijima K
    • Journal Title

      Kobe J Med Sci.

      Volume: 59(2)

    • NAID

      110009595389

    • Related Report
      2013 Final Research Report
  • [Journal Article] Different phenotypes of HNF1ß deletion mutants in familial multicystic dysplastic kidneys2013

    • Author(s)
      Hasui M, Kaneko K, Tsuji S, Isozaki Y, Kimata T, Nozu Y, Nozu K, Iijima K
    • Journal Title

      Clin Nephrol

      Volume: 79(6)(PubMed PMID : 23725647) Pages: 484-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] First Japanese case of Pierson syndrome with mutations in LAMB22013

    • Author(s)
      Togawa H, Nakanishi K, Mukaiyama H, Hama T, Shima Y, Nakano M, Fujita N, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Int.

      Volume: 55(2) Pages: 229-31

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reference ranges for serum cystatin C measurements in Japanese children by using 4 automated assays2013

    • Author(s)
      Yata N, Uemura O, Honda M, Matsuyama T, Ishikura K, Hataya H, Nagai T, Ikezumi Y, Fujita N, Ito S, Iijima K, Saito M, Keneko T, Kitagawa T
    • Journal Title

      Clin Exp Nephrol

      Volume: 17(6) Pages: 872-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic nephrotic syndrome2013

    • Author(s)
      Nakanishi K, Iijima K, Ishikura K, Hataya H, Nakazato H, Sasaki S, Honda M, Yoshikawa N; Japanese Study Group of Renal Disease in Children
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 8(5) Pages: 756-62

    • Related Report
      2013 Final Research Report
  • [Journal Article] Endoplasmic reticulum stress with low-dose cyclosporine in frequently relapsing nephrotic syndrome2013

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Shima Y, Togawa H, Sako M, Nozu K, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 28(6) Pages: 903-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis2013

    • Author(s)
      Hamasaki Y, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ishikura K, Ito S, Kaneko T, Honda M; for Japanese Study Group of Renal Disease in Children
    • Journal Title

      Pediatr Nephrol

      Volume: 28(5) Pages: 765-71

    • Related Report
      2013 Final Research Report
  • [Journal Article] Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome2013

    • Author(s)
      Ito S, Kamei K, Ogura M, Udagawa T, Fujinaga S, Saito M, Sako M, Iijima K
    • Journal Title

      Pediatr Nephrol

      Volume: 28(2) Pages: 257-64

    • Related Report
      2013 Final Research Report
  • [Journal Article] Spontaneous remission in children with IgA nephropathy2013

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Sako M, Kaito H, Nozu K, Tanaka R, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 28(1) Pages: 71-6

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Establishment of a normal reference value for serumβ2 microglobulin in Japanese children : reevaluation of its clinical usefulness2013

    • Author(s)
      Ikezumi Y, Honda M, Matsuyama T, Ishikura K, Hataya H, Yata N, Nagai T, Fujita N, Ito S, Iijima K, Kaneko T, Uemura O
    • Journal Title

      Clin Exp Nephrol

      Volume: 17(1) Pages: 99-105

    • NAID

      10031169450

    • Related Report
      2013 Final Research Report
  • [Journal Article] Aberrant Notch1-dependent effects on glomerular parietal epithelial cells promotes collapsing focal segmental glomerulosclerosis with progressive podocyte loss2013

    • Author(s)
      Ueno T, Kobayashi N, Nakayama M, Takashima Y, Uesugi N, Pastan D, Pippin J, Shankland S, Matsusaka Nagata M
    • Journal Title

      Kidney Int

      Volume: 83(6) Pages: 1065-75

    • Related Report
      2013 Final Research Report
  • [Journal Article] A Novel Case of Nephrotic Syndrome Caused by Immune-Mediated Acquired LCAT Deficiency2013

    • Author(s)
      Takahashi S, Hiromura K, Tsukida M, Ohishi Y, Hamatani H, Sakurai N, Sakairi T, Ikeuchi H, Kaneko Y, Maeshima A, Kuroiwa T, Yokoo H, Nagata M, Nojima Y
    • Journal Title

      J Am Soc Nephrol

      Volume: 24(8) Pages: 1305-12

    • Related Report
      2013 Final Research Report
  • [Journal Article] Henoch-Schönlein purpura nephritis in a patient with IgG4-related disease : a possible association2013

    • Author(s)
      Ito K, Yamada K, Mizushima I, Aizu M, Fujii H, Mizutomi K, Matsumura M, Hayashi K, Yamagishi M, Umehara H, Yamaguchi Y, Nagata M, Kawano M
    • Journal Title

      Clin Nephrol

      Volume: 79(3) Pages: 246-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] The direction and role of phenotypic transition between podocytes and parietal epithelial cells in focal segmental glomerulosclerosis2013

    • Author(s)
      Sakamoto K, Ueno T, Kobayashi N, Hara S, Takashima Y, Pastan I, Matsusaka T, Nagata M
    • Journal Title

      Am J Physiol Renal Physiol

    • Related Report
      2013 Final Research Report
  • [Journal Article] Molecular background of urate transporter geneMolecular background of urate transporter genes in patients with exercise-induced acute kidney injury.2013

    • Author(s)
      Kaito H, Ishimori Kaito H, Ishimori S, Nozu K, Shima Y, Nakanishi K, Yoshikawa N, Iijima K.
    • Journal Title

      Am J Nephrol.

      Volume: 38(4) Issue: 4 Pages: 629-629

    • DOI

      10.1159/000355430

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic nephrotic syndrome2013

    • Author(s)
      Koichi Nakanishi、Kazumoto Iijima、Kenji Ishikura、Satoshi Sasak、Masataka Honda、Norio Yosikawa
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: Vol.8 Issue: 5 Pages: 756-762

    • DOI

      10.2215/cjn.09010912

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome.2013

    • Author(s)
      Ito S, Kemei K, Ogura M, Udagawa T, Fujinaga S, Saito M, Sako M, Iijima K
    • Journal Title

      Pediatr Nephrol

      Volume: 28 Issue: 2 Pages: 257-64

    • DOI

      10.1007/s00467-012-2319-1

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two-year follow-up of a prospective clinical trial of cyclosporine for frequently relapsing nephrotic syndrome in children2012

    • Author(s)
      Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ito S, Yata N, Ando T, Honda M; Japanese Study Group of Renal Disease in Children
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 7(10) Pages: 1576-83

    • Related Report
      2013 Final Research Report
  • [Journal Article] Is the new Schwartz equation derived from serum creatinine and body length suitable for evaluation of renal function in Japanese children?2012

    • Author(s)
      Uemura O, Honda M, Matsuyama T, Ishikura K, Hataya H, Nagai T, Ikezumi Y, Fujita N, Ito S, Iijima K; Japanese Society for Pediatric Nephrology, the Committee of Measures for Pediatric CKD
    • Journal Title

      Eur J Pediatr

      Volume: 171(9) Pages: 1401-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] Focal segmental glomerulosclerosis in patients with complete deletion of one WT1 allele2012

    • Author(s)
      Iijima K, Someya T, Ito S, Nozu K, Nakanishi K, Matsuoka K, Ohashi H, Nagata M, Kamei K, Sasaki S
    • Journal Title

      Pediatrics

      Volume: 129(6)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Renal biopsy criterion in children with asymptomatic constant isolated proteinuria2012

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(8) Pages: 3186-90

    • Related Report
      2013 Final Research Report
  • [Journal Article] Validity of the Oxford classification of IgA nephropathy in children2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, Kaito H, Sako M, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol

      Volume: 27(5) Pages: 783-92

    • Related Report
      2013 Final Research Report
  • [Journal Article] Remission of proteinuria in renal amyloidosis secondary to rheumatoid arthritis2012

    • Author(s)
      Ueno T, Takeda Y, Nagata M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 27(2) Pages: 633-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] Histological heterogeneity of glomerular segmental lesions in focal segmental glomerulosclerosis2012

    • Author(s)
      Honda K, Taneda S, Yumura W Nitta K, Oda H, Nagata M
    • Journal Title

      Int Urol Nephrol

      Volume: 44(1) Pages: 183-96

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characteristic tubulointerstitial nephritis in IgG4-related disease2012

    • Author(s)
      Yamaguchi Y, Kanetsuna Y, Honda K, Kawano M, Yamanaka N, Nagata M
    • Journal Title

      Human Pathol

      Volume: 43(4) Pages: 536-549

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical and histological changes associated with corticosteroid therapy in IgG4-related tubulointerstitial nephritis2012

    • Author(s)
      Mizushima I, Yamada K, Fujii H, Inoue D, Umehara H, Yamagishi M, Yamaguchi Y, Nagata M, Matsumura M, Kawano M
    • Journal Title

      Mod Rheumatol

    • NAID

      10031127240

    • Related Report
      2013 Final Research Report
  • [Journal Article] Validity of the Oxford classification of IgA nephropathy in children.2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Hashimura Y, Kaito H, Sako M, Iijima K, Yoshikawa N
    • Journal Title

      Pediatr Nephrol.

      Volume: 27(5) Issue: 5 Pages: 783-92

    • DOI

      10.1007/s00467-011-2061-0

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Alport-like glomerular basement membrane changes with renal-coloboma syndrome.2012

    • Author(s)
      Ohtsubo H, Morisada N, Kaito H, Nagatani K, Nakanishi K, Iijima K.
    • Journal Title

      Pediatr Nephrol.

      Volume: 27(7) Issue: 7 Pages: 1189-92

    • DOI

      10.1007/s00467-012-2125-9

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Focal segmental glomerulosclerosis in patients with complete deletion of one WT1 allele.2012

    • Author(s)
      Iijima K, Someya T, Ito S, Nozu K, Nakanishi K, Matsuoka K, Ohashi H, Nagata M, Kamei K, Sasaki S
    • Journal Title

      Pediatrics

      Volume: 129 Issue: 6 Pages: e1621-e1625

    • DOI

      10.1542/peds.2011-1323

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolomics analysis of umbilical cord blood clarifies changes in saccharides associated with delivery method.2012

    • Author(s)
      Hashimoto F, Nishiumi S, Miyake O, Takeichi H, Chitose M, Ohtsubo H, Ishimori S, Ninchoji T, Hashimura Y, Kaito H, Morisada N, Morioka I, Fukuoka H, Yoshida M, Iijima K.
    • Journal Title

      Early Hum Dev

      Volume: 89(5) Issue: 5 Pages: 315-20

    • DOI

      10.1016/j.earlhumdev.2012.10.010

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Renal biopsy criterion in children with asymptomatic constant isolated proteinuria.2012

    • Author(s)
      Hama T, Nakanishi K, Shima Y, Mukaiyama H, Togawa H, Tanaka R, Hamahira K, Kaito H, Iijima K, Yoshikawa N
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 27(8) Issue: 8 Pages: 3186-90

    • DOI

      10.1093/ndt/gfr750

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] for the Japanese Study Group of Renal Disease in Children. Two-Year Follow-Up of a Prospective Clinical Trial of Cyclosporine for Frequently Relapsing Nephrotic Syndrome in Children.2012

    • Author(s)
      Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ito S, Yata N, Ando T, Honda M
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 7 Issue: 10 Pages: 1576-1583

    • DOI

      10.2215/cjn.00110112

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese Society for Pediatric Nephrology, the Committee of Measures for Pediatric CKD. Is the new Schwartz equation derived from serum creatinine and body length suitable for evaluation of renal function in Japanese children?2012

    • Author(s)
      Uemura O, Honda M, Matsuyama T, Ishikura K, Hataya H, Nagai T, Ikezumi Y, Fujita N, Ito S, Iijima K.
    • Journal Title

      Eur J Pediatr.

      Volume: 171(9) Pages: 1401-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of TSC2/PKD1 contiguous gene deletion syndrome2011

    • Author(s)
      Oyazato Y, Iijima K, Emi M, Sekine T, Kamei K, Takanashi J, Nakao H, Namai Y, Nozu K, Matsuo M
    • Journal Title

      Kobe J Med Sci.

      Volume: 57(1)

    • NAID

      110009587766

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome2011

    • Author(s)
      Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaizumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs HD, Miyawaki T
    • Journal Title

      Clin Immunol

      Volume: 141(1) Pages: 111-20

    • Related Report
      2013 Final Research Report
  • [Journal Article] A surviving case of papillorenal syndrome with the phenotype of Potter sequence2011

    • Author(s)
      Fujioka K, Morioka I, Nozu K, Nishimoto M, Amano M, Tagami M, Honda S, Yokoyama N, Yamada H, Iijima K, Matsuo M
    • Journal Title

      Pediatr Int.

      Volume: 53(3) Pages: 406-8

    • NAID

      10029558611

    • Related Report
      2013 Final Research Report
  • [Journal Article] Maintenance therapy with mycophenolate mofetil after rituximab in pediatric patients with steroid-dependent nephrotic syndrome2011

    • Author(s)
      Ito S, Kamei K, Ogura M, Sato M, Fujimaru T, Ishikawa T, Udagawa T, Iijima K
    • Journal Title

      Pediatr Nephrol

      Volume: 26(10) Pages: 1823-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] Recurrent EIARF and PRES with severe renal hypouricemia by compound heterozygous SLC2A9 mutation2011

    • Author(s)
      Shima Y, Nozu K, Nozu Y, Togawa H, Kaito H, Matsuo M, Iijima K, Nakanishi K, Yoshikawa N
    • Journal Title

      Pediatrics

      Volume: 127(6)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Age, gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children : a multicenter study2011

    • Author(s)
      Uemura O, Honda M, Matsuyama T, Ishikura K, Hataya H, Yata N, Nagai T, Ikezumi Y, Fujita N, Ito S, Iijima K, Kitagawa T
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(5) Pages: 694-9

    • NAID

      10030341017

    • Related Report
      2013 Final Research Report
  • [Journal Article] Long-term results of a randomized controlled trial in childhood IgA nephropathy2011

    • Author(s)
      Kamei K, Nakanishi K, Ito S, Saito M, Sako M, Ishikura K, Hataya H, Honda M, Iijima K, Yoshikawa N; Japanese Pediatric IgA Nephropathy Treatment Study Group
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 6(6) Pages: 1301-7

    • Related Report
      2013 Final Research Report
  • [Journal Article] Treatment strategies for Henoch-Schönlein purpura nephritis by histological and clinical severity2011

    • Author(s)
      Ninchoji T, Kaito H, Nozu K, Hashimura Y, Kanda K, Kamioka I, Shima Y, Hamahira K, Nakanishi K, Tanaka R, Yoshikawa N, Iijima K, Matsuo M
    • Journal Title

      Pediatr Nephrol

      Volume: 26(4) Pages: 563-9

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Focal segmental glomerulosclerosis as a complication of hepatitis B virus infection2011

    • Author(s)
      Sakai K, Morito N, Usui J, Hagiwara M, Hiwatashi A, Fukuda K, Nanmoku T, Toda T, Matsui N, Nagata M, Yamagata K
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(1) Pages: 371-3

    • Related Report
      2013 Final Research Report
  • [Journal Article] Morphological and functional analyses of two infants with obstructive renal dysplasia2011

    • Author(s)
      Miura K, Sekine T, Nishimura R, Kanamori Y, Yanagisawa A, Sakai K, Nagata M, Igarashi T
    • Journal Title

      Clin Exp Nephrol

      Volume: 15(4) Pages: 602-6

    • NAID

      10029572082

    • Related Report
      2013 Final Research Report
  • [Journal Article] A case of multicentric Castleman's disease with membranoproliferative glomerulonephritis type 3-like lesion2011

    • Author(s)
      Nagai K, Usui J, Noguchi K, Unai K, Hiwatashi A, Arakawa Y, Togashi A, Morito N, Saito C, Yoh K, Tsuruoka S, Kojima H, Aita K, Nagata M, Yamagata K
    • Journal Title

      Pathol Int.

      Volume: 61(11) Pages: 686-90

    • NAID

      10031185142

    • Related Report
      2013 Final Research Report
  • [Journal Article] Preoperative dialysis for liver transplantation in methylmalonic acidemia2011

    • Author(s)
      Kamei K, Ito S, Shigeta T, Sakamoto S, Fukuda A, Horikawa R, Saito O, Muguruma T, Nakagawa S, Iijima K, Kasahara M
    • Journal Title

      Ther Apher Dial

      Volume: 15 Issue: 5 Pages: 488-492

    • DOI

      10.1111/j.1744-9987.2011.00974.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The relationship between arginine vasopressin levels and hyponatremia following a percutaneous renal biopsy in children receiving hypotonic or isotonic intravenous fluids2011

    • Author(s)
      Kanda K, Nozu K, Kaito H, Iijima K, Nakanishi K, Yoshikawa N, Ninchoji T, Hashimura Y, Matsuo M, Moritz ML
    • Journal Title

      Pediatr Nephrol

      Volume: 26 Issue: 1 Pages: 99-104

    • DOI

      10.1007/s00467-010-1647-2

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy2011

    • Author(s)
      Shima Y, Nakanishi K, Kamei K, Togawa H, Nozu K, Tanaka R, Sasaki S, Iijima K, Yoshikawa N
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Issue: 1 Pages: 163-169

    • DOI

      10.1093/ndt/gfq387

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent Deep Intronic Mutations in the SLC12A3 Gene Responsible for Gitelman's Syndrome2011

    • Author(s)
      Lo YF, Nozu K, Iijima K, Morishita T, Huang CC, Yang SS, Sytwu HK, Fang YW, Tseng MH, Lin SH
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 6 Issue: 3 Pages: 630-639

    • DOI

      10.2215/cjn.06730810

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epithelial-to-mesenchymal transition in cyst lining epithelial cells in an orthologous PCK rat model of autosomal-recessive polycystic kidney disease2011

    • Author(s)
      Togawa H, Nakanishi K, Mukaiyama H, Hama T, Shima Y, Sako M, Miyajima M, Nozu K, Nishii K, Nagao S, Takahashi H, Iijima K, Yoshikawa N
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 300 Issue: 2 Pages: F511-F520

    • DOI

      10.1152/ajprenal.00038.2010

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CAKUTに対する治療戦略 CAKUTと遺伝子変異2011

    • Author(s)
      飯島一誠
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 31 Pages: 9-10

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Heterozygous microdeletion of 16q covering SALL1 and RPGRIP1L could be a novel contiguous gene syndrome with renal impairment2013

    • Author(s)
      Morisada N, Taniguchi-Ikeda M, Ishimori S, Ninchoji T, Kaito H, Nozu K, Adach Mi, Takeshima Y, SekineT, Iijima K
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      Boston
    • Related Report
      2013 Final Research Report
  • [Presentation] Natural History and Protein Expression Pattern in Autosomal Recessive Alport Syndrome Based on the Comprehensive Strategy for Genetic Analysis2013

    • Author(s)
      Kaito H, Nozu K, Oka M, Morisada N, Ninchoji T, Nakanishi K, Yoshikawa N, Iijima K
    • Organizer
      American Society of Nephrology KIDNEY WEEK
    • Place of Presentation
      Atlanta
    • Related Report
      2013 Final Research Report
  • [Presentation] 遺伝性腎疾患の最近の知見2013

    • Author(s)
      飯島一誠
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] CAKUTの分子遺伝学的アプローチ2013

    • Author(s)
      飯島一誠
    • Organizer
      第22回日本小児泌尿器科学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 総排泄腔遺残をともなった1q21.1欠失症候群の1女児例2013

    • Author(s)
      森貞直哉,野田俊輔,降?めぐみ,池田真理子,竹島泰弘,飯島一誠
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetical and Clinical Aspects of X-Linked Alport Syndrome in Males with Positive Staining of the alpha5(IV) Chain2012

    • Author(s)
      Hashimura Y, Nozu K, Kaito H, Ohtsubo H, Hashimoto F, Ishimori S, Ninchoji T, Morisada N, Nakanishi K, Yoshikawa N, Iijima K
    • Organizer
      45th Annual Meeting of the American Society of Nephrology
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Genetic approaches in pediatric nephrology.2012

    • Author(s)
      Iijima K
    • Organizer
      Japan-Korea The 10th Pediatric Nephrology Seminar 2012
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Hyponatremic Hypertensive Syndrome in an Infant Child Presenting as Nephrotic Syndrome:2012

    • Author(s)
      Ninchoji T, Kaito H, Otsubo H, Hashimoto F, Ishimori S, Hashimura Y, Morisada N, Kawasaki A, Yamaguchi M, Iijima K.
    • Organizer
      Japan-Korea The 10th Pediatric Nephrology Seminar 2012
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Clinicopathological characteristics and kidney outcome of childhood-onset lupus nephritis with acute kidney injury: from the multicenter study in Japan.2012

    • Author(s)
      Ishimori S, Kaito H, Otsubo H, Hashimoto F, Ninchoji T, Hashimura Y, Kamioka I, Shima Y, Hamahira K, Nakanishi K, Tanaka R, Yoshikawa N, Iijima K.
    • Organizer
      45th Annual Scientific Meeting of the European Society for Pediatric Nephrology Krakow 2012.9.6-8
    • Place of Presentation
      Krakow
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical characteristics and mutational pattern of genetically-proven Gitelman’s syndrome.2012

    • Author(s)
      Ninchoji T, Kaito H, Nozu K, Nakanishi K, Yoshikawa N, Iijima K
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Genetical and clinical aspects of X-linked Alport syndrome in males with positive staining of the α5 (IV) chain.2012

    • Author(s)
      Hashimura Y, Nozu K, Kaito H, Ishimori S, Otsubo H, Hashimoto F, Ninchoji T, Morisada N, Nakanishi K, Yoshikawa N, Iijima K.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Histological Predictors of Treatment Efficacy in Severe Childhood IgA Nephropathy (IgAN): Validation of the Oxford Classification of IgAN (Ox C)2012

    • Author(s)
      Shima Y, Nakanishi K, Hama T, Mukaiyama H, Togawa H, Ishimori S, Kaito H, Tanaka R, Iijima K, Yoshikawa N.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Multicenter double-blind, randomized, placebo-controlled trial of rituximab for the treatment of childhood-onset refractory nephrotic syndrome.2012

    • Author(s)
      Iijima K, Sako M, Tuchida N, Ohashi Y.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] A novel UMOD mutation in a family with medullary cystic kidney disease type 2.2012

    • Author(s)
      Kamijo M, Tamura M, Ishimatsu N, Miyamoto T, Serino R, Kabashima N, Kanegae K, Furuno Y, Bando K, Nakamata J, Kuma A, Ishimori S, Morisada N, Iijima K, Otsuji Y.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Possible contribution of fibrocytes to renal fibrosis in Cpk mouse, a model of ARPKD.2012

    • Author(s)
      Hama T, Nakanishi K, Mukaiyama H, Togawa H, Shima Y, Miyajima M, Takahashi H, Nagao S, Iijima K, Yoshikawa N.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Mutation analysis in Japanese patients with congenital and infantile nephrotic syndrome.2012

    • Author(s)
      Mukaiyama H, Nakanishi K, Hama T, Togawa H, Shima Y, Iijima K, Yoshikawa N.
    • Organizer
      American Society of Nephrology, 2012 Kidney Week
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] リツキシマブ ネフローゼ症候群への応用2012

    • Author(s)
      飯島一誠,佐古まゆみ
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児頻回再発型ネフローゼ症候群に対するC2投与量調節法の他施設ランダム化比較(JSKDC03)2012

    • Author(s)
      佐古まゆみ,飯島一誠,斉藤真梨,大橋靖雄,吉川徳茂
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 日本人先天性ネフローゼ症候群における原因遺伝子検索2012

    • Author(s)
      向山弘展,中西浩一,戸川寛子,浜 武継,島 友子,飯島一誠,吉川徳茂
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 小児特発性ネフローゼ症候群におけるステロイド反応性と蛍光免疫染色所見との関連2012

    • Author(s)
      忍頂寺毅史,貝藤裕史,大坪裕美,橋本総子,石森真吾,森貞直哉,吉川徳茂,飯島一誠
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Alport syndrome associated with hemophilia A-molecular mechanism of phenotypic divergence between siblings.2011

    • Author(s)
      Hashimura Y, Nozu K, Otsubo H, Hashimoto S, Ishimori S, Morisada N, Kaito H,
    • Organizer
      Pediatric Academic Societies' 2011Annual Meeting
    • Place of Presentation
      Denver
    • Related Report
      2011 Research-status Report
  • [Presentation] Recurrent exercise-induced acute renal failure and PRES with severe renal hypouricemia by2011

    • Author(s)
      Shima Y, Nozu K, Togawa H, Kaito H, Iijima K, Matsuo M, Nakanishi K, Yoshikawa N.
    • Organizer
      Pediatric Academic Societies' 2011Annual Meeting
    • Place of Presentation
      Denver
    • Related Report
      2011 Research-status Report
  • [Presentation] "Alport-like"glomerular basement membrane changes in a Japanese girl with renal-coloboma syndrome due to PAX2 mutation.2011

    • Author(s)
      Otsubo H, Hashimoto S, Ishimori S, Hashimura Y, Fu XJ, Kaito H, Morisada N, Nagatani K, Iijima K, Matsuo M.
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Research-status Report
  • [Presentation] Deep intronic mutations in COL4A5 causes X-linked Alport syndrome.2011

    • Author(s)
      Hashimoto F, Nozu K, Otsubo H, Ishimori S, Hashimura Y, Kaito H, Nakanishi K,
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical characteristics of silent lupus nephritis in children: a single center experience.2011

    • Author(s)
      Ishimori S, Otsubo H, Hashimoto F, Hashimura Y, Kaito H, Morisada N, Yoshikawa N,
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical distinction between genetically-proven gitelman's and pseudo-gitelman's syndrome2011

    • Author(s)
      Ninchoji T,Kaito H, Nozu K,Hashimura Y,Nakanishi K, Yoshikawa N,Iijima K,Matsuo M
    • Organizer
      ERA-EDTA Congress
    • Place of Presentation
      Praha
    • Related Report
      2011 Research-status Report
  • [Presentation] Investigation of molecular background for patients with exercise-idcuced acute renal failure.2011

    • Author(s)
      Kaito H, Nozu K,Nakanishi K, Hashimura Y,Shima Y,Ninchoji T,Yoshikawa N,Iijima K,Matsuo M.
    • Organizer
      ERA-EDTA Congress
    • Place of Presentation
      Praha
    • Related Report
      2011 Research-status Report
  • [Presentation] Genetic Backgrounds in Patients with Glomerulopathy with Fibronectin2011

    • Author(s)
      Ohtsubo H,Hashimoto F,Ishimori S,Ninchoji T,Fu XueJun,Hashimura Y,Kaito H,Morisada N,Uesugi N,Iijima K.
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      Philadelphia
    • Related Report
      2011 Research-status Report
  • [Presentation] Cyclosporine C2 monitoring for frequent-relapsing nephrotic syndrome in children: A multicenter randomized controlled trial2011

    • Author(s)
      Iijima K, Sako Nakamura M, Saito M, Ohashi Y, Yoshikawa N
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      Philadelphia
    • Related Report
      2011 Research-status Report
  • [Presentation] Rituximab for refractory nephrotic syndrome2011

    • Author(s)
      Iijima K
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology(招待講演)
    • Place of Presentation
      Fukuoka
    • Related Report
      2011 Research-status Report
  • [Presentation] 小児難治性ネフローゼ症候群の新たな治療戦略2011

    • Author(s)
      飯島一誠
    • Organizer
      第41回日本腎臓学会西部学術大会(招待講演)
    • Place of Presentation
      徳島
    • Related Report
      2011 Research-status Report
  • [Book] 先天代謝異常ハンドブック2013

    • Author(s)
      飯島一誠
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report
  • [Book] 腎低形成・異形成.小児腎臓病学,日本小児腎臓病学会編(編集主幹飯島一誠他)2012

    • Author(s)
      長田道夫
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療指針 2012年版2012

    • Author(s)
      飯島一誠
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 最新ガイドライン準処 小児科診断・治療指針2012

    • Author(s)
      飯島一誠
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report
  • [Book] 小児腎臓病学2012

    • Author(s)
      飯島一誠
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 特発性ネフローゼ症候群 小児腎臓病学2012

    • Author(s)
      飯島一誠
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report
  • [Book] 微小変化型ネフローゼ症候群:小児 2011-2013 腎疾患・透析 最新の治療2011

    • Author(s)
      飯島一誠
    • Publisher
      南江堂
    • Related Report
      2011 Research-status Report
  • [Book] 小児ステロイド抵抗性ネフローゼ症候群に対するリツキシマブの効果は? 2011-2012 EBM小児疾患の治療2011

    • Author(s)
      飯島一誠,貝藤裕史,伊藤秀一
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report
  • [Book] 小児ネフローゼ症候群の新たな治療 Annual Review腎臓20112011

    • Author(s)
      飯島一誠,佐古まゆみ
    • Publisher
      中外医学社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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