Analysis of DNA repair, cell cycle progression and cell death in dedifferentiation and regeration of renal tubular cells

Research Project

Project/Area Number	23591194
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Kidney internal medicine
Research Institution	Kochi University
Principal Investigator	HIRANO SEIKI 高知大学, 教育研究部医療学系, 助教 (20368616)
Co-Investigator(Kenkyū-buntansha)	TERADA Yoshio 高知大学, 教育研究部医療学系, 教授 (30251531)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	腎尿細管障害 / 急性腎障害 / 細胞周期 / DNA修復 / 尿細管再生
Research Abstract	The number of hemodialysis patient is increasing, which is a critical problem in Japan. To analyze repair and regeneration of renal tubular cells after renal failure will contribute the way of preventive therapy of renal disease. I found that renal tubular cells express the markers of de-differentiation after cell damage and they form tubule when the marker is expressed. I am trying to do further analyses.

Report

(4 results)