A role of NETs for damage of renal glomerular endothelial cells in ANCA-associated renal vasculitis
| Project/Area Number |
23591199
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMURA Yoshihiro 杏林大学, 医学部, 教授 (40222765)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腎臓学 / ANCA関連血管炎 / 好中球 / 糸球体腎炎 |
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| Research Abstract |
Pathological examination of renal biopsies from ANCA-associated vasculitis indicated that there was a glomerular infiltration of MPO-positive cells along with deposition of extracellular. Chromatin fibers called NETs are released from neutrophils. It has been known that NETs are implicated in the pathogenesis of ANCA-associated vasculitis (AAV). We observed NETs formation in order to investigate the role of NETs in AAV.
Peripheral blood neutrophils from AAV patients were primed with phorbolmyristate acetate(PMA) and the percentage of NETs producing cells were calculated. Neutrophils from active AAV patients produced much more fiber-like NETs than neutrophils from controls. The release of fiber-like NETs was markedly decreased by treatment for AAV. These data suggest the release of NETs by neutrophil at vascular endothelium is important for the pathogenesis of AAV.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study2012
Author(s)
Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y, Kurokawa MS, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W, Amano K, Arimura Y, Hatta K, Ito S, Kikuchi H, Muso E, Nakashima H, Ohsone Y, Suzuki Y, Hashimoto H, Koyama A, Matsuo S, Kato H
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Journal Title
Mod Rheumatol
Volume: 22(3)
Pages: 394-404
Related Report
Peer Reviewed
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[Presentation] A case of lung biopsy-proven MPO-ANCA positive granulomatosis with polyangiitis2013
Author(s)
Murakami K, Saito M, Komagata Y, Yoshihara K, Kaname S, Arimura Y, Yamada A, Nakamoto Y, Ishida M, Hikgaki M, Takizawa H, Kawauchi R, Goya T, Fujiwara M, Yazawa T, Kamma H
Organizer
16th International Vasculitis & ANCA Workshop
Place of Presentation
France
Related Report
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