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Tlanslating podocyte biology into new therapys and examinations for podocyte injury

Research Project

Project/Area Number 23591201
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKyoto University (2013)
Juntendo University (2011-2012)

Principal Investigator

ASANUMA KATSUHIKO  京都大学, 医学(系)研究科(研究院), 准教授 (60449064)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsポドサイト / 腎障害 / ネフローゼ症候群 / スリット膜 / アポトーシス / 慢性腎臓病 / Notch2 / dendrin / YAP2 / 活性型ビタミンD
Research Abstract

Glomerular visceral epithelial cells, also known as podocytes, serve as the final barrier to urinary protein loss. Podocyte injury may cause podocyte detachment, which leads to glomerulosclerosis. In our established model mice, severe podocyte injury induced podocyte loss and apoptosis, and glomeruloscrelosis. Using the mice model, we reported that treatment of 220oxa-calcitriol and Nothc2 agonist antibody suppressed podocyte loss and apoptosis. Furthermore, we reported that the measurement of urinary podocalyxin may be a useful biomarker to determine activity of IgA nephropathy and the effectiveness of corticosteroid treatment to IgA nephropathy.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (73 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 13 results,  Open Access: 2 results) Presentation (35 results) (of which Invited: 6 results) Book (10 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy2014

    • Author(s)
      Trejo JAO, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 446 Pages: 1190-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Notch2 activation ameliorates nephrosis.2014

    • Author(s)
      Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y.
    • Journal Title

      Nature communications

      Volume: 5 Issue: 1 Pages: 3296-3296

    • DOI

      10.1038/ncomms4296

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.2014

    • Author(s)
      Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
    • Journal Title

      Biochemical and biophysical research communications

      Volume: 446(4) Issue: 4 Pages: 1190-1196

    • DOI

      10.1016/j.bbrc.2014.03.088

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New therapeutic insights for chronic kidney disease provided by podocytology2014

    • Author(s)
      Inoue R, Asanuma K, Seki T, Nagase M, Osafune K.
    • Journal Title

      Nihon Yakurigaku Zasshi.

      Volume: 143 Pages: 27-33

    • NAID

      130004827686

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patoents with IgA nephropathy2013

    • Author(s)
      Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y
    • Journal Title

      Nephrol Dial Transplant

      Volume: 28(F K, K A contributed equally to this publication) Pages: 1762-72

    • Related Report
      2013 Final Research Report
  • [Journal Article] YAP promotes cell survival by inhibiting pro-apoptotic dendrin signaling2013

    • Author(s)
      Campbell KN, Wong JS, Gupta R, Asanuma K, Sudol M, He JC, Mundel P
    • Journal Title

      J Biol Chem

      Volume: 288 Pages: 17057-62

    • Related Report
      2013 Final Research Report
  • [Journal Article] Telmisartan inhibits AGE-induced podocyte damage and detachment2013

    • Author(s)
      Fukami K, Yamagishi SI, Kaifu K, Matsui T, Kaida Y, Ueda S, Takeuchi M, Asanuma K, Okuda S
    • Journal Title

      Microvasc Res

      Volume: 88 Pages: 79-83

    • Related Report
      2013 Final Research Report
  • [Journal Article] PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation2013

    • Author(s)
      Ishibashi Y, Matsui T, Ohta K, Tanoue R, Takeuchi M, Asanuma K, Fukami K, Okuda S, Nakamura KI, Yamagishi SI
    • Journal Title

      Microvasc Res

      Volume: 85 Pages: 54-8

    • Related Report
      2013 Final Research Report
  • [Journal Article] YAP promotes cell survival by inhibiting pro-apoptotic dendrin signaling.2013

    • Author(s)
      Campbell KN, Wong JS, Gupta R, Asanuma K, Sudol M, He JC, Mundel P.
    • Journal Title

      J Biol Chem.

      Volume: 288 Issue: 24 Pages: 17057-17062

    • DOI

      10.1074/jbc.c113.457390

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan inhibits AGE-induced podocyte damage and detachment.2013

    • Author(s)
      Fukami K, Yamagishi SI, Kaifu K, Matsui T, Kaida Y, Ueda S, Takeuchi M, Asanuma K, Okuda S.
    • Journal Title

      Microvasc Res.

      Volume: 88 Pages: 79-83

    • DOI

      10.1016/j.mvr.2013.04.006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk of overexpression of kidney function using GFR-estimating equations in patients with low insulin clearance2012

    • Author(s)
      Nakata J, Ohsawa I, Onda K, tanimoto M, Kusaba G, Takeda Y, Kobayashi N, Asanuma K, Tanaka Y, Sato M, Inami Y, Suzuki H, Suzuki H, Masuda A, Nonaka K, Sasaki Y, Hisada A, Hamada C, Horikoshi S, Tomino Y
    • Journal Title

      J clin Lab Anal

      Volume: 26 Pages: 248-253

    • Related Report
      2013 Final Research Report
  • [Journal Article] N-type calcium channel inhibition with Cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition2012

    • Author(s)
      Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A
    • Journal Title

      J Pharmacol Sci

      Volume: 119 Pages: 359-67

    • NAID

      10031071591

    • Related Report
      2013 Final Research Report
  • [Journal Article] Relationships between levels of urinary podocalyxin, number of urinary podocytes and histological injury in adult patients with IgA nephropathy2012

    • Author(s)
      Asao R, Asanuma K, Kodama F, Akiba-Takagi M, Hosoe-Nagai Y, Seki T, Takeda Y, Ohsawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horikoshi S, Hara M, Tomino Y
    • Journal Title

      Clin J Am Soc Nephrol

      Volume: 7(R A, K A contributed equally to this publication) Pages: 1385-93

    • Related Report
      2013 Final Research Report
  • [Journal Article] PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation.2012

    • Author(s)
      Ishibashi Y, Matsui T, Ohta K, Tanoue R, Takeuchi M, Asanuma K, Fukami K, Okuda S, Nakamura KI, Yamagishi SI.
    • Journal Title

      Microvasc Res.

      Volume: 85 Pages: 54-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patoents with IgA nephropathy.2012

    • Author(s)
      Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 28 Pages: 1762-72

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-type calcium channel inhibition with Cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition.2012

    • Author(s)
      Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A
    • Journal Title

      J Pharmacol Sci.

      Volume: 119 Pages: 359-67

    • NAID

      10031071591

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyaline vascular type of unicentric Castleman's disease with proliferation of glomerular endothelial cells.2012

    • Author(s)
      Wakabayashi K, Asanuma K, Takeda Y, Arakawa A, Osawa I, Horikoshi S, Yao T, Tomino Y.
    • Journal Title

      Clin Nephrol

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis2011

    • Author(s)
      Lydia A, Asanuma K, Nonaka K, Takagi M, Jeong K-H, Kodama F, Asao R, Asanuma E, Prodjosudjadi W, Tomino Y
    • Journal Title

      Am J Nephrol

      Volume: 35(A L, K A contributed equally to this publication) Pages: 58-68

    • Related Report
      2013 Final Research Report
  • [Journal Article] Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice2011

    • Author(s)
      Takagi-Akiba M, Asanuma K, Tanida I, Tada N, Trejo JAO, Nonaka K, Asanuma E, Eiki Kominami E, Ueno T, Tomino Y
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 302

    • Related Report
      2013 Final Research Report
  • [Journal Article] mTORC1 activation triggers the unfold protein response in podocytes and leads to nephritic syndrome2011

    • Author(s)
      Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, Asanuma K, Sai Y, Miyamoto KI, Takenaka H, Yan K
    • Journal Title

      Lab Invest

      Volume: 91 Pages: 1584-1595

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dendrin location in podocytes is associated with the disease progression in animal and human glomerulopathy2011

    • Author(s)
      Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A, Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanuma E, Kominami E, Ueno T, Tomino Y
    • Journal Title

      Am J Nephrol

      Volume: 23 Pages: 537-549

    • Related Report
      2013 Final Research Report
  • [Journal Article] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis.2011

    • Author(s)
      Lydia A, et al.
    • Journal Title

      Am J Nephrol.

      Volume: 35 Pages: 58-68

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Doxorubicin-induced glomerulosclerosis with proteinuria in GFP-GABARAP transgenic mice.2011

    • Author(s)
      Takagi-Akiba M, et al.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 302

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] mTORC1 activation triggers the unfold protein response in podocytes and leads to nephritic syndrome.2011

    • Author(s)
      Ito N, et al.
    • Journal Title

      Lab Invest.

      Volume: 91 Pages: 1584-1595

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dendrin location in podocytes is associated with the disease progression in animal and human glomerulopathy.2011

    • Author(s)
      Asanuma K, et al.
    • Journal Title

      Am J Nephrol.

      Volume: 23 Pages: 537-549

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] One-year results of an open-label study on antiproteinuric effect of benidipine in elderly patients with chronic kidney disease.2011

    • Author(s)
      Tomino Y, et al.
    • Journal Title

      J Nephrol.

      Volume: 24 Pages: 756-763

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ポドサイト障害時におけるRac1の役割について2014

    • Author(s)
      淺沼克彦、浅尾りん、関卓人、富野康日己
    • Organizer
      第9回弥彦ポドサイトセミナー
    • Place of Presentation
      コープシティー花園ガレッソホール、新潟
    • Year and Date
      2014-03-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 血液透析患者における大動脈弓部石灰化とその増悪因子の検討2013

    • Author(s)
      木原正夫、鈴木仁、淺沼克彦、堀越哲、富野康日己
    • Organizer
      第58回日本透析医学会学術集会・総会
    • Place of Presentation
      福岡国際会議場、博多
    • Year and Date
      2013-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎臓の発生に必須な蛋白質であるSall1のポドサイト障害からの回復期における保護的役割2013

    • Author(s)
      細江佳子、淺沼克彦、上野隆、西中村隆一、富野康日己
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2013-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Notch2アゴニスト抗体による糸球体硬化改善効果の検討2013

    • Author(s)
      田中絵里子、淺沼克彦、佐々木有、関卓人、Oliva Trejo Juan Alejandro、野中香苗、浅尾りん、細江佳子、日高輝夫、水谷修紀、八木田秀雄、富野康日己
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2013-05-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎臓の発生に必須なSall1蛋白の糸球体足細胞(ポドサイト)における役割2012

    • Author(s)
      細江佳子、淺沼克彦、西中村隆一、富野康日己
    • Organizer
      第3回分子腎臓フォーラム
    • Place of Presentation
      ベルサール八重洲、東京
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] ポドサイト障害におけるNotch2 pathway再活性化は糸球体硬化を抑制する2012

    • Author(s)
      田中絵里子、淺沼克彦、関卓人、野中香苗、浅尾りん、細江佳子、高木美幸、水谷修紀、八木田秀雄、富野康日己
    • Organizer
      第47回小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis2012

    • Author(s)
      Lidia Aida、淺沼克彦、野中香苗、高木美幸、富野康日己
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ポドサイト障害におけるNotch再活性化とreceptor特異的糸球体硬化抑制機能の検討2012

    • Author(s)
      田中絵里子、淺沼克彦、関卓人、野中香苗、浅尾りん、細江佳子、高木美幸、水谷修紀、八木田秀雄、富野康日己
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-01
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of Sall1, indispensable protein for kidney development, in podocytes under physiological and pathological conditions2012

    • Author(s)
      Yoshiko Nagai-Hosoe, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Eriko Tanaka, Lawrence B. Holzman, Ryuichi Nisahinakamura and Yasuhiko Tomino
    • Organizer
      9^<th> Inter national Podocyte Conference
    • Place of Presentation
      Miami
    • Year and Date
      2012-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Relationship between Urinary Podocalyxin Level and Histological Activity in Patients with IgA Nephropathy2012

    • Author(s)
      Rin Asao, Katsuhiko Asanuma, Fumiko Kodama, Miyuki Akiba-Takagi, Yoshiko Nagai-Hosoe, Takuto Seki, Yukihiko Takeda, Isao Ohsawa, Satoshi Mano, Kiyoshi Matsuoka, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama, Satoshi, Sakari Sekine, Satoshi Horikoshi, Masanori Hara, Yasuhiko Tomino
    • Organizer
      The 9^<th> inter national podocyte conference
    • Place of Presentation
      Miami
    • Year and Date
      2012-04-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Notch2 pathway reactivation ameliorates urinary protein and glomerular sclerosis in adriamycin nephropathy mice2012

    • Author(s)
      Eriko Tanaka, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Yoshiko Hosoe, Miyuki Takagi, Alejandro Oliva, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino
    • Organizer
      9th International Podocyte Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] Overexpression of GFP-GABARAP causes deterioration of proteinuria and glomeruloscrelosis in adriamycin-induced nephropathy mice2011

    • Author(s)
      Katsuhiko Asanuma, Miyuki Takagi, Kanae Nonaka, Etsuko Asanuma, Takashi Ueno, Yasuhiko Timino
    • Organizer
      ASN Annual Meeting
    • Place of Presentation
      Philadelphia
    • Year and Date
      2011-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] ネフローゼ症候群・糸球体硬化モデルとヒト糸球体疾患におけるスリット膜関連蛋白―デンドリンの核移行と糸球体病変との関連性2011

    • Author(s)
      高木美幸、淺沼克彦、児玉史子、浅尾りん、永井佳子、福田裕光、田中絵里子、淺沼悦子、木南英紀、上野隆、富野康日己
    • Organizer
      第12回東京腎炎・ネフローゼ研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of Cyclosporine on podocytes2011

    • Author(s)
      Asannuma K
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology(招待講演)
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 糸球体上皮細胞におけるNotch経路再活性化の阻害についての検討2010

    • Author(s)
      田中絵里子、淺沼克彦、高木美幸、児玉史子、浅尾りん、福田裕光、八木田秀雄、川崎明美、水谷修紀、富野康日己
    • Organizer
      第45回日本小児腎臓病学会学術集
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] ポドサイト障害時におけるRac1の役割について.

    • Author(s)
      淺沼克彦、浅尾りん、関卓人、富野康日己.
    • Organizer
      第9回弥彦ポドサイトセミナー
    • Place of Presentation
      コープシティー花園ガレッソホール、新潟
    • Related Report
      2013 Annual Research Report
  • [Presentation] Notch2アゴニスト抗体による糸球体硬化改善効果の検討.

    • Author(s)
      田中絵里子、淺沼克彦、佐々木有、関卓人、Oliva Trejo Juan Alejandro、野中香苗、浅尾りん、細江佳子、日高輝夫、水谷修紀、八木田秀雄、富野康日己.
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎臓の発生に必須な蛋白質であるSall1のポドサイト障害からの回復期における保護的役割.

    • Author(s)
      細江佳子、淺沼克彦、上野隆、西中村隆一、富野康日己.
    • Organizer
      第56回日本腎臓学会学術総会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポドサイト障害におけるNotch2 pathway再活性化は糸球体硬化を抑制する.

    • Author(s)
      田中絵里子、淺沼克彦、関卓人、野中香苗、浅尾りん、細江佳子、高木美幸、水谷修紀、八木田秀雄、富野康日己.
    • Organizer
      第47回小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis.

    • Author(s)
      Lydia Aida、 淺沼克彦、野中香苗、高木美幸、富野康日己.
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ポドサイト障害におけるNotch再活性化とreceptor特異的糸球体硬化抑制機能の検討.

    • Author(s)
      田中絵里子、淺沼克彦、関卓人、野中香苗、浅尾りん、細江佳子、高木美幸、水谷修紀、八木田秀雄、富野康日己
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Notch2 pathway reactivation ameliorates urinary protein and glomerular sclerosis in adriamycin nephropathy mice.

    • Author(s)
      Eriko Tanaka, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Yoshiko Hosoe, Miyuki Takagi, Alejandro Oliva, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino.
    • Organizer
      9th International Podocyte Conference.
    • Place of Presentation
      Maiami
    • Related Report
      2012 Research-status Report
  • [Presentation] The role of Sall1, indispensable protein for kidney development, in podocytes under physiological and pathological conditions.

    • Author(s)
      Yoshiko Nagai-Hosoe, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Eriko Tanaka, Lawrence B. Holzman, Ryuichi Nisahinakamura and Yasuhiko Tomino
    • Organizer
      9th International Podocyte Conference.
    • Place of Presentation
      Maiami
    • Related Report
      2012 Research-status Report
  • [Presentation] Relationship between Urinary Podocalyxin Level and Histological Activity in Patients with IgA Nephropathy.

    • Author(s)
      Rin Asao, Katsuhiko Asanuma, Fumiko Kodama, et.al.
    • Organizer
      9th International Podocyte Conference.
    • Place of Presentation
      Maiami
    • Related Report
      2012 Research-status Report
  • [Presentation] The structure and function of kidney podocytes

    • Author(s)
      淺沼克彦
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ポドサイト障害に対する検査と創薬の試み

    • Author(s)
      淺沼克彦
    • Organizer
      第8回腎と免疫くずりゅうセミナー研究会
    • Place of Presentation
      福井
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 腎障害におけるポドサイトの役割

    • Author(s)
      淺沼克彦
    • Organizer
      Renal Transplantation Forum 2012
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 話し合う腎臓:ネフロンセグメント間あるいは周辺細胞とのクロストーク「ポドサイトと糸球体構成細胞のクロストーク」

    • Author(s)
      淺沼克彦
    • Organizer
      第55回日本腎臓学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 「糖尿病腎症の成因 up date」 「糖尿病腎症進展における糸球体足細胞(ポドサイト)の役割」

    • Author(s)
      淺沼克彦
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy

    • Author(s)
      Katsuhiko Asanuma
    • Organizer
      9th International Podocyte Conference.
    • Place of Presentation
      Miami
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ネフローゼ症候群・糸球体硬化モデルとヒト糸球体疾患におけるスリット膜関連蛋白―デンドリンの核移行と糸球体病変との関連性.

    • Author(s)
      高木美幸、他
    • Organizer
      第12回東京腎炎・ネフローゼ研究会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] ポドサイト障害メカニズムの分子生物学的検討

    • Author(s)
      淺沼克彦
    • Organizer
      第54回日本腎臓学会学術集会(招待講演)
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] FSGSを上皮細胞のバイオロジーから考える、糸球体硬化におけるポドサイト喪失とそのメカニズム

    • Author(s)
      淺沼克彦
    • Organizer
      第54回日本腎臓学会学術集会(招待講演)
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 「FSGSの病態と治療」ポドサイト障害と糸球体硬化の発症・進展機序

    • Author(s)
      淺沼克彦
    • Organizer
      第12回東京腎炎ネフローゼ研究会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 新規スリット膜蛋白・dendrinのポドサイト障害における役割

    • Author(s)
      淺沼克彦
    • Organizer
      第39回新潟腎カンファレンス (招待講演)
    • Place of Presentation
      新潟
    • Related Report
      2011 Research-status Report
  • [Book] Annual Review腎臓(共著者)D.検査診断ポドサイト障害の評価法2014

    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] わかりやすい内科学(第4版)(共著者)第10章腎・尿路疾患、水・電解質異常、5.原発性糸球体疾患、III慢性糸球体腎炎、a.慢性糸球体腎炎、b. IgA腎症2014

    • Publisher
      文光堂
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review腎臓、(共著者)III. Clinical nephropathy, A糸球体障害, 2.足細胞障害とオートファジー2013

    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 臨床医学の基礎放射線診療を支える人のために(共著者)6腎泌尿器2013

    • Publisher
      PILAR PRESS
    • Related Report
      2013 Final Research Report
  • [Book] はじめての根拠がわかる看護実践禁忌なび(共著者)肝・腎・皮膚まどの生検後は、患者さんのバイタルサインの確認を怠ってはならない。脊髄造影後に安静をとる患者さんの頭位は、低くしてはならない。2013

    • Publisher
      株式会社南江堂
    • Related Report
      2013 Final Research Report
  • [Book] 「CKDの診療テキスト」(共著者)、B.腎臓専門医の診療、1.腎機能・尿検査、①尿蛋白のselectivity index(選択指数)とは何ですか?, ⑨難治性ネフローゼ症候群とはどういう疾患ですか?2013

    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] ここが知りたい生活習慣病・腎臓病・高血圧対策Q&A100(共著者)Q34血液中の尿酸値が高いと言われましたが、そのままでいるとどうなるでしょうか?, Q35腎臓の機能評価に血清クレアチニン値が使われていますが、どういうことでしょうか?2012

    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] ビジュアル糖尿病腎症のすべて(共著者) 腎症の病因と病態生理:ポドサイト障害2012

    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] 透析ナーシングQ&A(共著者)Q44透析患者の降圧目標はどのくらいですか?, Q69透析中に携帯電話を使用しても問題はありませんか?2012

    • Publisher
      総合医学社
    • Related Report
      2013 Final Research Report
  • [Book] 臨床病理レビュー特集号、若手医師と臨床検査技師のための尿検査・腎機能検査の実際と臨床的意義、第2章各論I.尿検査尿検査の実際と臨床的意義、12)ポドカリキシン定量

    • Related Report
      2013 Final Research Report
  • [Remarks] TMKプロジェクト

    • URL

      http://www.tmk.med.kyoto-u.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎疾患治療薬2012

    • Inventor(s)
      田中絵里子、八木田秀雄、淺沼克彦、 富野康日己
    • Industrial Property Rights Holder
      学校法人順天堂
    • Industrial Property Number
      2012-105132
    • Filing Date
      2012-05-02
    • Related Report
      2013 Final Research Report
    • Overseas

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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