Tlanslating podocyte biology into new therapys and examinations for podocyte injury
Project/Area Number |
23591201
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
|
Research Institution | Kyoto University (2013) Juntendo University (2011-2012) |
Principal Investigator |
ASANUMA KATSUHIKO 京都大学, 医学(系)研究科(研究院), 准教授 (60449064)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ポドサイト / 腎障害 / ネフローゼ症候群 / スリット膜 / アポトーシス / 慢性腎臓病 / Notch2 / dendrin / YAP2 / 活性型ビタミンD |
Research Abstract |
Glomerular visceral epithelial cells, also known as podocytes, serve as the final barrier to urinary protein loss. Podocyte injury may cause podocyte detachment, which leads to glomerulosclerosis. In our established model mice, severe podocyte injury induced podocyte loss and apoptosis, and glomeruloscrelosis. Using the mice model, we reported that treatment of 220oxa-calcitriol and Nothc2 agonist antibody suppressed podocyte loss and apoptosis. Furthermore, we reported that the measurement of urinary podocalyxin may be a useful biomarker to determine activity of IgA nephropathy and the effectiveness of corticosteroid treatment to IgA nephropathy.
|
Report
(4 results)
Research Products
(73 results)
-
[Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy2014
Author(s)
Trejo JAO, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y
-
Journal Title
Biochem Biophys Res Commun
Volume: 446
Pages: 1190-6
Related Report
-
[Journal Article] Notch2 activation ameliorates nephrosis.2014
Author(s)
Tanaka E, Asanuma K, Kim E, Sasaki Y, Oliva Trejo JA, Seki T, Nonaka K, Asao R, Nagai-Hosoe Y, Akiba-Takagi M, Hidaka T, Takagi M, Koyanagi A, Mizutani S, Yagita H, Tomino Y.
-
Journal Title
Nature communications
Volume: 5
Issue: 1
Pages: 3296-3296
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.2014
Author(s)
Oliva Trejo JA, Asanuma K, Kim EH, Takagi-Akiba M, Nonaka K, Hidaka T, Komatsu M, Tada N, Ueno T, Tomino Y.
-
Journal Title
Biochemical and biophysical research communications
Volume: 446(4)
Issue: 4
Pages: 1190-1196
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patoents with IgA nephropathy2013
Author(s)
Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y
-
Journal Title
Nephrol Dial Transplant
Volume: 28(F K, K A contributed equally to this publication)
Pages: 1762-72
Related Report
-
-
-
-
-
-
[Journal Article] Risk of overexpression of kidney function using GFR-estimating equations in patients with low insulin clearance2012
Author(s)
Nakata J, Ohsawa I, Onda K, tanimoto M, Kusaba G, Takeda Y, Kobayashi N, Asanuma K, Tanaka Y, Sato M, Inami Y, Suzuki H, Suzuki H, Masuda A, Nonaka K, Sasaki Y, Hisada A, Hamada C, Horikoshi S, Tomino Y
-
Journal Title
J clin Lab Anal
Volume: 26
Pages: 248-253
Related Report
-
[Journal Article] N-type calcium channel inhibition with Cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition2012
Author(s)
Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A
-
Journal Title
J Pharmacol Sci
Volume: 119
Pages: 359-67
NAID
Related Report
-
[Journal Article] Relationships between levels of urinary podocalyxin, number of urinary podocytes and histological injury in adult patients with IgA nephropathy2012
Author(s)
Asao R, Asanuma K, Kodama F, Akiba-Takagi M, Hosoe-Nagai Y, Seki T, Takeda Y, Ohsawa I, Mano S, Matsuoka K, Kurosawa H, Ogasawara S, Hirayama Y, Sekine S, Horikoshi S, Hara M, Tomino Y
-
Journal Title
Clin J Am Soc Nephrol
Volume: 7(R A, K A contributed equally to this publication)
Pages: 1385-93
Related Report
-
-
[Journal Article] Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patoents with IgA nephropathy.2012
Author(s)
Kodama F, Asanuma K, Takagi M, Hidaka T, Asanuma E, Fukuda H, Seki T, Takeda Y, Hosoe-Nagai Y, Asao R, Horikoshi S, Tomino Y.
-
Journal Title
Nephrol Dial Transplant.
Volume: 28
Pages: 1762-72
Related Report
Peer Reviewed
-
[Journal Article] N-type calcium channel inhibition with Cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition.2012
Author(s)
Lei B, Nakano D, Fujisawa Y, Liu Y, Hitomi H, Kobori H, Mori H, Masaki T, Asanuma K, Tomino Y, Nishiyama A
-
Journal Title
J Pharmacol Sci.
Volume: 119
Pages: 359-67
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Effects of 22-oxa-calcitriol on podocyte injury in adriamycin-induced nephrosis2011
Author(s)
Lydia A, Asanuma K, Nonaka K, Takagi M, Jeong K-H, Kodama F, Asao R, Asanuma E, Prodjosudjadi W, Tomino Y
-
Journal Title
Am J Nephrol
Volume: 35(A L, K A contributed equally to this publication)
Pages: 58-68
Related Report
-
-
[Journal Article] mTORC1 activation triggers the unfold protein response in podocytes and leads to nephritic syndrome2011
Author(s)
Ito N, Nishibori Y, Ito Y, Takagi H, Akimoto Y, Kudo A, Asanuma K, Sai Y, Miyamoto KI, Takenaka H, Yan K
-
Journal Title
Lab Invest
Volume: 91
Pages: 1584-1595
Related Report
-
[Journal Article] Dendrin location in podocytes is associated with the disease progression in animal and human glomerulopathy2011
Author(s)
Asanuma K, Akiba-Takagi M, Kodama F, Asao R, Nagai Y, Lydia A, Fukuda H, Tanaka E, Shibata T, Takahara H, Hidaka T, Asanuma E, Kominami E, Ueno T, Tomino Y
-
Journal Title
Am J Nephrol
Volume: 23
Pages: 537-549
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Relationship between Urinary Podocalyxin Level and Histological Activity in Patients with IgA Nephropathy2012
Author(s)
Rin Asao, Katsuhiko Asanuma, Fumiko Kodama, Miyuki Akiba-Takagi, Yoshiko Nagai-Hosoe, Takuto Seki, Yukihiko Takeda, Isao Ohsawa, Satoshi Mano, Kiyoshi Matsuoka, Hiroyuki Kurosawa, Shinya Ogasawara, Yoshiaki Hirayama, Satoshi, Sakari Sekine, Satoshi Horikoshi, Masanori Hara, Yasuhiko Tomino
Organizer
The 9^<th> inter national podocyte conference
Place of Presentation
Miami
Year and Date
2012-04-23
Related Report
-
[Presentation] Notch2 pathway reactivation ameliorates urinary protein and glomerular sclerosis in adriamycin nephropathy mice2012
Author(s)
Eriko Tanaka, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Yoshiko Hosoe, Miyuki Takagi, Alejandro Oliva, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino
Organizer
9th International Podocyte Conference
Related Report
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Notch2 pathway reactivation ameliorates urinary protein and glomerular sclerosis in adriamycin nephropathy mice.
Author(s)
Eriko Tanaka, Katsuhiko Asanuma, Kanae Nonaka, Takuto Seki, Rin Asao, Yoshiko Hosoe, Miyuki Takagi, Alejandro Oliva, Shuki Mizutani, Hideo Yagita, Yasuhiko Tomino.
Organizer
9th International Podocyte Conference.
Place of Presentation
Maiami
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-