Identification and analysis of genes influencing serum uric acid levels

• Project/Area Number: 23591205
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: ICHIDA Kimiyoshi 東京薬科大学, 薬学部, 教授 (80183169)
• Co-Investigator(Kenkyū-buntansha): JUTABHA Promsuk 獨協医科大学, 医学部, 助教 (90541748) ; KIMURA Toru 杏林大学, 医学部, 講師 (30433725)
• Co-Investigator(Renkei-kenkyūsha): HOSOYAMADA Makoto 帝京大学, 薬学部, 教授 (00291659) ; MATSUO Hirotaka 防衛医科大学校, 医学部, 講師 (00528292) ; NAKAMURA Makiko 東京薬科大学, 薬学部, 助教 (80447557) ; NAKAMURA Yoshihiro 防衛医科大学校, 医学部, 准教授 (60415255)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 高尿酸血症 / 痛風 / 尿酸トランスポーター / ABCG2 / 腎外排泄低下型高尿酸血症 / 排泄低下型高尿酸血症 / 産生過剰型高尿酸血症 / 発症年齢 / 腎負荷型高尿酸血症 / 低尿酸血症 / URAT1 / GLUT9 / URATv1

Research Abstract

A function of ABCG2, urate excretive transporter, is evaluated by the combination of the no-functional SNP, Q126X and the half functional SNP, Q141K. The estimated ABCG2 dysfunction leads to the urinary urate excretion increase and this mechanism was elucidated using Abcg2 knock-out mice. As a new mechanism for hyperuricemia, we demonstrated that hyperuricemia results from the intestinal urate excretion decrease via ABCG2, leading to urinary urate excretion increase (extra-renal urate underexcretion type hyperuricemia). We also indicated that ABCG2 dysfunction is related with early-onset gout and that the slight and mild dysfunctions mainly cause underexcretion type hyperuricemia, while severe dysfunction causes extra-renal urate underexcretion type hyperuricemia.

Research Products

• [Journal Article] A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout (2014)
  • Author(s): Sakiyama M, Matsuo H, Shimizu S, Nakashima H, Nakayama A, Chiba T, Naito M, Takada T, Suzuki H, Hamajima N, Ichida K, Shimizu T, Shinomiya N
  • Journal Title: Drug Metab Pharmacokinet Volume: 29(2) Pages: 208-10
  • NAID: 130004463357
• [Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility (2014)
  • Author(s): Sakiyama M, Matsuo H, Shimizu S, Chiba T, Nakayama A, Takada Y, Nakamura T, Takada T, Morita E, Naito M, Wakai K, Inoue H, Tatsukawa S, Sato J, Shimono K, Makino T, Satoh T, Suzuki H, Kanai Y, Hamajima N, Sakurai Y, Ichida K, Shimizu T, Shinomiya N
  • Journal Title: Hum Cell Volume: 27(1) Pages: 1-4
• [Journal Article] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload (2014)
  • Author(s): Matsuo H, Nakayama A, Sakiyama M, Chiba T, Shimizu S, Kawamura Y, Nakashima H, Nakamura T, Takada Y, Oikawa Y, Takada T, Nakaoka H, Abe J, Inoue H, Wakai K, Kawai S, Guang Y, Nakagawa H, Ito T, Niwa K, Yamamoto K, Sakurai Y, Suzuki H, Hosoya T, Ichida K, Shimizu T, Shinomiya N
  • Journal Title: Sci Rep Volume: 4 Pages: 3755-3755
• [Journal Article] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload (2014)
  • Author(s): Matsuo, H. Nakayama, A. Sakiyama, M. et al.
  • Journal Title: Sci Rep Volume: 4：3755 Issue: 1 Pages: 1-5
  • DOI: 10.1038/srep03755
  • Peer Reviewed
• [Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility (2014)
  • Author(s): Sakiyama, M. Matsuo, H. Shimizu, S. Chiba, T. Nakayama, A. Takada, Y. Nakamura, T. Takada, T. Morita, E. Naito, M. Wakai, K. Inoue, H. Tatsukawa, S. Sato, J. Shimono, K. Makino, T. Satoh, T. Suzuki, H. Kanai, Y. Hamajima, N. Sakurai, Y. Ichida, K. Shimizu, T. Shinomiya, N.
  • Journal Title: Hum Cell Volume: 27(1) Issue: 1 Pages: 1-4
  • DOI: 10.1007/s13577-013-0081-8
  • Peer Reviewed
• [Journal Article] Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia : biochemical, genetics and functional analysis (2013)
  • Author(s): Stiburkova B, Sebesta I, Ichida K, Nakamura M, Hulkova H, Krylov V, Kryspinova L, Jahnova H
  • Journal Title: Eur J Hum Genet Volume: 21(10) Pages: 1067-73
• [Journal Article] Common dysfunctional variants in ABCG2 are a major cause of early-onset gout (2013)
  • Author(s): Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N
  • Journal Title: Sci Rep Volume: 3 Pages: 2014-2014
• [Journal Article] Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility (2013)
  • Author(s): Nakayama A, Matsuo H, Shimizu T, Ogata H, Takada Y, Nakashima H, Nakamura T, Shimizu S, Chiba T, Sakiyama M, Ushiyama C, Takada T, Inoue K, Kawai S, Hishida A, Wakai K, Hamajima N, Ichida K, Sakurai Y, Kato Y, Shimizu T, Shinomiya N
  • Journal Title: Hum Cell Volume: 26(4) Pages: 133-6
• [Journal Article] Ependymal cells of the mouse brain express urate transporter 1 (URAT1) (2013)
  • Author(s): Tomioka NH, Nakamura M, Doshi M, Deguchi Y, Ichida K, Morisaki T, Hosoyamada M
  • Journal Title: Fluids Barriers CNS Volume: 10(1) Pages: 31-31
• [Journal Article] Common dysfunctional variants in ABCG2 are a major cause of early-onset gout. (2013)
  • Author(s): Matsuo, H. Ichida, K. Takada, T. et al.
  • Journal Title: Scientific reports Volume: 3：2014 Issue: 1 Pages: 2014-2014
  • DOI: 10.1038/srep02014
  • Peer Reviewed
• [Journal Article] A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility (2013)
  • Author(s): Nakayama, A. Matsuo, H. Shimizu, T. Ogata, H. Takada, Y. Nakashima, H. Nakamura, T. Shimizu, S. Chiba, T. Sakiyama, M. Ushiyama, C. Takada, T. Inoue, K. Kawai, S. Hishida, A. Wakai, K. Hamajima, N. Ichida, K. Sakurai, Y. Kato, Y. Shimizu, T. Shinomiya, N.
  • Journal Title: Hum Cell Volume: 26(4) Issue: 4 Pages: 133-6
  • DOI: 10.1007/s13577-013-0073-8
  • Peer Reviewed
• [Journal Article] Novel allelic variants and evidence for a prevalent mutation in URAT1 causing renal hypouricemia: biochemical, genetics and functional analysis. (2013)
  • Author(s): Stiburkova B, Sebesta I, Ichida K, et al
  • Journal Title: Eur J Hum Genet Volume: 21 Issue: 10 Pages: 1067-1073
  • DOI: 10.1038/ejhg.2013.3
  • Peer Reviewed
• [Journal Article] Ependymal cells of the mouse brain express urate transporter 1 (URAT1). (2013)
  • Author(s): Tomioka NH, Nakamura M, Doshi M, et al
  • Journal Title: Fluids Barriers CNS Volume: 10 Issue: 1 Pages: 31-31
  • DOI: 10.1186/2045-8118-10-31
  • Peer Reviewed
• [Journal Article] ウリカーゼ融合タンパク質を用いた細胞内尿酸検出法の開発 (2013)
  • Author(s): 中村 真希子、細山田 真, 市田 公美
  • Journal Title: 痛風と核酸代謝 Volume: ３７ Pages: 93-101
  • NAID: 130003388381
  • Peer Reviewed
• [Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia (2012)
  • Author(s): Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Inoue H, Okada C, Utsumi Y, Ikebuchi Y, Ito K, Nakamura M, Shinohara Y, Hosoyamada M, Sakurai Y, Shinomiya N, Hosoya T, Suzuki H
  • Journal Title: Nat Commun Volume: 3 Pages: 764-764
• [Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia (2012)
  • Author(s): Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada, et al (Hiroshi Suzuki)
  • Journal Title: Nature Communication Volume: 3 Issue: 1 Pages: 1-7
  • DOI: 10.1038/ncomms1756
  • Peer Reviewed
• [Journal Article] Molybdenum Cofactor Deficiency Mimics Cerebral Palsy: Differentiating Factors for Diagnosis. (2012)
  • Author(s): Kikuchi K
  • Journal Title: Pediatr Neurol Volume: 47 Issue: 2 Pages: 147-149
  • DOI: 10.1016/j.pediatrneurol.2012.04.013
  • Peer Reviewed
• [Journal Article] A Case of Hereditary Xanthinuria Type 1 Accompanied by Bilateral Renal Calculi (2012)
  • Author(s): Fujiwara Y
  • Journal Title: Internal Medicine Volume: 51 Issue: 14 Pages: 1879-1884
  • DOI: 10.2169/internalmedicine.51.6891
  • NAID: 130002062228
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Antihypertensive Effect of a Fixed−dose Combination of Losartan/Hydrochlorothiazide in Patients with Uncontrolled Hypertension: A Multicenter Study. (2012)
  • Author(s): Hosoya T
  • Journal Title: Clin Exp Nephrol Volume: 16 Issue: 2 Pages: 269-278
  • DOI: 10.1007/s10157-011-0564-4
  • Peer Reviewed
• [Journal Article] Identification of a Xanthinuria Type I Case with Mutations of Xanthine Dehydrogenase in an Afghan Child. (2012)
  • Author(s): Nakamura M
  • Journal Title: Clin Chim Acta Volume: 414 Pages: 158-160
  • DOI: 10.1016/j.cca.2012.08.011
  • Peer Reviewed
• [Journal Article] Fluoresceinを用いた尿酸トランスポーター機能評価法の検討. (2012)
  • Author(s): 中村 真希子
  • Journal Title: 痛風と核酸代謝 Volume: 36 Pages: 87-94
  • NAID: 130003378906
  • Peer Reviewed
• [Journal Article] Novel homozygous insertion in SLC2A9 gene caused renal hypouricemia (2011)
  • Author(s): Stiburkova B, Ichida K, Sebesta I
  • Journal Title: Mol Genet Metab Volume: 102(4) Pages: 430-5
• [Journal Article] Prenatal brain disruption in molybdenum cofactor deficiency (2011)
  • Author(s): Carmi-Nawi N, Malinger G, Mandel H, Ichida K, Lerman-Sagie T, Lev D
  • Journal Title: J Child Neurol Volume: 26(4) Pages: 460-4
• [Journal Article] Simultaneous determination of selenomethionine enantiomers in biological fluids by stable isotope dilution gas chromatography-mass spectrometry (2011)
  • Author(s): Matsukawa T, Hasegawa H, Shinohara Y, Kobayashi J, Shinohara A, Chiba M, Ichida K, Yokoyama K
  • Journal Title: J Chromatogr B Analyt Technol Biomed Life Sci Volume: 879(29) Pages: 3253-8
• [Journal Article] Two cases of nephrotic syndrome (NS)-induced acute kidney injury (AKI) associated with renal hypouricemia (2011)
  • Author(s): Takeda Y, Abe A, Nakanishi S, Umezu M, Hirano K, Hayakawa H, Ohno I, Ichida K, Yamaguchi Y, Hosoya T, Fukagawa M
  • Journal Title: Clin Nephrol Volume: 76(1) Pages: 78-82
• [Journal Article] Two cases of nephrotic syndrome (NS)-induced acute kidney injury (AKI) associated with renal hypouricemia. (2011)
  • Author(s): Takeda Y
  • Journal Title: Clin Nephrol Volume: 76 Pages: 78-82
  • Peer Reviewed
• [Journal Article] ABCG2/BCRP dysfunction as a major cause of gout (2011)
  • Author(s): H.Matsuo, T.Takada, K.Ichida, T.Nakamura, A.Nakayama, H.Suzuki, T.Hosoya, N.Shinomiya
  • Journal Title: Nucleosides Nucleotides Nucleic Acids Volume: 30 Issue: 12 Pages: 1117-1128
  • DOI: 10.1080/15257770.2011.633954
  • Peer Reviewed
• [Journal Article] 遺伝性低尿酸血症 (2011)
  • Author(s): 市田 公美
  • Journal Title: 日腎誌 Volume: 53 Pages: 142-5
  • NAID: 10029736365
  • Peer Reviewed
• [Presentation] ABCG2 dysfunction increases the risk of renal overload hyperuricemia (2013)
  • Author(s): Matsuo H, Takada T, Nakayama A, Shimizu T, Sakiyama M, Hosoya T, Shinomiya N, Ichida K
  • Organizer: 15th International Symposium on Purine and Pyrimidine Metabolism in Man
  • Place of Presentation: Madrid, Spain
• [Presentation] Dysfunction of a urate exporter ABCG2 as a major risk factor of hyperuricemia and gout (2013)
  • Author(s): Takada T, Ichida K, Matsuo H, Nakayama A, Suzuki H
  • Organizer: 15th International Symposium on Purine and Pyrimidine Metabolism in Man
  • Place of Presentation: Madrid, Spain
• [Presentation] Common Dysfunctional Variants of ABCG2 Decrease Extra-renal Urate Excretion and Cause Hyperuricemia (2013)
  • Author(s): Ichida K, Matsuo H, Takada T, Nakayama A, Shimizu T, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Sakurai Y, Shinomiya N, Suzuki H, Hosoya T
  • Organizer: The 2nd International Congress on Personalized Medicine
  • Place of Presentation: Paris, France
• [Presentation] ABCG2/BCRP dysfunction as a major risk factor of gout (2013)
  • Author(s): Takada T, Matsuo H, Ichida K, Nakayama A, Suzuki H
  • Organizer: BioMedical Transporters 2013
  • Place of Presentation: St. Moritz, Switzerland
• [Presentation] Common dysfunctional variants of ABCG2 cause renal overload hyperuricemia (2013)
  • Author(s): Matsuo H, Takada T, Nakayama A, Shimizu T, Nakashima H, Nakamura T, Takada Y, Hosoya T, Shinomiya N, Ichida K
  • Organizer: Symposium of the Asia Pacific League of Associations for Rheumatology 2013
  • Place of Presentation: Bali, Indonesia
• [Presentation] Common dysfunctional variants of urate exporter gene ABCG2/BCRP are a major cause of early-onset gout (2013)
  • Author(s): Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Shimizu S, Sakiyama M, Chiba T, Hamajima N, Sakurai Y, Shinomiya N
  • Organizer: The American Society of Human Genetics 63rd Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] A common mechanism of gout/hyperuricemia with decreased urate excretion from intestine (2013)
  • Author(s): Nakayama A, Matsuo H, Hosoya T, Shinomiya N, Ichida K
  • Organizer: 第57回日本リウマチ学会総会・学術集会/第22回国際リウマチシンポジウム
  • Place of Presentation: 京都
• [Presentation] OAT4遺伝子変異は腎排泄低下型の痛風と関連する (2013)
  • Author(s): 崎山真幸,松尾洋孝,清水聖子,中山昌喜,髙田龍平,市田公美,清水徹,四ノ宮成祥
  • Organizer: 第47回日本痛風・核酸代謝学会総会
  • Place of Presentation: 神戸
• [Presentation] ABCG2遺伝子の機能低下型変異は若年発症痛風の主要な病因である (2013)
  • Author(s): 中山昌喜,松尾洋孝,市田公美,髙田龍平,高田雄三,井上寛規,清水聖子,崎山真幸,細山田真,横尾隆,細谷龍男,清水徹,四ノ宮成祥
  • Organizer: 第47回日本痛風・核酸代謝学会総会
  • Place of Presentation: 神戸
• [Presentation] 5/6腎摘除ラットにおけるメチオニン‐ホモシステイン代謝系の解析 (2013)
  • Author(s): 長谷川 弘, 田村 優香, 重永 恵理, 篠原 佳彦, 市田 公美
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] 腸管尿酸排泄低下に起因する新たな「腎負荷型」高尿酸血症の解明 (2013)
  • Author(s): 中村 真希子, 松尾 洋孝,高田 龍平, 中山 昌喜, 清水 徹, 細山田 真, 四ノ宮 成祥, 鈴木 洋史, 細谷 龍男, 市田 公美
  • Organizer: 第56回日本腎臓学会学術総会
  • Place of Presentation: 東京
• [Presentation] 蛍光化合物輸送を指標とした尿酸トランスポーターURAT1機能解析法の開発 (2013)
  • Author(s): 中村 真希子, 足立 匠, 松尾 広大, 市田 公美
  • Organizer: 第8回トランスポーター研究会年会
  • Place of Presentation: 熊本
• [Presentation] HPRT欠損症：新たな日本人家系のHPRT1変異とPRPP濃度 (2013)
  • Author(s): 山田 裕一, 野村 紀子, 山農 亜里佐, 山田 憲一郎, 木村 礼子, 福士 大輔, 長谷川 弘, 中村 真希子, 市田 公美, 若松 延昭
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] メチオニン－ホモシステイン代謝サイクルに及ぼす腎部分摘除の影響 (2013)
  • Author(s): 長谷川 弘, 田村 優香, 重永 恵理, 上田 麻未, 松尾 和恵, 篠原 佳彦, 市田 公美
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜
• [Presentation] 尿酸排泄トランスポーターABCG2による高尿酸血症治療薬輸送の検討 (2013)
  • Author(s): 浅見 友一, 小池 晋太郎, 豊田 優, 高田 龍平, 中村 真希子, 長谷川 弘, 市田 公美
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] 血中尿酸低下による活性酸素過剰の運動後急性腎不全への関与の検討 (2013)
  • Author(s): 大塚 恵子, 大澤 朱子, 五十嵐 則紀, 中村 真希子, 市田 公美
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Lesch-Nyhan病に伴う脳内ZMPの増加と神経症状の関連性に対する検討 (2013)
  • Author(s): 清水 考大, 杉本 大輔, 篠原 佳彦, 中村 真希子, 市田 公美
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Uricase融合タンパク質を用いた尿酸トランスポーター機能解析法の開発 (2013)
  • Author(s): 光石 昌平, 山根 千佳, 細野 彩奈, 中村 真希子, 市田 公美
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] Novel common mechanism of hyperuricemia by decreased extra-renal urate excretion (2012)
  • Author(s): Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Utsumi Y, Nakamura M, Hosoyamada M, Sakurai Y, Shinomiya N, Hosoya T, Suzuki H
  • Organizer: European Human Genetics Conference 2012
  • Place of Presentation: Nürnberg, Germany
• [Presentation] Common dysfunctional variants of ABCG2 decrease extra-renal urateexcretion and cause hyperuricemia (2012)
  • Author(s): Matsuo H, Takada T, Nakayama A, Shimizu T, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Utsumi Y, Ogata H, Nakamura M, Sakurai Y, Hosoya T, Shinomiya N, Suzuki H, Ichida K
  • Organizer: 62nd The American Society of Human Genetics Annual Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] 腎外排泄低下型高尿酸血症 (2012)
  • Author(s): 市田公美
  • Organizer: 第45回日本痛風・核酸代謝学会総会
  • Place of Presentation: 東京
• [Presentation] 尿酸の腸管排泄低下は高尿酸血症の主要な新規機序である (2012)
  • Author(s): 市田公美,松尾洋孝,高田龍平,中山昌喜,清水徹,春日裕志,中島宏,中村好宏,高田雄三,河村優輔,内海由貴,中村真希子,櫻井裕,細谷龍男,四ノ宮成祥,鈴木洋史
  • Organizer: 第99回日本消化器病学会総会
  • Place of Presentation: 鹿児島
• [Presentation] Novel common mechanism of hyperuricemia by decreased extra−renal urate excretion (2012)
  • Author(s): Ichida K
  • Organizer: European Human Genetics Conference 2012
  • Place of Presentation: Nürnberg, Germany
• [Presentation] Molybdenum cofactor deficiency type B; Clinical, biochemical and neuroimaging features of five patients with two novel mutations. (2012)
  • Author(s): Hismi B
  • Organizer: Society for the Study of Inborn Errors of Metabolism Annual Symposium 2012
  • Place of Presentation: Birmingham, UK
• [Presentation] Common dysfunctional variants of ABCG2 decrease extra−renal urateexcretion and cause hyperuricemia. (2012)
  • Author(s): Matsuo H
  • Organizer: 62nd The American Society of Human Genetics Annual Meeting
  • Place of Presentation: San francisco, USA
• [Presentation] 大規模健診サンプルを用いたABCG2 遺伝子多型と血清尿酸値との関連解析 (2012)
  • Author(s): 中山 昌喜
  • Organizer: 第45回日本痛風・核酸代謝学会学術集会
  • Place of Presentation: 奈良
• [Presentation] Changes in uric acid levels with dysfunctional ABCG2 and novel pathophysiological model of hyperuricemia (2011)
  • Author(s): Nakayama A, Matsuo H, Ichida K, Takada T, Takada Y, Nakashima H, Nakamura T, Sakurai Y, Hamajima N, Suzuki H, Shinomiya N
  • Organizer: 4th Federation of European Biochemical Societies (FEBS) special meeting on ATP-Binding Cassette (ABC) Proteins (ABC2012)
  • Place of Presentation: Innsbruck, Austria
• [Presentation] 新規ヒト尿酸/有機酸トランスポーターURAT2の分子同定 (2011)
  • Author(s): 安西尚彦,Jutabha P,木村徹,北村健一郎,市田公美
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 大規模健診サンプルを用いたABCG2遺伝子多型と血清尿酸値との関連解析 (2011)
  • Author(s): 中山昌喜,松尾洋孝,市田公美,高田龍平,井上寛規,岡田千沙,四ノ宮成祥
  • Organizer: 第45回日本痛風・核酸代謝学会学術集会
  • Place of Presentation: 奈良