| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
We used Klotho overexpressing mice and Akita mice(a spontaneous insulin secretion deficiency diabetes model) in this experiment were.At 20 weeks of age, we compared albuminuria renal tissue, kidney calpain activity. Albuminuria appeared at 20 weeks of age Akita mice, but it was significantly inhibited by Klotho overexpression. Glomerular injury was significantly suppressed compared to Akita mouse. Klotho inhibits the calpain activation, and inhibits albuminuria by diabetes. Klotho replacement therapy is effective against diabetic nephropathy treatment.
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