Cytoprotective actions of Klotho in oxidative damages of proximal tubular epithelial cells caused by high glucose
| Project/Area Number |
23591208
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Minoru 川崎医科大学, 医学部, 准教授 (70449891)
KASHIHARA Naoki 川崎医科大学, 医学部, 教授 (10233701)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腎臓学 |
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| Research Abstract |
We used Klotho overexpressing mice and Akita mice(a spontaneous insulin secretion deficiency diabetes model) in this experiment were.At 20 weeks of age, we compared albuminuria renal tissue, kidney calpain activity. Albuminuria appeared at 20 weeks of age Akita mice, but it was significantly inhibited by Klotho overexpression. Glomerular injury was significantly suppressed compared to Akita mouse. Klotho inhibits the calpain activation, and inhibits albuminuria by diabetes. Klotho replacement therapy is effective against diabetic nephropathy treatment.
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Report
(4 results)
Research Products
(27 results)
