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Role of ADMA in acute kidney injury

Research Project

Project/Area Number 23591210
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKurume University

Principal Investigator

SEIJI Ueda  久留米大学, 医学部, 准教授 (80322593)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords急性腎障害 / 内皮障害 / ADMA / 造影剤腎症 / 虚血再還流
Research Abstract

Injury to the renal vasculature plays important roles in the pathogenesis of acute kidney injury (AKI). Asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, could enhance kidney injury during AKI by causing vascular damage. (Basic research) We investigated the roles of ADMA in AKI using ischemia/reperfusion (I/R)-induced renal injury model mice. I/R injury-induced oxidative stress may reduce DDAH, a degradading enzyme for ADMA, expression and cause ADMA accumulation, which may contribute to capillary loss and tubular necrosis in the kidney. (Clinical research) We next investigated whether ADMA could be a predictor for AKI in 55 patients undergoing elective coronary angiography (CAG). Although no cases of obvious AKI assessed by changes in creatinine levels were identified, administration of contrast medium caused significant increases in plasma ADMA levels. Further, eleveted ADMA was tended to correlated to annual eGFR loss in these subjects.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury2014

    • Author(s)
      Nakayama Y, UedaS, Yamagishi S, Okuda S
    • Journal Title

      Kidney Int

      Volume: 85 Pages: 570-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of asymmetric dimethylarginine incardiorenal syndrome2014

    • Author(s)
      Ueda S, Yamagishi S, Okuda S
    • Journal Title

      Curr Pharm Design

      Volume: 20 Pages: 2448-55

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.2014

    • Author(s)
      Nakayama Y, Ueda S, et al.
    • Journal Title

      Kidney Int

      Volume: 85 Issue: 3 Pages: 570-578

    • DOI

      10.1038/ki.2013.398

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome.2014

    • Author(s)
      Ueda S, et al.
    • Journal Title

      Curr Pharm Des

      Volume: 20 Pages: 2448-2455

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction2013

    • Author(s)
      Ando R, Ueda S, Yamagishi S, Miyazaki H, Kaida Y, Kaifu K, Yokoro M, Nakayama Y, Obara N, Fukami K, Takeuchi M, Okuda S
    • Journal Title

      Diab Vasc Dis Res

      Volume: 10(5) Pages: 436-41

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of advanced glycation end product–induced asymmetric dimethylarginine generation in endothelial dysfunction2013

    • Author(s)
      Ando R, Ueda S, et al.
    • Journal Title

      Diabetes & Vascular Disease Research

      Volume: 印刷中 Issue: 5 Pages: 436-441

    • DOI

      10.1177/1479164113486662

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of asymmetric dimethylargine in cardiorenal syndrome2013

    • Author(s)
      Ueda S, et al.
    • Journal Title

      Current Pharmaceutical Design

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of eNOS Phosphorylation Mediates Endothelial Dysfunction in Renal Failure : New Effect of Asymmetric Dimethylarginine2012

    • Author(s)
      Kajimoto H, Kai H, Aoki H, Yasuoka S, Anegawa T, Aoki Y, Ueda S, Okuda S, Imaizumi T
    • Journal Title

      Kidney Int

      Volume: 81 Pages: 762-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome2012

    • Author(s)
      Kaida Y, Ueda S, Yamagishi SI, Nakayama Y, Ando R, Iwatani R, Fukami K, Okuda S
    • Journal Title

      Life Sci

      Volume: 24;91(9-10) Pages: 301-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pravastatin inhibits advanced glycation end products (AGEs)‐induced proximal tubular cell apoptosis and injury by reducing receptor for AGEs (RAGE) level2012

    • Author(s)
      Ishibashi Y, Yamagishi S, Matsui T, Ohta K, Tanoue R, Takeuchi M, Ueda S, Nakamura K, Okuda S
    • Journal Title

      Metabolism

      Volume: 61(8) Pages: 1067-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes2012

    • Author(s)
      Yamagishi SI, Maeda S, Matsui T, Ueda S, Fukami K, Okuda S
    • Journal Title

      Biochim Biophys Acta

      Volume: 1820(5) Pages: 663-71

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteinuria elevates asymmetric dimethylarginine levels via protein arginine methyltransferase-1 overexpression in a rat model of nephrotic syndrome.2012

    • Author(s)
      Kaida Y, Okuda S, et al.
    • Journal Title

      Life Sci.

      Volume: 91 Issue: 9-10 Pages: 301-305

    • DOI

      10.1016/j.lfs.2012.06.015

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of eNOS Phosphorylation Mediates Endothelial Dysfunction in Renal Failure : New Effect of Asymmetric Dimethylarginine2012

    • Author(s)
      Kajimoto H, Kai H, Imaizumi T(他6人9番目)
    • Journal Title

      Kidney International

      Volume: 81 Issue: 8 Pages: 762-768

    • DOI

      10.1038/ki.2011.476

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of ADMA with severity of kidney injury and decline in kidney function in IgA nephropathy2011

    • Author(s)
      Fujimi-Hayashida A, Ueda S, Yamagishi S, Kaida Y, Ando R, Nakayama Y, Fukami K, Okuda S
    • Journal Title

      Am J Nephrol

      Volume: 33 Pages: 1-6

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tissue level of advanced glycation end products is an independent determinant of high-sensitivity C-reactive protein levels in haemodialysis patients2011

    • Author(s)
      Nagano M, Fukami K, Yamagishi S, Sakai K, Kaida Y, Matsumoto T, Hazama T, Tanaka M, Ueda S, Okuda S
    • Journal Title

      Nephrology (Carlton)

      Volume: 16 Pages: 299-303

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of ADMA with severity of kidney injury and decline in kidney function in IgA nephropathy.2011

    • Author(s)
      Fujimi-Hayashida A, Ueda S, Yamagishi S, Kaida Y, Ando R, Nakayama Y, Fukami K, Okuda S.
    • Journal Title

      Am J Nephrol

      Volume: 33 Pages: 1-6

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 心腎連関におけるジメチルアルギニンの役割2011

    • Author(s)
      上田誠二、奥田誠也
    • Organizer
      日本腎臓学会西部学術大会
    • Place of Presentation
      徳島
    • Year and Date
      2011-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 心腎連関におけるジメチルアルギニンの役割

    • Author(s)
      上田誠二、奥田誠也
    • Organizer
      日本腎臓学会西部学術大会(招待講演)
    • Place of Presentation
      徳島
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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