Role of ADMA in acute kidney injury
| Project/Area Number |
23591210
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kurume University |
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Principal Investigator |
SEIJI Ueda 久留米大学, 医学部, 准教授 (80322593)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 急性腎障害 / 内皮障害 / ADMA / 造影剤腎症 / 虚血再還流 |
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| Research Abstract |
Injury to the renal vasculature plays important roles in the pathogenesis of acute kidney injury (AKI). Asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, could enhance kidney injury during AKI by causing vascular damage. (Basic research) We investigated the roles of ADMA in AKI using ischemia/reperfusion (I/R)-induced renal injury model mice. I/R injury-induced oxidative stress may reduce DDAH, a degradading enzyme for ADMA, expression and cause ADMA accumulation, which may contribute to capillary loss and tubular necrosis in the kidney. (Clinical research) We next investigated whether ADMA could be a predictor for AKI in 55 patients undergoing elective coronary angiography (CAG). Although no cases of obvious AKI assessed by changes in creatinine levels were identified, administration of contrast medium caused significant increases in plasma ADMA levels. Further, eleveted ADMA was tended to correlated to annual eGFR loss in these subjects.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Involvement of advanced glycation end product-induced asymmetric dimethylarginine generation in endothelial dysfunction2013
Author(s)
Ando R, Ueda S, Yamagishi S, Miyazaki H, Kaida Y, Kaifu K, Yokoro M, Nakayama Y, Obara N, Fukami K, Takeuchi M, Okuda S
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Journal Title
Diab Vasc Dis Res
Volume: 10(5)
Pages: 436-41
Related Report
Peer Reviewed
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