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Development of artificial kidney for removal of anionic uremic toxins

Research Project

Project/Area Number 23591212
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionNippon Medical School (2012-2015)
University of Tsukuba (2011)

Principal Investigator

TSURUOKA Shuichi  日本医科大学, 医学(系)研究科(研究院), 教授 (50285798)

Co-Investigator(Kenkyū-buntansha) YAMAGATA Kunihiro  筑波大学, 医療医学系, 教授 (90312850)
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords尿毒症性物質 / インドキシル硫酸 / バイオ人工腎臓 / 尿細管輸送
Outline of Final Research Achievements

We found that anionic uremic toxins such as indoxyl sulfate, p-cresyl sulphate, and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid stimulated proliferation of cultured smooth vascular cells via phosphorylation of proteins related to cell signaling (such as MAP kinase). We also established cultured renal tubular cells with high transport rate of these toxins. We further established the systems of artificial kidney with high capacity to remove these toxins.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (5 results) (of which Invited: 2 results)

  • [Journal Article] SDF1 induction by acidosis from principal cells regulates intercalated cell subtype distribution.2015

    • Author(s)
      Schwartz GJ, Gao X, Tsuruoka S, Purkerson JM, Peng H, D'Agati V, Picard N, Eladari D, Al-Awqati Q.
    • Journal Title

      J Clin Invest.

      Volume: 125 Issue: 12 Pages: 4365-4374

    • DOI

      10.1172/jci80225

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical benefit of the change of dialysate calcium concentration from 3.0 to 2.75 mEq/L.2014

    • Author(s)
      Otsukua T, Ohno D, Murasawa T, Sakai S, Tsuruoka S.
    • Journal Title

      Ther Apher Dial.

      Volume: 18 Pages: 181-184

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dialyzability and pharmacokinetics of sitafloxacin following multiple oral dosing in infected hemodialysis patients.2013

    • Author(s)
      Tsuruoka S, Yokota N, Hayasaka T, Saito T, Yamagata K.
    • Journal Title

      Ther Apher Dial

      Volume: 17 Issue: 3 Pages: 319-324

    • DOI

      10.1111/j.1744-9987.2012.01150.x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腎臓における尿毒素排泄機構2013

    • Author(s)
      鶴岡秀一
    • Journal Title

      日医大医会誌

      Volume: 9 Pages: 235-235

    • Related Report
      2013 Research-status Report
  • [Journal Article] Inhibition of CYP3A4 by 6',7'-dihydroxybergamottin in human CYP3A4 over-expressed hepG2 cells2012

    • Author(s)
      Araki N, Tsuruoka S, Hasegawa G, Yanagihara H, Omasa T, Enosawa S, Yamazoe Y, Fujimura A.
    • Journal Title

      J Pharm Pharmacol.

      Volume: 64 Pages: 1715-1721

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 薬剤性腎障害に対する早期マーカー探索の試み2014

    • Author(s)
      鶴岡秀一、荒川裕輔、藤村昭夫
    • Organizer
      第44回日本腎臓学会東部学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Dialyzability and pharmacokinetics of sitafloxacin following multiple oral dosing in infected hemodialysis patients2012

    • Author(s)
      Tsuruoka S, Yokota N, Hayasaka T, Saito T, Yamagata K.
    • Organizer
      2012 Renal week, American Society of Nephrology 45h Annual meeting.
    • Place of Presentation
      San Diego CA, USA,
    • Related Report
      2012 Research-status Report
  • [Presentation] Dialyzability and pharmacokinetics of oral levofloxacin in infected hemodialysis patients.2011

    • Author(s)
      Tsuruoka S, Hayasaka T, Yokota N, Saito T, Yamagata K.
    • Organizer
      2011 Renal week, American Society of Nephrology 44th Annual meeting.
    • Place of Presentation
      Philadelphia, PA, USA,
    • Related Report
      2011 Research-status Report
  • [Presentation] 間質性腎炎

    • Author(s)
      鶴岡秀一
    • Organizer
      第43回日本腎臓学会東部学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 維持透析患者におけるシタフロキサシンの透析性および薬物動態

    • Author(s)
      鶴岡秀一、横田徳継、早坂常江、斎藤鉄男、山縣邦弘
    • Organizer
      第58回日本透析医学会学術集会・総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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