| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The pathophysiology of salt-sensitive hypertension and its related organ damage were investigated in view point of epigenetic modifications. We have reported histone modification leads to salt-sensitive hypertension and in addition to it, we revealed that micro RNA regulates several genes which are regulators for oxidative stress and cause organ damages. And microRNA can be used for a tool to treat or prevent organ damages in salt-sensitive hypertension.
In human study, we preliminary investigated that cells in urine can be used to detect tubular function and may be useful to diagnose salt-sensitivity.
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