The systemic NAD world in chronic kidney disease
Project/Area Number |
23591218
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Kidney internal medicine
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Research Institution | The University of Tokushima |
Principal Investigator |
TATSUMI Sawako 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80420545)
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Co-Investigator(Kenkyū-buntansha) |
KIDO Shinsuke 徳島大学, 大学院ヘルスバイオサイエンス研究部, 特任助教 (30437652)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | リン / ニコチンアミド / NAD / 慢性腎臓病 / リン代謝 |
Research Abstract |
This study determines the presence of the new phosphate(Pi)metabolic pathway through the nicotinamide phosphoribosyltransferase(Nampt)as the first rate-limiting enzyme in converting NAM to NAD.The activation of Nampt caused the significantly increased levels of urinary Pi excretion and the decreased levels of intestinal Pi absorption.The present data suggest that the cause of hypophosphatemia and hyperphosphaturia observed after 70% hepatectomy is caused by abnormal Nampt/NAM activation in the liver and kidney. These result shows presence of the liver-kidney axsis in Pi metabolism. We examine a mechanism to do constantly the Pi/Ca ratio through Nampt.We think these research may be contribute to the prevention of cardiovascular disease development of patients with chronic renal disease.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet2014
Author(s)
Ohnishi R, Segawa H, Ohmoto T, Sasaki S, Hanazaki A, Mori A, Ikuta K, Furutani J, Kawakami E, Tatsumi S, Hamada Y, Miyamoto K
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Journal Title
J Med Invest
Volume: 61(1.2)
Pages: 162-170
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet.2014
Author(s)
Ohnishi R, Segawa H, Ohmoto T, Sasaki S, Hanazaki A, Mori A, Ikuta K, Furutani J, Kawakami E, Tatsumi S, Hamada Y, Miyamoto K.
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Journal Title
J Med Invest.
Volume: 61(1.2)
Pages: 162-170
NAID
Related Report
Peer Reviewed
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[Journal Article] Molecular Mechanisms of Cadmium-Induced Fibroblast growth Factor 23 Upregulation in Osteoblast-Like Cells.2014
Author(s)
Kido S, Fujihara M, Nomura K, Sasaki S, Mukai R, Ohnishi R, Kaneko I, Segawa H, Tatsumi S, Izumi H, Kohno K, Miyamoto KI.
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Journal Title
Toxicol Sci.
Volume: Apr 19
Related Report
Peer Reviewed
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[Journal Article] Identification and functional analysis of a splice variant of mouse sodium-dependent phosphate transporter Npt2c2012
Author(s)
Kuwahara S, Aranami F, Segawa H, Onitsuka A, Honda N, Tominaga R, Hanabusa E, Kaneko I, Yamanaka S, Sassaki S, Ohi A, Nomura K, Tatsumi S, Kido S, Ito M, Miyamoto K
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Journal Title
J Med Invest
Volume: 59(1.2)
Pages: 116-126
NAID
URL
Related Report
Peer Reviewed
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[Presentation] 骨とリン利尿因子2013
Author(s)
辰巳佐和子,木戸慎介,瀬川博子,宮本賢一
Organizer
第58回日本透析医学会学術集会・総会
Place of Presentation
福岡国際会議場(福岡県)
Year and Date
2013-06-21
Related Report
Invited
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[Presentation] 肝臓切除患者における低リン血症発症機構の解明.2013
Author(s)
野村憲吾,辰巳佐和子,宮川淳美,岡奈都紀,塩崎雄治,木戸慎介,瀬川博子,佐野光枝,福渡努, 柴田克己,宮本賢一.
Organizer
第67回日本栄養・食糧学会大会
Place of Presentation
名古屋大学東山キャンパス(愛知県)
Related Report
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[Presentation] 骨とリン利尿因子.2013
Author(s)
辰巳佐和子,木戸慎介,瀬川博子,宮本賢一.
Organizer
第58回日本透析医学会学術集会・総会
Place of Presentation
福岡国際会議場(福岡県)
Related Report
Invited
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[Presentation] Mechanisms of hyperphosphatemia in the osteocyte-abelated mice2012
Author(s)
Tatsumi S, Kamatani T, Nomura K, Yoshimi A, Shiozaki Y, Sasaki S, Manabe M, Kido S, Segawa H, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
San Diego Convention Center, CA,USA
Year and Date
2012-11-02
Related Report
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[Presentation] Post-Hepatectomy Hypophosphatemia in Rats2011
Author(s)
Nomura K, Tatsumi S, Shiozaki Y, Yamaguchi S, Kamatani T, Segawa H, Kido S, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
Pennsylvania Convention Center in Philadelphia,USA
Year and Date
2011-11-12
Related Report
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[Presentation] Role of Sodium-Dependent Phosphate(Pi)Transporter(Npt2b)on Salivary Pi Secretion2011
Author(s)
Segawa H, Mukai T, Ohnishi S, Sasaki S, Ohi A, Kuwahara S, Kido S, Tatsumi S, Ishikawa Y, Ueda O, Horiba N, Jishage K, Fukushima N, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
Pennsylvania Convention Center in Philadelphia,USA
Year and Date
2011-11-11
Related Report
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[Presentation] Molecular Consequences of the SLC34A3 Mutations of Hereditary Hypophosphatemic Rickets with Hypercalciuria(HHRH)2011
Author(s)
Ohi A, Haito Sugino S, Ito M, Shiozaki Y, Nomura K,Kusaka Y, Sasaki S, Ohnishi S, Yamaguchi S, Kido S, Tatsumi S,Segawa H, Miyamoto K
Organizer
Americal Society of Nephrology
Place of Presentation
Pennsylvania Convention Center in Philadelphia,USA
Year and Date
2011-11-10
Related Report
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[Book] 日本消化吸収学会雑誌2012
Author(s)
桑原煩治,大井彰子,野村憲吾,辰巳佐和子,木戸慎介,瀬川博子,宮本賢一
Total Pages
11
Publisher
日本消化吸収学会(Vol.34 No.3)
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[Book] 循環器内科2012
Author(s)
辰巳佐和子,野村憲吾,釜谷達哉,宮本賢一
Publisher
科学評論社(Vol.71 No.3)
Related Report
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