Analyses of molecular mechanism of hypertensive cardio-renal relationships focusing on post-transcriptional regulations of ion-transporters.
| Project/Area Number |
23591221
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 高血圧 / 食塩感受性 / 尿細管 / レニン / アンジオテンシノーゲン / レニン・アンジオテンシン系 / 内分泌 / ENaC / ナトリウムチャンネル / Nedd4L / ナトリウム代謝 |
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| Research Abstract |
Our research revealed the genetic and biological significance of molecules involved in "Molecular pathogenesis of tubular mechanisms leading to salt-sensitive hypertension." Renal tubular epithelial cells, joined by tight junction with each other, were highly differentiated, forming a tubule lumen of the ureteric bud-derived embryologically. Our research to date, a renal tubular RA system, the ENaC working in aldosterone-sensitive distal tubule cell work as endogenous endocrine systems for maintaining homeostatis. We have established molecular pathogenesis models maintaining homeostasis by regulating sodium reabsorption and via its collapse leading to pathology of salt-sensitivity, developing hypertension.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Anti-interleukin-5 and multiple autoantibodies are associated with human atherosclerotic diseases and serum interleukin-5 levels2013
Author(s)
Ishigami T, Abe K, Aoki I, Minegishi S, Ryo A, Matsunaga S, Matsuoka K, Taleda H, Sawasaki T, Umemura S, Endoh Y.
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Journal Title
FASEB J
Volume: 27
Issue: 9
Pages: 3437-45
DOI
Related Report
Peer Reviewed
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[Journal Article] Impact of renal insufficiency on long-term clinical outcome in patients with heart failure treated by cardiac resynchronization therapy2012
Author(s)
Hosoda J, Ishikawa T, Matsushita K, Matsumoto K, Kimura Y, Miyamoto M, Ogawa H, Takamura T, Sugano T, Ishigami T, Uchino K, Kimura K, Umemura S
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Journal Title
J Cardiol
Volume: 60(4)(Epub 2012 Jul 2)(PubMed PMID:22763383)
Issue: 4
Pages: 301-5
DOI
Related Report
Peer Reviewed
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