| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Research Abstract |
Phosphorus is essential, but its excess shows the toxicity. This study is fundamental researches aiming at phosphorus toxicity conquest.
Firstly, I have estimated vascular calcification as the phosphorus toxicity in clinical study with hemodialysis patients. Secondary, I have tried to establish the phosphorus induced vascular calcification model in vitro to know the detail mechanism of vascular disorder by phosphorus. We have succeeded ex vivo vascular medial calcification model by the aortic tissue culture under high phosphorus condition 3.8mM for ten days. Next, I have made a research the phosphorus sensing system and/or phosphorus induced molecules. Fibroblast growth factor 23 (FGF23) derived from a bone has been explicated to play key role in phosphorus toxicity-induced vascular dysfunction. I am progressing the research to know the detail phosphorus sensing mechanism by FGF23 production and by the vascular medial calcification.
|
