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Analyses of bone fragility factors focused on bone chemical composition in chronic kidney disease

Research Project

Project/Area Number 23591223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionOita University of Nursing and Health Sciences

Principal Investigator

IWASAKI YOSHIKO  大分県立看護科学大学, 看護学部, 助教 (10360059)

Co-Investigator(Kenkyū-buntansha) KAZAMA Junichiro  新潟大学, 医歯学総合病院, 准教授 (10345499)
矢野 彰三  島根大学, 医学部, 准教授 (80403450)
Co-Investigator(Renkei-kenkyūsha) YANO Shozo  島根大学, 医学部, 准教授 (80403450)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords腎性骨症 / 骨脆弱性 / 骨組成変化 / ラマン分光法 / 骨折寄与因子 / 骨組成 / 慢性腎臓病 / 骨力学強度 / 尿毒症物質 / 骨質 / 腎機能低下
Research Abstract

Patients with chronic kidney disease (CKD) including dialysis patients have high risk of bone fracture. In order to elucidate the mechanisms underlying bone fragility in CKD patients we analyzed the bone material properties which indicate chemical composition. The bone samples from CKD represented lower storage modulus, which is one of mechanical properties, accompanied with the changes of bone chemical composition. These changes were influence on bone mechanical properties independent of bone mineral density, bone turnover, and hormones regulating bone metabolism. In addition, changes of bone chemical composition were improved by preventing accumulated uremic toxins in sera. These results suggest that controls for uremic conditions are possible new therapeutic approach for bone fragility.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (44 results)

All 2013 2012 2011

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (33 results) (of which Invited: 3 results) Book (4 results)

  • [Journal Article] Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Shimoda H, Fukagawa M
    • Journal Title

      Bone

      Volume: 57(2) Pages: 477-83

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38MAPK pathway2013

    • Author(s)
      Tanaka H, Iwasaki Y, Yamato H, Mori Y, Komaba H, Watanabe H, Maruyama T, Fukagawa M
    • Journal Title

      Bone

      Volume: 56(2) Pages: 347-54

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumulated uremic toxins attenuate bone mechanical properties in rats with chronic kidney disease.2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H. Shimoda H, Fukagawa M.
    • Journal Title

      Bone

      Volume: 57 Pages: 477-83

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p-Cresyl sulfate induces osteoblast dysfunction through activating JNK and p38MAPK pathway2013

    • Author(s)
      Tanaka H. Iwasaki Y, Yamato H, Mori Y, Komaba H, Watanabe H, Maruyama T, Fukagawa M.
    • Journal Title

      Bone

      Volume: 56 Pages: 347-54

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with pravastatin attenuates oxidative stress and protects osteoblast cell viability from indoxyl sulfate2011

    • Author(s)
      Iwasaki Y, Yamato H, Fukagawa M
    • Journal Title

      Ther Apher Dial

      Volume: 15(2) Pages: 151-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease2011

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
    • Journal Title

      Bone

      Volume: 48(6) Pages: 1260-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in chemical composition of cortical bone associated with bone fragility in rat model with chronic kidney disease.2011

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M.
    • Journal Title

      Bone

      Volume: 48 Pages: 1260-1267

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Altered material properties are responsible for bone fragility in rats with chronic kidney disease2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
    • Organizer
      Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2013-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性腎臓病における骨脆弱性には骨密度変化よりもむしろ材質特性変化が関与する2013

    • Author(s)
      岩崎香子、風間順一郎、松垣あいら、中野貴由、深川雅史
    • Organizer
      第15回日本骨粗鬆症学会
    • Place of Presentation
      大阪府
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] CKDと骨質2013

    • Author(s)
      岩崎香子
    • Organizer
      第15回日本骨粗鬆症学会シンポジウム6「CKD患者の骨」
    • Place of Presentation
      大阪府
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎機能低下における骨弾性率と骨密度との関連2013

    • Author(s)
      岩崎香子、桑原三恵子、菅野三喜男、風間順一郎
    • Organizer
      第58回日本透析医学会学術集会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Accumulated uremic toxins deteriorates bone material properties in rats with chronic kidney disease2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Matsugaki A, Nakano T, Yamato H, Fukagawa M
    • Organizer
      2^<nd> Joint Meeting of International Society of Bone Mineral Society and The Japanese Society of Bone and Mineral Research
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2013-05-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 尿毒症物質CMPFは骨芽細胞機能障害を惹起する2013

    • Author(s)
      岡藤梨歩、岩崎香子
    • Organizer
      第56回日本腎臓学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎臓と骨質2013

    • Author(s)
      岩崎香子
    • Organizer
      第56回日本腎臓学会ワークショップ1「腎臓とミネラル」
    • Place of Presentation
      東京
    • Year and Date
      2013-05-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Altered material properties are responsible for bone fragility in rats with chronic kidney disease.2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M.
    • Organizer
      American Society of Nephrology, Kidney Week 2013
    • Place of Presentation
      Atlanta, GA, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Accumulated uremic toxins deteriorates bone material properties in rats with chronic kidney disease.2013

    • Author(s)
      Iwasaki Y, Kazama JJ, Matsugaki A, Nakano T, Yamato H, Fukagawa M.
    • Organizer
      2nd Joint Meeting of International Society of Bone Mineral Society and The Japanese Society of Bone and Mineral Research.
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎機能低下における骨弾性率と骨密度との関連2013

    • Author(s)
      岩崎香子、桑原三恵子、菅野三喜男、風間順一郎
    • Organizer
      第58回 日本透析医学会学術集会・総会
    • Place of Presentation
      福岡市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性腎臓病における骨脆弱性には骨密度変化よりもむしろ材質特性変化が関与する2013

    • Author(s)
      岩崎香子、風間順一郎、松垣あいら、中野貴由、深川雅史
    • Organizer
      第15回日本骨粗鬆症学会学術集会
    • Place of Presentation
      大阪府
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腎臓と骨質2013

    • Author(s)
      岩崎香子
    • Organizer
      第56回日本腎臓学会ワークショップ1 腎臓とミネラル代謝
    • Place of Presentation
      東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CKDと骨質2013

    • Author(s)
      岩崎香子
    • Organizer
      第15回日本骨粗鬆症学会シンポジウム6 CKD患者の骨
    • Place of Presentation
      大阪府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] p-Cresyl sulfate deteriorates osteoblast function through Up-regulation MAPK cascade2012

    • Author(s)
      Tanaka H, Iwasaki Y, Mori T, Komaba H, Watanabe H, Yamato H, Maruyama T, Fuakgawa M
    • Organizer
      Kidney Week 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-11-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Accumulated indoxyl sulfate aggravate bone mechanical property with chronic kidney disease2012

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H. Fukagawa M .
    • Organizer
      Kidney Week 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性腎臓病における易骨折性には骨質因子の変化が関与する2012

    • Author(s)
      岩崎香子、松垣あいら、中野貴由、風間順一郎、大和英之、深川雅史
    • Organizer
      第14回日本骨粗鬆症学会学術集会
    • Place of Presentation
      新潟県
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性腎臓病での易骨折性骨質因子検討結果からの考察2012

    • Author(s)
      岩崎香子
    • Organizer
      第30回日本骨代謝学会シンポジム3「慢性腎臓病と骨ミネラル代謝」
    • Place of Presentation
      東京都
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性腎臓病における易骨折性の要因2012

    • Author(s)
      岩崎香子、松垣あいら、中野貴由、風間順一郎、大和英之、深川雅史
    • Organizer
      第32回日本骨形態計測学会
    • Place of Presentation
      大阪府
    • Year and Date
      2012-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] 慢性腎臓病における骨代謝への尿毒症物質p-Cresolとアルブミン濃度の関与2012

    • Author(s)
      田代沙知、岩崎香子
    • Organizer
      第55回日本腎臓学会学術集会
    • Place of Presentation
      神奈川県
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 尿毒症物質の血中蓄積は骨脆弱性に関与する2012

    • Author(s)
      岩崎香子、風間順一郎、大和英之、深川雅史
    • Organizer
      第55回日本腎臓学会学術集会
    • Place of Presentation
      神奈川県
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Kidney dysfunction exacerbate bone strength through changing bone material composition2012

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H. Fukagawa M
    • Organizer
      International Society of Nephrology Nexus
    • Place of Presentation
      Copenhagen、Denmark
    • Related Report
      2013 Final Research Report
  • [Presentation] Kidney dysfunction exacerbates bone strength through changing bone material composition.2012

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
    • Organizer
      International Society of Nephrology Nexus 2012
    • Place of Presentation
      Copenhagen (Danmark)
    • Related Report
      2012 Research-status Report
  • [Presentation] Accumulated indoxyl sulfate aggravate bone mechanical property with chronic kidney disease2012

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M
    • Organizer
      American Society of Nephrology Kidney Week 2012
    • Place of Presentation
      San Diego (USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 尿毒症物質の血中蓄積は骨脆弱性に関与する2012

    • Author(s)
      岩崎香子、風間順一郎、大和英之、深川雅史
    • Organizer
      第55回日本腎臓学会学術集会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性腎臓病における易骨折性には骨質因子の変化が関与する2012

    • Author(s)
      岩崎香子、松垣あいら、中野貴由、風間順一郎、大和英之、深川雅史
    • Organizer
      第14回日本骨粗鬆症学会学術集会
    • Place of Presentation
      新潟県新潟市
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性腎臓病での易骨折性-骨質因子検討結果からの考察-2012

    • Author(s)
      岩崎香子
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京都千代田区
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 慢性腎臓病に伴う低代謝回転骨の易骨折性には骨組成変化が関与する2011

    • Author(s)
      岩崎香子、風間順一郎、大和英之、深川雅史
    • Organizer
      第13回日本骨粗鬆症学会
    • Place of Presentation
      兵庫県
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] 高ホモシステイン血症による骨芽細胞機能低下はNMDA受容体を介する2011

    • Author(s)
      河野歩美、大和英之、岩崎香子
    • Organizer
      第54回日本腎臓学会学術集会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-06-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎不全動物における骨中メーラード反応生成物蓄積と骨弾性率低下との関連2011

    • Author(s)
      岩崎香子、大和英之、深川雅史
    • Organizer
      第31回日本骨形態計測学会
    • Place of Presentation
      岐阜県
    • Year and Date
      2011-05-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes of chemical composition affect bone mechanical property in early chronic kidney disease2011

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H. Fukagawa M
    • Organizer
      International Society of Nephrology 7^<th>International Congress on uremic research and toxicity
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2011-05-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes of chemical composition affect bone mechanical property in early chronic kidney disease.2011

    • Author(s)
      Iwasaki Y, Kazama JJ, Yamato H, Fukagawa M.
    • Organizer
      International Society of Nephrology-7th International Congress on uremic research and toxicity.
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Research-status Report
  • [Presentation] 腎不全動物における骨中メーラード反応生成物蓄積と骨弾性率低下との関連2011

    • Author(s)
      岩崎香子、風間順一郎、大和英之、深川雅史
    • Organizer
      第31回日本骨形態計測学会
    • Place of Presentation
      岐阜県岐阜市
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性腎臓病に伴う低代謝回転骨の易骨折性には骨組成変化が関与する2011

    • Author(s)
      岩崎香子、風間順一郎、大和英之、深川雅史
    • Organizer
      第13回日本骨粗鬆症学会
    • Place of Presentation
      兵庫県神戸市
    • Related Report
      2011 Research-status Report
  • [Book] "ガイドラインサポートハンドブック慢性腎臓病に伴う骨・ミネラル代謝異常(CKD-MBD)改訂版"最新の話題と問題点CKD-MBDと骨質2013

    • Author(s)
      岩崎香子、大和英之
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Final Research Report
  • [Book] "CKD-MBDハンドブック2nd edition"CKD-MBDと骨質2013

    • Author(s)
      岩崎香子、大和英之
    • Publisher
      日本メディカルセンター
    • Related Report
      2013 Final Research Report
  • [Book] 慢性腎臓病に伴う骨・ミネラル代謝異常(CKD-MBD)改定版2013

    • Author(s)
      岩崎香子、大和英之
    • Total Pages
      334
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] CKD-MBDハンドブック2nd edition2013

    • Author(s)
      岩崎香子、大和英之
    • Total Pages
      325
    • Publisher
      日本メディカルセンター
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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