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Gliogenesis and angiogenesis: possible regenerative targets in spinal cord of a transgenic model of ALS

Research Project

Project/Area Number 23591229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionTohoku University

Principal Investigator

WARITA Hitoshi  東北大学, 医学(系)研究科(研究院), 助教 (30400245)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords臨床神経分子遺伝学 / 神経再生 / 運動ニューロン / 神経変性 / 動物モデル
Research Abstract

Amyotrophic lateral sclerosis (ALS) is an adult-onset devastating disease characterized by degeneration of motor neurons. Although neural stem/progenitor cells reside around the central canal of adult spinal cord, neurogenesis does not occur under physiological condition. Previous reports showed diverse results on neurogenesis in ALS model mice.
In this study, we examined a possible regenerative response in an ALS rat model. After onset of the disease, multiple immunohistochemistry with selective cell markers revealed a significant increase of neural progenitor cells around the central canal with prominent proliferation of glial cells throughout parenchyma. As compared with control, intrathecal infusion of an angiogenesis-modulating agent for 14 days significantly reduced gliogenesis, increased number of neuroblastic cells, and partial neuroprotection in the spinal cord of ALS rats.
Therefore, modulating angiogenesis or/and gliogenesis may be a novel regenerative target in ALS.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (26 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (13 results) (of which Invited: 2 results) Book (2 results) Remarks (4 results)

  • [Journal Article] ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis2013

    • Author(s)
      Tanaka H, Shimazawa M, Takata M, Kaneko H, Tsuruma K, Ikeda T, Warita H, Aoki M, Yamada M, Takahashi H, Hozumi I, Minatsu H, Inuzuka T, Hara H
    • Journal Title

      J Neurol

      Volume: 260(7) Pages: 1782-1797

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経変性と機能保持・回復の神経科学的基盤2013

    • Author(s)
      割田仁
    • Journal Title

      神経治療学

      Volume: 30(6) Pages: 718-721

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Exome sequencing identifies a novel TTN mutation in a family with hereditary myopathy with early respiratory failure2013

    • Author(s)
      Izumi R, Niihori T, Aoki Y, Suzuki N, Kato M, Warita H, Takahashi T, Tateyama M, Nagashima T, Funayama R, Abe K, Nakayama K, Aoki M, Matsubara Y
    • Journal Title

      J Hum Genet

      Volume: 58(5) Issue: 5 Pages: 259-66

    • DOI

      10.1038/jhg.2013.9

    • NAID

      10031177220

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.2013

    • Author(s)
      Tanaka H.. Shimazawa M., Takata M., Kaneko H., Tsuruma K., Ikeda T., Warita H., Aoki M., Yamada M., Takahashi H., Hozumi I., Minatsu H., Inuzuka T. and Hara H.
    • Journal Title

      Journal of Neurology

      Volume: (Epub ahead of print) Issue: 7 Pages: 1782-1797

    • DOI

      10.1007/s00415-013-6877-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats2012

    • Author(s)
      Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K
    • Journal Title

      Glia

      Volume: 60(5) Pages: 782-793

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ALSに対する再生医療の開発2012

    • Author(s)
      割田仁,青木正志
    • Journal Title

      脳21

      Volume: 15(1) Pages: 57-61

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Involvement of activated microglia in increased vulnerability of motoneurons after facial nerve avulsion in presymptomatic amyotrophic lateral sclerosis model rats2012

    • Author(s)
      Sanagi T, Nakamura Y, Suzuki E, Uchino S, Aoki M, Warita H, Itoyama Y, Kohsaka S, Ohsawa K.
    • Journal Title

      GLIA

      Volume: 60 Issue: 5 Pages: 782

    • DOI

      10.1002/glia.22308

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 変異SOD1による神経変性モデル脊髄における微小血管壁細胞2013

    • Author(s)
      割田仁、水野秀紀、加藤昌昭、鈴木直輝、青木正志
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症モデルラット微小血管の壁細胞を標的とした運動ニューロン保護2013

    • Author(s)
      割田仁、水野秀紀、加藤昌昭、鈴木直輝、青木正志
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 東北大学における家族性ALS遺伝子検査の検討2013

    • Author(s)
      加藤昌昭、割田仁、井泉瑠美子、島倉奈緒子、安藤里紗、鈴木直輝、青木正志
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 変異SOD1によるラット神経変性モデル脊髄における微小血管壁細胞2013

    • Author(s)
      割田 仁,水野秀紀,加藤昌昭,鈴木直輝,青木正志
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 運動ニューロン疾患モデル脊髄における増殖性グリア細胞の形質変化2012

    • Author(s)
      割田仁、水野秀紀、加藤昌昭、鈴木直輝、青木正志
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Phenotypically transformed glial cells accumulate in adult spinal cords of transgenic rats with motor neuron degeneration2012

    • Author(s)
      Warita H, Mizuno H, Suzuki N, Itoyama Y, Aoki M
    • Organizer
      10th Annual Meeting of the International Society for Stem Cell Research
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] アカデミア発の創薬:ALSに対するHGF2012

    • Author(s)
      割田仁
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 筋萎縮性側索硬化症モデルラット新生グリア細胞が形成する脊髄微小環境2012

    • Author(s)
      割田仁、加藤昌昭、鈴木直輝、水野秀紀、青木正志
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Phenotypically transformed glial cells accumulate in adult spinal cords of transgenic rats with motor neuron degeneration.2012

    • Author(s)
      Warita H, Mizuno H, Suzuki N, Itoyama Y, Aoki M
    • Organizer
      10th Annual Meeting of the International Society for Stem Cell Research
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Research-status Report
  • [Presentation] アカデミア発の創薬: ALSに対するHGF2012

    • Author(s)
      割田 仁
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Adult skeletal myogenesis in a rat model of amyotrophic lateral sclerosis2011

    • Author(s)
      Warita H, Mizuno H, Suzuki N, Itoyama Y, Aoki M
    • Organizer
      9th Annual Meeting of the International Society for Stem Cell Research
    • Place of Presentation
      トロント、カナダ
    • Related Report
      2013 Final Research Report
  • [Presentation] 筋萎縮性側索硬化症モデルラットにおける骨格筋再生2011

    • Author(s)
      割田仁、水野秀紀、鈴木直輝、糸山泰人、青木正志
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Adult Skeletal Myogenesis in a Rat Model of Amyotrophic Lateral Sclerosis.2011

    • Author(s)
      Warita H, Mizuno H, Suzuki N, Itoyama Y, Aoki M
    • Organizer
      9th Annual Meeting of the International Society for Stem Cell Research
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Research-status Report
  • [Book] アクチュアル脳・神経疾患の臨床小脳と運動失調小脳はなにをしているのか「皮質性小脳萎縮症」2013

    • Author(s)
      割田仁、青木正志(総編集辻省次、専門編集西澤正豊)
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] アクチュアル脳・神経疾患の臨床 小脳と運動失調 小脳はなにをしているのか 「皮質性小脳萎縮症」2013

    • Author(s)
      割田 仁, 青木正志 (総編集 辻 省次,専門編集 西澤正豊)
    • Publisher
      中山書店
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.neurol.med.tohoku.ac.jp/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 東北大学神経内科

    • URL

      http://www.neurol.med.tohoku.ac.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東北大学神経内科

    • URL

      http://www.neurol.med.tohoku.ac.jp/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.neurol.med.tohoku.ac.jp/index.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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