| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Amyotrophic lateral sclerosis (ALS) is an adult-onset devastating disease characterized by degeneration of motor neurons. Although neural stem/progenitor cells reside around the central canal of adult spinal cord, neurogenesis does not occur under physiological condition. Previous reports showed diverse results on neurogenesis in ALS model mice.
In this study, we examined a possible regenerative response in an ALS rat model. After onset of the disease, multiple immunohistochemistry with selective cell markers revealed a significant increase of neural progenitor cells around the central canal with prominent proliferation of glial cells throughout parenchyma. As compared with control, intrathecal infusion of an angiogenesis-modulating agent for 14 days significantly reduced gliogenesis, increased number of neuroblastic cells, and partial neuroprotection in the spinal cord of ALS rats.
Therefore, modulating angiogenesis or/and gliogenesis may be a novel regenerative target in ALS.
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