| Project/Area Number |
23591231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Gunma University |
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Principal Investigator |
IKEDA MASAKI 群馬大学, 医学部附属病院, 講師 (50222899)
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Koichi 群馬大学, 大学院医学系研究科, 教授 (00124652)
YAMAZAKI Tsuneo 群馬大学, 大学院保健学研究科, 教授 (80200658)
FUJITA Yukio 群馬大学, 大学院医学系研究科, 講師 (70420172)
MAKIOKA Kouki 群馬大学, 医学部附属病院, 助教 (10420176)
FURUTA Natsumi 群馬大学, 医学部附属病院, 助教 (80625583)
平柳 公利 群馬大学, 医学部附属病院, 助教 (20701395)
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| Co-Investigator(Renkei-kenkyūsha) |
SHOJI Mikio 弘前大学, 大学院医学研究科 (60171021)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | プレセニリン / タウ / 脳脊髄液 / アルツハイマー病 / 遺伝子変異 / アミロイドβ / 髄液 / リン酸化タウ / 神経細胞死 |
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| Research Abstract |
We confirmed 6 AD different PS1 mutations (T99A, H131R, H163R, M233L, L219R, V272A) in 6 independent Japansese FAD families. They showed slight elevation of CSF ptau (199, 181), reduction of Ab1-42, Ab1-40 and Ab1-38. While CSF Ab1-42 remained same level, CSF Ab1-40 and Ab1-38 gradually decreased. This may suggest active sites of gamma-secretase are different between sporadic AD and PS1 mutatnt AD patients, and Ab processing might be changing in aging of PS1 mutant AD.
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