Analysis for Detection of Immunogenic Site on Aquaporin-4 in Neuromyelitis Optica
| Project/Area Number |
23591232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
MASAHIRO Mori 千葉大学, 医学部附属病院, 講師 (70345023)
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| Co-Investigator(Kenkyū-buntansha) |
HIWASA Takaki 千葉大学, 医学研究院, 准教授 (30260251)
KUNIMATSU Toshimi 名古屋女子大学, 家政学部, 教授 (70145746)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 神経免疫疾患 / 視神経脊髄炎 / 多発性硬化症 / 抗アクアポリン４抗体 / aquaporin-4 / 抗体 |
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| Research Abstract |
We performed anlysis using arrays consisting synthesized 156 peptides using peptide library data from entire human aquaporin-4 (AQP4) 'isoform a' sequences on a cellulose membrane. These peptides were reacted with serum samples obtained from 22 individuals with neuromyelitis optic (NMO), and 8 disease/normal controls. As a result, we can detect the immunogenic site on AQP4 that is recognized by the anti-AQP4 antibody in NMO patients. A peptides derived from an extracellular loop A of AQP4 may be a central immunogenic site on AQP4 in NMO. We have presented these resutls in domestic and international conferences.
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Report
(4 results)
Research Products
(23 results)
