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Establishment of early diagnosis method and new non-invasive therapy for transthyretin amyloidosis

Research Project

Project/Area Number 23591237
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionShinshu University

Principal Investigator

SEKIJIMA Yoshiki  信州大学, 医学部, 准教授 (60322715)

Co-Investigator(Kenkyū-buntansha) TOJO Kana  信州大学, 医学部附属病院, 助教(特定雇用) (10467178)
Co-Investigator(Renkei-kenkyūsha) MORITA Hiroshi  信州大学, 医学部附属病院, 准教授 (10262718)
KOYAMA Jun  信州大学, 医学系研究科, 准教授 (10303463)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアミロイド / トランスサイレチン / 老化 / 蛋白質 / 早期診断 / 新規治療 / アミロイドーシス / 家族性アミロイドポリニューロパチー / 老人性全身性アミロイドーシス
Research Abstract

We showed that abdominal fat biopsy is the most sensitive early diagnosis method for familial amyloid polyneuropathy (FAP). We also showed that endomyocardial biopsy or gastroduodenal biopsy is the most sensitive early diagnosis method for senile systemic amyloidosis (SSA). Surgical skin biopsy including the deep subcutaneous fat pad is a useful alternative histopathological diagnosis tool for SSA when patient is in poor condition.
With regard to treatment, we demonstrated that diflunisal inhibit polyneuropathy progression and preserve quality of life in patients with FAP in its 2-year randomized controlled trial. We also analyzed the tolerance and efficacy of long-term diflunisal administration in FAP patients and showed that clinical effects of diflunisal are sustained after two years of treatment.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (85 results)

All 2014 2013 2012 2011

All Journal Article (18 results) (of which Peer Reviewed: 12 results) Presentation (59 results) (of which Invited: 12 results) Book (8 results)

  • [Journal Article] Follow-up nationwide survey on predictive genetic testing for late-onset hereditary neurological diseases in Japan2013

    • Author(s)
      Tanaka K, Sekijima Y, Yoshida K, Tamai M, Kosho T, Sakurai A, Wakui K, Ikeda SI, Fukushima Y
    • Journal Title

      J Hum Genet

      Volume: 58 Issue: 8 Pages: 560-563

    • DOI

      10.1038/jhg.2013.34

    • NAID

      10031195287

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High prevalence of ATTR amyloidosis in endomyocardial biopsy-proven cardiac amyloidosis patients2013

    • Author(s)
      Nakagawa M, Sekijima Y, Tojo K, Ikeda SI
    • Journal Title

      Amyloid

      Volume: 20 Issue: 2 Pages: 138-40

    • DOI

      10.3109/13506129.2013.790809

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Steady turnover of amyloid fibril proteins in gastric mucosa after liver transplantation in familial amyloid polyneuropathy2013

    • Author(s)
      Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Kametani F, Ikeda S
    • Journal Title

      Amyloid

      Volume: 20 Issue: 3 Pages: 156-163

    • DOI

      10.3109/13506129.2013.807790

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bullous formation in a patient with familial amyloid polyneuropathy type I2013

    • Author(s)
      Kobayashi A, Uhara H, Kido K, Sekijima Y, Tojo K, Ikeda S, Okuyama R
    • Journal Title

      Int J Dermatol

      Volume: 52 Issue: 11 Pages: 1398-400

    • DOI

      10.1111/j.1365-4632.2011.05146.x

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial2013

    • Author(s)
      Berk JL, Suhr OB, Obici L, Sekijima Y, Zeldenrust SR, Yamashita T, Heneghan MA, Gorevic PD, Litchy WJ, Wiesman JF, Nordh E, Corato M, Lozza A, Cortese A, Robinson-Papp J, Colton T, Rybin DV, Bisbee AB, Ando Y, Ikeda S, Seldin DC, Merlini G, Skinner M, Kelly JW, Dyck PJ; Diflunisal Trial Consortium
    • Journal Title

      JAMA

      Volume: 310 Issue: 24 Pages: 2658-2667

    • DOI

      10.1001/jama.2013.283815

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチーに対する新規治療法の開発と臨床応用2013

    • Author(s)
      関島良樹
    • Journal Title

      日本遺伝カウンセリング学会誌

      Volume: 34 Pages: 31-37

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 家族性アミロイドポリニューロパチー2013

    • Author(s)
      関島良樹,池田修一
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 515-520

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 信州大学医学部附属病院遺伝子診療部における遺伝性神経筋疾患の発症前診断の現状2013

    • Author(s)
      田中敬子,関島良樹,吉田邦広,水内麻子,山下浩美,玉井真理子,池田修一,福嶋義光
    • Journal Title

      臨床神経学

      Volume: 53 Pages: 196-204

    • NAID

      40019608487

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two Siblings Diagnosed to Have Transthyretin-related Familial Amyloid Cardiomyopathy Around the Same Time at Different Hospitals2012

    • Author(s)
      Miyamura M, Terasaki F, Ishibashi K, Shimazaki C, Kimura F, Kuwabara H, Tsuji M, Shibayama Y, Sekijima Y, Tojo K, Ishizaka N
    • Journal Title

      Intern Med

      Volume: 51 Pages: 465-9

    • NAID

      130002061902

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Arterial thromboembolism in senile systemic amyloidosis: report of two cases2012

    • Author(s)
      Nakagawa M, Tojo K, Sekijima Y, Yamazaki KH, Ikeda S.
    • Journal Title

      Amyloid

      Volume: 19 Issue: 2 Pages: 118-121

    • DOI

      10.3109/13506129.2012.685131

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Diflunisal Trial: study accrual and drug tolerance.2012

    • Author(s)
      Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L
    • Journal Title

      Amyloid

      Volume: Suppl 1 Issue: sup1 Pages: 37-38

    • DOI

      10.3109/13506129.2012.678509

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心アミロイドーシスの診断と治療2012

    • Author(s)
      関島良樹
    • Journal Title

      循環器内科

      Volume: 71 Pages: 526-533

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Two Siblings Diagnosed to Have Transthyretin-related Familial Amyloid Cardiomyopathy Around the Same Time at Different Hospitals2012

    • Author(s)
      Miyamura M, Terasaki F, Ishibashi K, Shimazaki C, Kimura F, Kuwabara H, Tsuji M, Shibayama Y, Sekijima Y, Tojo K, Ishizaka N.
    • Journal Title

      Internal Medicine

      Volume: 51 Issue: 5 Pages: 465-469

    • DOI

      10.2169/internalmedicine.51.6369

    • NAID

      130002061902

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチー2012

    • Author(s)
      関島良樹,池田修一
    • Journal Title

      新しい診断と治療のABC

      Volume: 75 Pages: 186-195

    • Related Report
      2012 Research-status Report
  • [Journal Article] High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome : a common cause of carpal tunnel syndrome in the elderly2011

    • Author(s)
      Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda SI
    • Journal Title

      Hum Pathol

      Volume: 42 Issue: 11 Pages: 1785-91

    • DOI

      10.1016/j.humpath.2011.03.004

    • NAID

      120007107381

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic value of abdominal wall fat pad biopsy in senile systemic amyloidosis2011

    • Author(s)
      Ikeda SI, Sekijima Y, Tojo K, Koyama J
    • Journal Title

      Amyloid

      Volume: 18 Issue: 4 Pages: 211-5

    • DOI

      10.3109/13506129.2011.623199

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 家族性アミロイドポリニューロパチーの新しい治療戦略2011

    • Author(s)
      関島良樹
    • Journal Title

      神経内科

      Volume: 74 Pages: 360-366

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] 非家族性全身性アミロイドーシスの疫学と臨床2011

    • Author(s)
      関島良樹
    • Journal Title

      臨床神経

      Volume: 51 Pages: 1130-1133

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチーの基礎から治療へ2014

    • Author(s)
      関島良樹
    • Organizer
      東京都医学研セミナー
    • Place of Presentation
      東京
    • Year and Date
      2014-02-21
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 家族性アミロイドーシスの病態に基づいた新規治療法の開発と遺伝カウンセリング2014

    • Author(s)
      関島良樹
    • Organizer
      第100回千葉大学遺伝子診療部セミナー
    • Place of Presentation
      千葉
    • Year and Date
      2014-02-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 家族性アミロイドーシスの病態に基づいた新規治療法の開発と遺伝カウンセリング2014

    • Author(s)
      関島良樹
    • Organizer
      第100回千葉大学遺伝子診療部セミナー
    • Place of Presentation
      千葉大学医学部附属病院(千葉県千葉市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 家族性アミロイドポリニューロパチーの基礎から治療へ2014

    • Author(s)
      関島良樹
    • Organizer
      東京都医学研セミナー
    • Place of Presentation
      (公財)東京都医学総合研究所(東京都世田谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 心筋生検組織のアミロイド分析からみた心アミロイドーシスの基礎疾患の検討2013

    • Author(s)
      関島良樹,中川道隆,東城加奈,池田修一
    • Organizer
      第1回日本アミロイド―シス研究会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経疾患の治療に関する最近の話題と今後の展望2013

    • Author(s)
      関島良樹
    • Organizer
      第48回信越支部主催生涯教育講演会
    • Place of Presentation
      長野
    • Year and Date
      2013-06-09
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 小胞体関連分解によるトランスサイレチンアミロイド―シスに対する自己防御機構と病態に基づいた新規治療法の開発2013

    • Author(s)
      関島良樹
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Safety and efficacy of long-term diflunisal administration in late-onset ATTR Val30Met FAP2013

    • Author(s)
      Sekijima Y, Tojo K, Morita H, Koyama J, Koike H, Sobue G, Ikeda S
    • Organizer
      IX^<th> International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] Steady amyloid turn-over after liver transplantation in FAP patients2013

    • Author(s)
      Yazaki M, Tsuchiya-Suzuki A, Sekijima Y, Kametani F, Ikeda S
    • Organizer
      IX^<th> International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢発症ATTR Val30Met FAP患者の末梢神経機能に対するジフルニサルの有効性の検討2013

    • Author(s)
      関島良樹,東城加奈,森田洋,小池春樹,祖父江元,池田修一
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経疾患の治療に関する最近の話題と今後の展望2013

    • Author(s)
      関島良樹
    • Organizer
      第48回 信越支部主催生涯教育講演会
    • Place of Presentation
      長野市若里市民文化ホール(長野県長野市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小胞体関連分解によるトランスサイレチンアミロイド―シスに対する自己防御機構と病態に基づいた新規治療法の開発2013

    • Author(s)
      関島良樹
    • Organizer
      第8回臨床ストレス応答学会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 高齢発症ATTR Val30Met FAP患者の末梢神経機能に対するジフルニサルの有効性の検討2013

    • Author(s)
      関島良樹,東城加奈,森田洋,小池春樹,祖父江元,池田修一
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心筋生検組織のアミロイド分析からみた心アミロイド―シスの基礎疾患の検討2013

    • Author(s)
      関島良樹,中川道隆,東城加奈,池田修一
    • Organizer
      第1回日本アミロイド―シス研究会学術大会
    • Place of Presentation
      KKRホテル東京(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝性・先天性疾患に対する横断的診療連携体制の構築・信州大学医学部附属病院遺伝子診療部の取り組み2013

    • Author(s)
      石河真澄、古庄知己、黄瀬恵美子、中村勝哉、山嵜雅則、玉井真理子、山下浩美、高津亜希子、菊池範彦、大平哲史、金井誠、丸山孝子、河村理恵、涌井敬子、関島良樹、櫻井晃洋、福嶋義光
    • Organizer
      第58回日本人類遺伝学会
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Steady amyloid turn-over after liver transplantation in FAP patients2013

    • Author(s)
      Yazaki M, Tsuchiya-Suzuki A, Sekijima Y, Kametani F, Ikeda S
    • Organizer
      IXth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Federal University of Rio deJaneiro(Rio de Janeiro,Brazil)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Safety and efficacy of long-term diflunisal administration in late-onset ATTR Val30Met FAP2013

    • Author(s)
      Sekijima Y, Tojo K, Morita H, Koyama J, Koike H, Sobue G, Ikeda S
    • Organizer
      IXth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Federal University of Rio deJaneiro(Rio de Janeiro,Brazil)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 手根菅症候群で発症したATTR Tyr114His型家族性アミロイドポリニューロパチーの1例2012

    • Author(s)
      永松清志郎,田澤浩一,関島良樹,池田修一
    • Organizer
      第130回日本内科学会信越地方会
    • Place of Presentation
      新潟
    • Year and Date
      2012-06-02
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 本邦における遺伝性神経筋疾患に対する発症前診断の現状と課題2012

    • Author(s)
      関島良樹,田中敬子,吉田邦広,福嶋義光
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチー(FAP)に対する新規治療法の開発と臨床応用2012

    • Author(s)
      関島良樹
    • Organizer
      第36回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 当院における遺伝性神経疾患の発症前診断の現状2012

    • Author(s)
      関島良樹,田中敬子,吉田邦広,水内麻子,山下浩美,玉井眞理子,福嶋義光,池田修一
    • Organizer
      第36回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 全国の医療機関における遺伝性神経筋疾患に対する発症前診断の現状2012

    • Author(s)
      田中敬子,関島良樹,吉田邦広,福嶋義光
    • Organizer
      第36回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 当院における遺伝性神経疾患の発症前診断の現状2012

    • Author(s)
      関島良樹,田中敬子,吉田邦広,水内麻子,山下浩美,玉井眞理子,福嶋義光,池田修一
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチー(FAP)患者の発症年齢の推移に関する検討2012

    • Author(s)
      池田修一,関島良樹,東城加奈,鈴木彩子,矢崎正英
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] The distribution of age at onset of ATTRVal30Met FAP in Japan2012

    • Author(s)
      Sekijima Y, Tojo K, Tsuchiya-Suzaki A, Yazaki M, Ikeda S
    • Organizer
      XIII^<th> International Symposium on Amyloidosis
    • Place of Presentation
      Groningen, Netherland
    • Related Report
      2013 Final Research Report
  • [Presentation] Neurological manifestations of senile systemic amyloidosis2012

    • Author(s)
      Ikeda S, Sekijima Y, Tojo K, Nakagawa M, Morita, H, Koyama J
    • Organizer
      XIII^<th> International Symposium on Amyloidosis
    • Place of Presentation
      Groningen, Netherland
    • Related Report
      2013 Final Research Report
  • [Presentation] The Diflunisal Trial : Demographics,baseline neurologic sraging, and adverse events2012

    • Author(s)
      Berk JL, Obici L, Zeldenrust SR, Sekijima Y, Yamashita T, Heneghan M, Ikeda S, Ando Y,Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Suhr OR, Familial Amyloidosis Consortium
    • Organizer
      XIII^<th> International Symposium on Amyloidosis
    • Place of Presentation
      Groningen, Netherland
    • Related Report
      2013 Final Research Report
  • [Presentation] Neurological manifestations of senile systemic amyloidosis2012

    • Author(s)
      Ikeda S, Sekijima Y, Tojo K, Nakagawa M, Morita H, Koyama J
    • Organizer
      XIIIthe International Symposium on Amyloidosis
    • Place of Presentation
      Groningen
    • Related Report
      2012 Research-status Report
  • [Presentation] The distribution of age at onset of ATTRVal30Met FAP in Japan2012

    • Author(s)
      Sekijima Y, Tojo K, Tsuchiya-Suzaki A, Yazaki M, Ikeda S
    • Organizer
      XIIIthe International Symposium on Amyloidosis
    • Place of Presentation
      Groningen
    • Related Report
      2012 Research-status Report
  • [Presentation] The Diflunisal Trial:Demographics,baseline neurologic sraging, and adverse events2012

    • Author(s)
      Berk JL, Obici L, Zeldenrust SR, Sekijima Y, Yamashita T, Heneghan M, Ikeda S, Ando Y,Gorevic P, Merlini G, Kelly JW, Skinner M Bisbee AB, Dyck PJ, Suhr OR, Familial Amyloidosis Consortium
    • Organizer
      XIIIthe International Symposium on Amyloidosis
    • Place of Presentation
      Groningen
    • Related Report
      2012 Research-status Report
  • [Presentation] 家族性アミロイドポリニューロパチー(FAP) に対する新規治療法の開発と臨床応用2012

    • Author(s)
      関島良樹
    • Organizer
      第36回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      松本
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Safety and efficacy of long-term administration of diflunisal to familial amyloid polyneuropathy patients2011

    • Author(s)
      Sekijima Y, Tojo K, Morita H, Koyama J, SuzukiA, Yazaki M, Ikeda S
    • Organizer
      VIII^<th> International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] High prevalence of wild-type TTR amyloid deposition in patients with idiopathic carpal tunnel syndrome2011

    • Author(s)
      Sekijima Y, Uchiyama S, Tojo K, Sano K, ShimizuY, Imaeda T, Hoshii Y, Kato H, Ikeda S
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] Systemic embolism in senile systemic amyloidosis : report of 2 cases2011

    • Author(s)
      Nakagawa M, Tojo K, Sekijima Y, Ikeda S, Yamazaki K. . VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] The contribution of wild-type TTR to deposited amyloid onto gastroduodenum of FAP patients : the effect of liver transplantation2011

    • Author(s)
      Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Takei Y, Ikeda S, Kametami F
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] A follow-up study of 48 FAP patients who underwent liver transplantation2011

    • Author(s)
      Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Takei Y, Ikegami T, Miyagawa S, Matsunami H, Ikeda S
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] The Diflunisal Trial : Study accrual and drug tolerance2011

    • Author(s)
      Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S-I, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L, et al
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] The range of onset in ATTRVal30Met FAP and theclinical picture of the patients with this disease who started after the age of 702011

    • Author(s)
      Ikeda S, Tojo K, Sekijima Y, Yazaki M
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      Kumamoto
    • Related Report
      2013 Final Research Report
  • [Presentation] 特発性手根管症候群患者における野生型トランスサイレチンアミロイド沈着の頻度に関する研究2011

    • Author(s)
      関島良樹,内山茂晴,東城加奈,佐野健司,清水雄策,今枝敏彦,加藤博之,池田修一
    • Organizer
      第22回日本末梢神経学会学術集会
    • Place of Presentation
      那覇
    • Related Report
      2013 Final Research Report
  • [Presentation] 非家族性アミロイドーシスの臨床と疫学2011

    • Author(s)
      関島良樹
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Diflunisalを用いた家族性アミロイドポリニューロパチーに対する新規薬物療法の開発2011

    • Author(s)
      関島良樹,東城加奈,森田洋,鈴木彩子,矢崎正英,池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 70歳以後に診断されたFAP-ATTRVal30Met患者の臨床像の検討2011

    • Author(s)
      池田修一,東城加奈,関島良樹,鈴木彩子,矢崎正英
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 老人性全身性アミロイドーシスの早期診断における両側手根管症候群の有用性2011

    • Author(s)
      江澤直樹,東城加奈,関島良樹,池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝移植後FAP患者における組織沈着アミロイドのturn-overについて2011

    • Author(s)
      鈴木彩子,矢崎正英,関島良樹,亀谷富由樹,池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] High pevalence of wild-type TTR deposition in patients with idiopathic carpal tunnel syndrome : A common cause of carpal tunnel syndrome in the elderly2011

    • Author(s)
      Sekijima Y, Uchiyama S, Tojo K, Sano K, ShimizuY, Imaeda T, Kato H, Ikeda S
    • Organizer
      The 63rd Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Honolulu
    • Related Report
      2013 Final Research Report
  • [Presentation] Safety and efficacy of long-term administration of diflunisal to familial amyloid polyneuropathy patients2011

    • Author(s)
      Sekijima Y, Tojo K, Morita H, Koyama J, Suzuki A, Yazaki M, Ikeda S
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy(招待講演)
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] High prevalence of wild-type TTR amyloid deposition in patients with idiopathic carpal tunnel syndrome2011

    • Author(s)
      Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda S
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] Systemic embolism in senile systemic amyloidosis:report of 2 cases2011

    • Author(s)
      Nakagawa M, Tojo K, Sekijima Y, Ikeda S, Yamazaki K
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] The contribution of wild-type TTR to deposited amyloid onto gastroduodenum of FAP patients:the effect of liver transplantation2011

    • Author(s)
      Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Takei Y, Ikeda S, Kametami F
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] A follow-up study of 48 FAP patients who underwent liver transplantation2011

    • Author(s)
      Tsuchiya-Suzuki A, Yazaki M, Sekijima Y, Takei Y, Ikegami T, Miyagawa S, Matsunami H, Ikeda S
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] The Diflunisal Trial: Study accrual and drug tolerance2011

    • Author(s)
      Berk JL, Suhr OB, Sekijima Y, Yamashita T, Heneghan M, Zeldenrust SR, Ando Y, Ikeda S-I, Gorevic P, Merlini G, Kelly JW, Skinner M, Bisbee AB, Dyck PJ, Obici L, et al
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy(招待講演)
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Presentation] High pevalence of wild-type TTR deposition in patients with idiopathic carpal tunnel syndrome: A common cause of carpal tunnel syndrome in the elderly2011

    • Author(s)
      Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Kato H, Ikeda S
    • Organizer
      The 63rd Annual Meeting of the American Academy of Neurology
    • Place of Presentation
      Hawaii Convention Center(Honolulu)
    • Related Report
      2011 Research-status Report
  • [Presentation] 非家族性アミロイドーシスの臨床と疫学2011

    • Author(s)
      関島良樹
    • Organizer
      第52回日本神経学会学術大会(招待講演)
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Diflunisalを用いた家族性アミロイドポリニューロパチーに対する新規薬物療法の開発2011

    • Author(s)
      関島良樹、東城加奈、森田洋、鈴木彩子、矢崎正英、池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 70歳以後に診断されたFAP-ATTRVal30Met患者の臨床像の検討2011

    • Author(s)
      池田修一、東城加奈、関島良樹、鈴木彩子、矢崎正英
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 老人性全身性アミロイドーシスの早期診断における両側手根管症候群の有用性2011

    • Author(s)
      江澤直樹、東城加奈、関島良樹、池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝移植後FAP患者における組織沈着アミロイドのturn-overについて2011

    • Author(s)
      鈴木彩子、矢崎正英、関島良樹、亀谷富由樹、池田修一
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Research-status Report
  • [Presentation] 特発性手根管症候群患者における野生型トランスサイレチンアミロイド沈着の頻度に関する研究2011

    • Author(s)
      関島良樹、内山茂晴、東城加奈、佐野健司、清水雄策、今枝敏彦、加藤博之、池田修一
    • Organizer
      日本末梢神経学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県那覇)
    • Related Report
      2011 Research-status Report
  • [Presentation] The range of onset in ATTRVal30Met FAP and theclinical picture of the patients with this disease who started after the age of 702011

    • Author(s)
      Ikeda S, Tojo K, Sekijima Y, Yazaki M
    • Organizer
      VIIIth International Symposium on Familial Amyloidotic Polyneuropathy
    • Place of Presentation
      The Kumamoto City Medical Association Hall(Kumamoto)
    • Related Report
      2011 Research-status Report
  • [Book] Familial Transthyretin Amyloidosis (January 2012) in: Gene Reviews at GeneTests : Medical Genetics Information Resource2012

    • Author(s)
      Sekijima Y, Yoshida K, Tokuda T, Ikeda S
    • Publisher
      Copyright, University of Washington, Seattle (database online)
    • URL

      http://www.genetests.org.

    • Related Report
      2013 Final Research Report
  • [Book] 非家族性全身性アミロイドーシスの臨床:Annual Review神経20122012

    • Author(s)
      関島良樹(鈴木則宏ら編集)
    • Publisher
      中外医学社
    • Related Report
      2013 Final Research Report
  • [Book] 家族性アミロイドポリニューロパチー:新しい診断と治療のABC 75末梢神経障害2012

    • Author(s)
      関島良樹,池田修一(祖父江元編集)
    • Publisher
      最新医学社
    • Related Report
      2013 Final Research Report
  • [Book] Annual Review神経20122012

    • Author(s)
      関島良樹
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report
  • [Book] アミロイドニューロパチー:今日の治療指針2011年版2011

    • Author(s)
      関島良樹(山口徹,北原光夫,福井次矢編集)
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] トランスサイレチンアミロイドーシスに対する新規治療法の開発:アミロイドーシス診療のすべて2011

    • Author(s)
      関島良樹(山田正仁編集)
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療指針2011年版2011

    • Author(s)
      関島良樹
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report
  • [Book] アミロイドーシス診療のすべて2011

    • Author(s)
      関島良樹
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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