Identification of novel anti-neural and anti-endothelial cell antibodies for diagnosis and therapy of autoimmune-mediated encephalitis

• Project/Area Number: 23591239
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Gifu University
• Principal Investigator: KIMURA Akio 岐阜大学, 医学(系)研究科(研究院), 准教授 (00362161)
• Co-Investigator(Kenkyū-buntansha): YANO Takeo 三重大学, 地域イノベーション学研究科, 教授 (00569197)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 抗神経抗体 / 自己免疫介在性脳炎 / 傍腫瘍性神経症候群 / 抗血管内皮抗体 / プロテオーム解析 / 二次元免疫ブロット / 免疫沈降 / 質量分析

Research Abstract

We identified novel anti-neural and anti-endothelial cell antibodies in serum and cerebrospinal fluid samples from patients with autoimmune-mediated encephalitis, who had no previous reported anti-neural and anti-endothelial cell antibodies. To identify these novel antibodies, we employed two-dimensional immunoblotting or immunoprecepitation using human neuroblastoma cells, human brain microvascular endothelial cells, or rat brain homogenate as the antigen source. As a result, we identified antibodies against intracellular adhesion molecule 5 in serum from a patient with Hashimoto encephalitis, ryanodine receptor 1 in serum from a patient with paraneoplastic cerebellar degeneration, and myosin regulatory light chain 12A in cerebrospinal fluid from a patient with paraneoplastic limbic encephalitis.

Research Products

• [Journal Article] Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation (2013)
  • Author(s): Kimura A, Sakurai T, Yoshikura N
  • Journal Title: J Neuroinflammation Volume: 10 Pages: 39-39
  • Peer Reviewed
• [Journal Article] Is there a difference in gastric emptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms? (2013)
  • Author(s): Tanaka Y, Kato T, Kimura A(他11名)
  • Journal Title: I J Neurol Volume: 260 Pages: 1611-1616
  • Peer Reviewed
• [Journal Article] Corticosteroid therapy in a patient with cerebral amyloid angiopathy-related inflammation. (2013)
  • Author(s): Kimura A, Sakurai T, Yoshikura N, Hayashi Y, Takemura M, Takahashi H, Inuzuka T.
  • Journal Title: Journal of Neuroinflammation Volume: 10 Issue: 1 Pages: 39-39
  • DOI: 10.1186/1742-2094-10-39
  • Peer Reviewed
• [Journal Article] Is there a difference in gastric emptying between myotonic dystrophy type 1 patients with and without gastrointestinal symptoms? (2013)
  • Author(s): Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Araki H, Murase M, Nagaki M, Moriwaki H, Inuzuka T.
  • Journal Title: Journal of Neurology Volume: 印刷中 Issue: 6 Pages: 1611-1616
  • DOI: 10.1007/s00415-013-6842-1
  • Peer Reviewed
• [Journal Article] 変形性脊椎症を有する高齢者に発症したnonsystemic vasculitic neuropathyの1例 (2013)
  • Author(s): 山田 恵、田中優司、木村暁夫、香村彰宏、林 祐一、保住 功、小池春樹、祖父江 元、犬塚 貴
  • Journal Title: 日本老年医学会雑誌 Volume: 50 Pages: 400-403
  • NAID: 10031203258
  • Peer Reviewed
• [Journal Article] Elevated anti-heat shock protein 60 antibody titer is related to white matter hyperintensities (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M(他7名)
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 21 Pages: 305-309
  • Peer Reviewed
• [Journal Article] Anti-Endothelial Cell Antibodies in Patients with Cerebral Small Vessel Disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M(他9名)
  • Journal Title: Curr Neurovasc Res Volume: 9 Pages: 296-301
  • Peer Reviewed
• [Journal Article] Antibodies Against the Tom40 Subunit of the Translocase of the Outer Mitochondrial Membrane Complex and Cognitive Impairment in Alzheimer's Disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M(他9名)
  • Journal Title: J Alzheimers Dis Volume: 29 Pages: 373-377
  • Peer Reviewed
• [Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough (2012)
  • Author(s): Yamaguchi Y, Hayashi A, Kimura A(他3名、)
  • Journal Title: J Biol Chem Volume: 287 Pages: 17765-17776
  • Peer Reviewed
• [Journal Article] Late-onset patients with sporadic amyotrophic lateral sclerosis in Japan have a higher progression rate of ALSFRS-R at the time of diagnosis (2012)
  • Author(s): Tanaka Y, Yoshikura N, Kimura A(他7名)
  • Journal Title: Intern Med Volume: 51 Pages: 579-584
  • NAID: 130002061913
  • Peer Reviewed
• [Journal Article] Peduncular hallucinations in brainstem encephalitis drawn by a patient (2012)
  • Author(s): Hayashi Y, Yoshikura N, Kimura A(他1名)
  • Journal Title: Neurology Volume: 79 Pages: 1625-1625
  • Peer Reviewed
• [Journal Article] Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the (13) C-acetate breath test (2012)
  • Author(s): Tanaka Y, Kato T, Kimura A(他11名)
  • Journal Title: J Neurol Volume: 259 Pages: 1448-1452
  • Peer Reviewed
• [Journal Article] Specific Detection by the Polymerase Chain Reaction of Potentially Allergenic Salmonid Fish Residues in Processed Foods (2012)
  • Author(s): Ishizaki S, Sakai Y, Yano T(他6名)
  • Journal Title: Biosci. Biotechnol. Biochem Volume: 76 Pages: 980-985
  • NAID: 10030752985
  • Peer Reviewed
• [Journal Article] Anti-Endothelial Cell Antibodies in Patients with Cerebral Small Vessel Disease. (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T.
  • Journal Title: Current Neurovascular Research Volume: 9 Issue: 4 Pages: 296-301
  • DOI: 10.2174/156720212803530726
  • Peer Reviewed
• [Journal Article] Antibodies against the tom40 subunit of the translocase of the outer mitochondrial membrane complex and cognitive impairment in Alzheimer's disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T
  • Journal Title: Journal of Alzheimer's Disease Volume: 29 Issue: 2 Pages: 373-377
  • DOI: 10.3233/jad-2011-111343
  • Peer Reviewed
• [Journal Article] Elevated anti-heat shock protein 60 antibody titer is related to white matter hyperintensities. (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Takemura M, Seishima M, Inuzuka T
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 21 Issue: 4 Pages: 305-309
  • DOI: 10.1016/j.jstrokecerebrovasdis.2010.09.003
  • Peer Reviewed
• [Journal Article] Peduncular hallucinations in brainstem encephalitis drawn by a patient. (2012)
  • Author(s): Hayashi Y, Yoshikura N, Kimura A, Inuzuka T.
  • Journal Title: Neurology Volume: 79 Issue: 15 Pages: 1625-1625
  • DOI: 10.1212/wnl.0b013e31826e2673
  • Peer Reviewed
• [Journal Article] Is there delayed gastric emptying in patients with multiple system atrophy? An analysis using the (13)C-acetate breath test. (2012)
  • Author(s): Tanaka Y, Kato T, Nishida H, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Araki H, Murase M, Nagaki M, Moriwaki H, Inuzuka T.
  • Journal Title: Journal of Neurology Volume: 259 Issue: 7 Pages: 1448-1452
  • DOI: 10.1007/s00415-011-6372-7
  • Peer Reviewed
• [Journal Article] L-MPZ, a novel isoform of myelin P0, is produced by stop codon readthrough. (2012)
  • Author(s): Yamaguchi Y, Hayashi A, Campagnoni CW, Kimura A, Inuzuka T, Baba H.
  • Journal Title: The Journal of Biological Chemistry Volume: 287 Issue: 21 Pages: 17765-17776
  • DOI: 10.1074/jbc.m111.314468
  • Peer Reviewed
• [Journal Article] Late-onset Patients with Sporadic Amyotrophic Lateral Sclerosis in Japan have a Higher Progression Rate of ALSFRS-R at the Time of Diagnosis (2012)
  • Author(s): Tanaka Y, Yoshikura N, Harada N, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Inuzuka T.
  • Journal Title: Internal Medicine Volume: 51 Issue: 6 Pages: 579-584
  • DOI: 10.2169/internalmedicine.51.6148
  • NAID: 130002061913
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Antibodies Against the Tom40 Subunit of the Translocase of the Outer Mitochondrial Membrane Complex and Cognitive Impairment in Alzheimer's Disease. (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Takemura M, Seishima M, Inuzuka T.
  • Journal Title: Journal of Alzheimers Disease Volume: 29 Pages: 373-377
  • Peer Reviewed
• [Journal Article] Neuromyelitis optica in Japanese sisters. (2011)
  • Author(s): Tanaka Y, Yoshikura N, Harada N, Yamada M, Koumura A, Sakurai T, Hayashi Y, Kimura A, Hozumi I, Moriwaki H, Inuzuka T.
  • Journal Title: Internal Medecine Volume: 50 Pages: 2829-2832
  • NAID: 130001288674
  • Peer Reviewed
• [Journal Article] Diffuse skeletal muscles uptake of [18F] fluorodeoxyglucose on positron emission tomography in primary muscle peripheral T-cell lymphoma. (2011)
  • Author(s): Tanaka Y, Hayashi Y, Kato J, Yamada M, Koumura A, Sakurai T, Kimura A, Hozumi I, Hatano Y, Hirose Y, Takami T, Nakamura H, Kasahara S, Tsurumi H, Moriwaki H, Inuzuka T.
  • Journal Title: Internal Medecine Volume: 50 Pages: 2021-2024
  • NAID: 130000969316
  • Peer Reviewed
• [Journal Article] Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T (2011)
  • Author(s): Hozumi I, Hasegawa T, Honda A, Ozawa K, Hayashi Y, Hashimoto K, Yamada M, Koumura A, Sakurai T, Kimura A, Tanaka Y, Satoh M, Inuzuka T
  • Journal Title: Journal of Neurological Sciences Volume: 303 Pages: 95-99
  • Peer Reviewed
• [Journal Article] Identification of antibodies as biological markers in serum from multiple sclerosis patients by immunoproteomic approach. (2011)
  • Author(s): Sakurai T, Kimura A, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Inuzuka T
  • Journal Title: Journal of Neuroimmunology Volume: 233 Pages: 175-180
  • Peer Reviewed
• [Presentation] 免疫介在性ニューロパチーにおける血清BAFF値と臨床所見との関連性の検討 (2013)
  • Author(s): 木村暁夫、吉倉延亮、原田斉子、香村彰宏、林祐一、犬塚貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
  • Year and Date: 2013-11-27
• [Presentation] 亜急性小脳失調症における新規抗神経抗体の同定 (2013)
  • Author(s): 香村彰宏、木村暁夫、吉倉延亮、原田斉子、林祐一、犬塚貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
  • Year and Date: 2013-11-27
• [Presentation] 自己抗体関連脳炎における髄液中BAFF,APRIL値の検討 (2013)
  • Author(s): 吉倉延亮、木村暁夫、香村彰宏、原田斉子、林祐一、犬塚貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
  • Year and Date: 2013-11-27
• [Presentation] 急性の認知機能低下を主訴とし肺小細胞癌を合併した抗ANPA受容体抗体陽性辺縁系脳炎の1例 (2013)
  • Author(s): 原田斉子、林祐一、吉倉延亮、香村彰宏、木村暁夫、犬塚貴
  • Organizer: 第134回日本神経学会東海北陸地方会
  • Place of Presentation: 金沢
  • Year and Date: 2013-10-20
• [Presentation] 辺縁系脳炎、急性運動感覚性ニューロパチーを呈した抗Hu抗体陽性傍腫瘍症候群の1例 (2013)
  • Author(s): 櫻井岳朗、脇田賢治、西田浩、木村暁夫、犬塚貴
  • Organizer: 第134回日本神経学会東海北陸地方会
  • Place of Presentation: 金沢
  • Year and Date: 2013-10-20
• [Presentation] ACTH単独欠損症に生じたインフルエンザ脳症の2例 (2013)
  • Author(s): 瀬川一、林祐一、吉倉延亮、櫻井岳郎、原田斉子、香村彰宏、木村暁夫、牛越博昭、諏訪哲也、犬塚貴
  • Organizer: 第18回日本神経感染症学会総会
  • Place of Presentation: 宮崎
  • Year and Date: 2013-10-11
• [Presentation] リツキシマブ投与にて症状改善を得た、治療抵抗性のStiff-person症候群の1例 (2013)
  • Author(s): 吉倉延亮、林祐一、原田斉子、香村彰宏、木村暁夫、犬塚貴
  • Organizer: 第133回日本神経学会東海北陸地方会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-07-07
• [Presentation] 亜急性小脳失調症における新規抗神経抗体の同定 (2013)
  • Author(s): 香村彰宏、木村暁夫、原田斉子、吉倉延亮、林祐一、犬塚貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-31
• [Presentation] CAA関連炎症・血管炎に対するステロイド治療と髄液マーカーの検索 (2013)
  • Author(s): 木村暁夫、吉倉延亮、原田斉子、香村彰宏、林祐一、犬塚貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-29
• [Presentation] 自己免疫性中枢性神経疾患患者における血清BAFF, APRIL値の検討 (2013)
  • Author(s): 吉倉延亮、香村彰宏、木村暁夫、原田斉子、林祐一、犬塚貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-29
• [Presentation] Pure motor chronic inflammatory demyelinating polyneuropathy (2013)
  • Author(s): Kimura A, Koumura A, Sakurai T, Hayashi Y, Inuzuka T.
  • Organizer: The 65^<th> Annual Meeting of American Academy of Neurology
  • Place of Presentation: San Diego
  • Year and Date: 2013-03-18
• [Presentation] 痙攣重積で発症した若年男性の腫瘍非合併抗NMDA受容体抗体陽性脳炎の1例 (2013)
  • Author(s): 櫻井岳朗、林祐一、武田明子、原田斉子、吉倉延亮、香村彰宏、木村暁夫、犬塚貴
  • Organizer: 第132回日本神経学会東海北陸地方会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-03-03
• [Presentation] Pure Motor Chronic Inflammatory Demyelinating Polyneuropathy (2013)
  • Author(s): Kimura A, Koumura A, Sakurai T, Hayashi Y, Inuzuka T
  • Organizer: The 65th American Academy of Neurology
  • Place of Presentation: San Diego, USA
• [Presentation] 単純血漿交換療法およびIVIg療法が有効であった抗mGluR1抗体陽性亜急性小脳失調症の1例 (2012)
  • Author(s): 原田斉子、林祐一、吉倉延亮、香村彰宏、木村暁夫、犬塚貴
  • Organizer: 第30回日本神経治療学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2012-11-30
• [Presentation] 多発性筋炎患者における抗MYBPC2抗体および抗PK M1/M2抗体の同定と特異性の検討 (2012)
  • Author(s): 木村暁夫、櫻井岳朗、吉倉延亮、山田恵、林祐一、田中優司、保住功、大瀧博文、帖佐光洋、犬塚貴
  • Organizer: 第23回日本神経免疫学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-15
• [Presentation] 自己免疫介在性脳炎・脳症における新規自己抗体の同定 (2012)
  • Author(s): 木村暁夫、櫻井岳朗、吉倉延亮、原田斉子、香村彰宏、林祐一、犬塚貴
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-24
• [Presentation] Anti-endothelial cell antibodies in patients with Alzheimer disease (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Otaki H, Chousa M, Inuzuka T.
  • Organizer: The 64^<th> Annual Meeting of American Academy of Neurology
  • Place of Presentation: New Orleans
  • Year and Date: 2012-04-25
• [Presentation] Aβ関連血管炎患者における血清・髄液中Aβ抗体の検討 (2012)
  • Author(s): 木村暁夫、櫻井岳朗、吉倉延亮、原田斉子、香村彰宏、林祐一、犬塚貴
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 軽井沢
• [Presentation] Anti-Endothelial Cell Antibodies in Patients with Alzheimer Disease. (2012)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Ohtaki H, Chousa M, Inuzuka T.
  • Organizer: The 64th American Academy of Neurology
  • Place of Presentation: New Orleans, USA
• [Presentation] The Clinical Characteristics of Aseptic Meningitis with Selective IgG Subclass 3 Deficiency. (2012)
  • Author(s): Hayashi Y, Yamada M, Yoshikura N, Harada N, Kohmura A, Sakurai T, Kimura A, Hozumi I, Inuzuka T
  • Organizer: The 64th American Academy of Neurology
  • Place of Presentation: New Orleans, USA
• [Presentation] 自己免疫介在性脳炎･脳症における新規自己抗体の同定 (2012)
  • Author(s): 木村暁夫、櫻井岳郎、吉倉延亮、原田斉子、香村彰宏、林 祐一、犬塚 貴
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Aβ血管炎患者における血清・髄液中抗Aβ42抗体の検討 (2012)
  • Author(s): 木村暁夫、櫻井岳郎、吉倉延亮、原田斉子、香村彰宏、林 祐一、犬塚 貴
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 軽井沢・長野
• [Presentation] 頻回の呼吸停止をきたし、単純血漿交換が著効したstiff-person症候群の1例 (2011)
  • Author(s): 吉倉延亮、林祐一、山田恵、原田斉子、香村彰宏、木村暁夫、田中優司、保住功、犬塚貴
  • Organizer: 第29回日本神経治療学会総会
  • Place of Presentation: 福井
  • Year and Date: 2011-11-18
• [Presentation] プロテオーム解析を用いた大脳白質病変に関連する抗血管内皮細胞抗体の同定 (2011)
  • Author(s): 木村暁夫、櫻井岳朗、山田恵、香村彰宏、林祐一、田中優司、保住功、犬塚貴
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-20
• [Presentation] 新規自己抗体による多発性硬化症の血清学的診断マーカーの検索 (2011)
  • Author(s): 櫻井岳朗、木村暁夫、原田斉子、吉倉延亮、山田恵、香村彰宏、林祐一、田中優司、保住功、犬塚貴
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] Anti-endothelial cell antibodies in the Elderly with Extended White Matter Hyperintensity (2011)
  • Author(s): Kimura A, Sakurai T, Yamada M, Koumura A, Hayashi Y, Tanaka Y, Hozumi I, Otaki H, Chousa M, Takemura M, Seishima M, Inuzuka T.
  • Organizer: The 63^<th> Annual Meeting of American Academy of Neurology
  • Place of Presentation: Honolulu
  • Year and Date: 2011-04-13
• [Presentation] Anti-Endothelial Cell Antibodies in the Elderly with Extended White Matter Hyperintensity. (2011)
  • Author(s): A. Kimura, T. Sakurai, M. Yamada, A. Koumura, Y. Hayashi, Y. Tanaka, I. Hozumi, H. Ohtaki, M. Chousa, M. Takemura, M. Seishima, and T. Inuzuka.
  • Organizer: 63rd American Academy of Neurology annual meeting.
  • Place of Presentation: Honolulu, USA
• [Presentation] 多発性筋炎患者における抗MYBPC2抗体および抗PK M1/M2抗体の同定と特異性の検討 (2011)
  • Author(s): 木村暁夫, 櫻井岳郎, 吉倉延亮, 山田 恵, 林 祐一, 田中優司, 保住 功, 大瀧博文, 帖佐光洋, 犬塚 貴.
  • Organizer: 第23回日本神経免疫学会学術集会.
  • Place of Presentation: 東京
• [Presentation] CAA関連炎症・血管炎に対するステロイド治療と髄液マーカーの検索
  • Author(s): 木村暁夫、吉倉延亮、原田斉子、香村彰宏、林 祐一、犬塚 貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 自己免疫性中枢性神経疾患患者における血清BAFF, APRIL値の検討
  • Author(s): 吉倉延亮、香村彰宏、木村暁夫、原田斉子、林 祐一、犬塚 貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 亜急性小脳失調症における新規抗神経抗体の同定
  • Author(s): 香村彰宏、木村暁夫、原田斉子、吉倉延亮、林 祐一、犬塚 貴
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 免疫介在性ニューロパチーにおける血清BAFF値と臨床所見との関連性の検討
  • Author(s): 木村暁夫、吉倉延亮、原田斉子、香村彰宏、林 祐一、犬塚 貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
• [Presentation] 亜急性小脳失調症における新規抗神経抗体の同定
  • Author(s): 香村彰宏、木村暁夫、吉倉延亮、原田斉子、林 祐一、犬塚 貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
• [Presentation] 自己抗体関連脳炎における髄液中BAFF,APRIL値の検討
  • Author(s): 吉倉延亮、木村暁夫、香村彰宏、原田斉子、林 祐一、犬塚 貴
  • Organizer: 第25回日本神経免疫学会学術集会
  • Place of Presentation: 下関
• [Presentation] 多発性硬化症患者における髄液中抗神経抗体の検討
  • Author(s): 木村暁夫、吉倉延亮、原田斉子、香村彰宏、林 祐一、犬塚 貴
  • Organizer: 第5５回日本神経学会学術大会
  • Place of Presentation: 博多