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Clinical pictures and neuromuscular junction pathomechanism in novel LDL- recepotr related protein 4 antibody-positive myasthenia gravis

Research Project

Project/Area Number 23591248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionNagasaki Institute of Applied Science (2013)
Nagasaki University (2011-2012)

Principal Investigator

MOTOMURA Masakatsu  長崎総合科学大学, 工学部, 教授 (70244093)

Co-Investigator(Kenkyū-buntansha) FUKUDA Taku  長崎大学, 大学病院, 研究員 (50437894)
YOSHIMURA Toshiro  長崎大学, 大学院医歯薬学総合研究科, 教授 (80182822)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords重症筋無力症 / 自己抗体 / 神経筋接合部疾患 / 新規自己抗体 / Lrp4 / LDL受容体関連蛋白質4 / アセチルコリン受容体 / 筋特異的受容体型チロシンキナーゼ
Research Abstract

Myasthenia gravis (MG) is caused by the failure of neuromuscular transmission mediated by pathogenic autoantibodies (Abs) against acetylcholine receptor (AChR) and muscle-specific receptor tyrosine kinase (MuSK). The seropositivity rates for routine AChR binding Ab and MuSK Ab in MG are 80-85% and 5-10% for MG patients in Japan, respectively. In 2011, autoantibodies against low-density lipoprotein receptor-related protein 4 (Lrp4) were identified in Japanese MG patients. We developed a simple technique termed Gaussia luciferase immunoprecipitation for detecting antibodies to Lrp4. As a result, nine generalized MG patients from 300 lacking AChR Ab are positive for Lrp4 antibodies. These antibodies inhibit binding of Lrp4 to its ligand and are predominantly of the IgG1 subclass. Further studies including neuromuscular junction biopsy are needed to clarify the pathomechanism of Lrp4 ab positive MG. These results indicate that Lrp4 is a third pathogenic autoantigen in patients with MG.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (67 results)

All 2013 2012 2011

All Journal Article (37 results) (of which Peer Reviewed: 12 results) Presentation (30 results)

  • [Journal Article] Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis2013

    • Author(s)
      Takamori M, Nakamura T, Motomura M
    • Journal Title

      J Neuroimmunol

      Volume: 254(1-2) Pages: 183-186

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific recept or tyrosine kinase-antibody-positive myasthenia gravis2013

    • Author(s)
      Nakata R, Motomura M, Masuda T, Shiraishi H, Tokuda M, Fukuda T, Ando T, Yoshimura T, Tsujihata M, Kawakami A
    • Journal Title

      Eur J Neurol

      Volume: 20(9) Pages: 1272-1276

    • NAID

      120006986118

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射性免疫測定法による筋特異的受容体型チロシンキナーゼ抗体測定キットの基礎的・臨床的検討2013

    • Author(s)
      本村政勝,中田るか,白石裕一,枡田智子,福田卓,徳田昌紘,中嶋秀樹,宮崎禎一郎,向野晃弘,前田泰宏,太田理絵,吉村俊祐,吉村俊朗,川上純,佐藤聡,辻畑光宏, 菊池強
    • Journal Title

      医学と薬学

      Volume: 70(2) Pages: 421-428

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症の診療-最近の進歩-2013

    • Author(s)
      樋口理,本村政勝
    • Journal Title

      Neuroligical Science

      Volume: 19-20 Pages: 10-11

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症2013

    • Author(s)
      本村政勝,中田るか,白石裕一
    • Journal Title

      日本医師会雑誌

      Volume: 142(2) Pages: 238-239

    • NAID

      130005279096

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症、ランバートイートン筋無力症候群2013

    • Author(s)
      中田るか,本村政勝
    • Journal Title

      疾患・症状別今日の治療と看護

      Volume: 改定第3版 Pages: 773-776

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症2013

    • Author(s)
      本村政勝
    • Journal Title

      今日の神経疾患治療指針

      Volume: 2 Pages: 173-177

    • NAID

      130005279096

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症の自己抗体2013

    • Author(s)
      本村政勝,成田智子
    • Journal Title

      BRAIN andNERVE

      Volume: 65(4) Pages: 433-439

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症と新規自己抗体2013

    • Author(s)
      永石彰子,酒井和香,本村政勝
    • Journal Title

      日本臨床

      Volume: 71 Pages: 876-880

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症2013

    • Author(s)
      永石彰子,本村政勝
    • Journal Title

      耳鼻咽喉科・頭頸部外科

      Volume: 85(6) Pages: 444-448

    • NAID

      130005279096

    • Related Report
      2013 Final Research Report
  • [Journal Article] Lambert-Eaton筋無力症候群2013

    • Author(s)
      本村政勝
    • Journal Title

      内科学

      Pages: 2316-2318

    • Related Report
      2013 Final Research Report
  • [Journal Article] Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis.2013

    • Author(s)
      Nakata R, Motomura M, Masuda T, Shiraishi H, Tokuda M, Fukuda T, Ando T,Yoshimura T, Tsujihata M, Kawakami A.
    • Journal Title

      Eur J Neurol.

      Volume: 20 Issue: 9 Pages: 1272-6

    • DOI

      10.1111/ene.12169

    • NAID

      120006986118

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis.2013

    • Author(s)
      Takamori M, Nakamura T, Motomura M.
    • Journal Title

      J Neuroimmunol.

      Volume: 254 Issue: 1-2 Pages: 183-6

    • DOI

      10.1016/j.jneuroim.2012.09.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis2012

    • Author(s)
      Imai T, Tsuda E, Hozuki T, Yoshikawa H, Yamauchi R, Saitoh M, Hisahara S, Motomura M, Kawamata J, Shimohama S
    • Journal Title

      Clin Neurophysiol

      Volume: 123(6) Pages: 1242-1247

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis2012

    • Author(s)
      Imai T, Tsuda E, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomura M, Kawamata J, Shimohama S
    • Journal Title

      Clin Neurophysiol

      Volume: 123(9) Pages: 1886-1890

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies against the main immunogenic region of the acetylchol ine receptor correlate with disease severity in myasthenia gravis2012

    • Author(s)
      Masuda T, Motomura M, Utsugisawa K, Nagane Y, Nakata R, Tokuda M, Fukuda T, Yoshimura T, Tsujihata M, Kawakami A
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83(9) Pages: 935-940

    • NAID

      120006985571

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of Japanese spotted fever Complicated with central nervous System involvement and multiple organ failure2012

    • Author(s)
      Nakata R, Motomura M, Tokuda M, Nakajima H, Masuda T, Fukuda T, Tsujino A,Yoshimura T, Kawakami A
    • Journal Title

      Intern Med

      Volume: 51(7) Pages: 783-786

    • NAID

      130002061829

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Childhood-onset anti-MuSK antibody positive myasthenia gravis demonstrates a distinct clinical course2012

    • Author(s)
      Takahashi Y,Sugiyama M, Ueda Y, Itoh T, Yagyu K, Shiraishi H, Ukeba-Terashita Y, Nakanishi M, Nagashima T, Imai T, Motomura M, Saitoh S
    • Journal Title

      Brain Dev

      Volume: 34(9) Pages: 784-786

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【神経難病のリハビリテーション-症例を通して学ぶ】(第2章)症例を通して学ぶ神経難病のリハビリテーション重症筋無力症嚥下障害を主訴とする症例2012

    • Author(s)
      本村政勝,石飛進吾,大久保英梨子
    • Journal Title

      Journal of Clinical Rehabilitation

      Volume: 別冊(神経難病のリハビリテーション-症例を通して学ぶ) Pages: 183-187

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【知っておきたい内科症候群】神経・筋《腫瘍関連症候群》ランバート・イートン筋無力症候群2012

    • Author(s)
      中根俊成,本村政勝
    • Journal Title

      内科

      Volume: 109(6) Pages: 944-946

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【最新の神経難病治療と今後の展望】重症筋無力症2012

    • Author(s)
      中嶋秀樹,本村政勝
    • Journal Title

      医薬ジャーナル

      Volume: 48(5) Pages: 1317-1323

    • Related Report
      2013 Final Research Report
  • [Journal Article] 重症筋無力症の進歩:Lrp4抗体陽性MGの発見2012

    • Author(s)
      本村政勝,樋口理
    • Journal Title

      臨床神経

      Volume: 52(11) Pages: 1303-1305

    • NAID

      130004505142

    • Related Report
      2013 Final Research Report
  • [Journal Article] 第6章:神経・筋疾患の医療ニーズ第7節重症筋無力症2012

    • Author(s)
      本村政勝,向野晃弘,福留隆泰
    • Journal Title

      希少疾患/難病の診断・治療と製品開発

      Volume: (抜刷)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 抗MuSK抗体陽性重症筋無力症の重症診断と治療2012

    • Author(s)
      白石雄一,本村政勝
    • Related Report
      2013 Final Research Report
  • [Journal Article] 【コリン作動性シナプスの基礎と臨床】コリン作動性シナプスの病態と治療重症筋無力症2012

    • Author(s)
      宮崎禎一郎,本村政勝
    • Journal Title

      ClinicalNeuroscience

      Volume: 30(6) Pages: 680-684

    • Related Report
      2013 Final Research Report
  • [Journal Article] Prednisoloneが奏効した先天性筋無力症候群の兄弟例2012

    • Author(s)
      福留隆泰,田中竜太,本村政勝,東慶,大野欽司
    • Journal Title

      神経治療学

      Volume: 29(5) Pages: 627-627

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 重症筋無力症治療の基本2012

    • Author(s)
      本村政勝
    • Journal Title

      神経治療学

      Volume: 29(5) Pages: 596-596

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【免疫性神経疾患の治療:標準的治療とトピックス】重症筋無力症2012

    • Author(s)
      吉村俊祐,本村政勝
    • Journal Title

      神経治療学

      Volume: 29(1) Pages: 15-21

    • Related Report
      2013 Final Research Report
  • [Journal Article] Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis2011

    • Author(s)
      Imai T, Tsuda E, Hozuki T, Yoshikawa H, Yamauchi R, Saitoh M, Hisahara S, Motomura M, Kawamata J, Shimohama S
    • Journal Title

      Clin Neurophysiol

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of myasthenia gravis according to onset-age : Japanese nationwide survey2011

    • Author(s)
      Murai H, Yamashita N, Watanabe M, Nomura Y, Motomura M, Yoshikawa H, Nakamura Y, Kawaguchi N, Onodera H, Araga S, Isobe N, Nagai M, Kira J
    • Journal Title

      J Neurol Sci

      Volume: 305(1-2) Pages: 97-102

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗MuSK抗体陽性の重症筋無力症の妊婦例と新生児一過性重症筋無力症児例2011

    • Author(s)
      神崎昭浩,本村政勝
    • Journal Title

      臨床神経学

      Volume: 51(3) Pages: 188-191

    • NAID

      10031163994

    • Related Report
      2013 Final Research Report
  • [Journal Article] 各種疾患筋肉疾患抗MuSK抗体陽性重症筋無力症2011

    • Author(s)
      本村政勝,白石裕一
    • Journal Title

      Annual Review神経

      Pages: 328-336

    • Related Report
      2013 Final Research Report
  • [Journal Article] 各種難病の最新治療情報重症筋無力症の最新の薬物療法情報2011

    • Author(s)
      中田るか,本村政勝
    • Journal Title

      難病と在宅ケア

      Volume: 17(4) Pages: 47-50

    • NAID

      40018904095

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【神経筋接合部基礎から臨床まで】Lambert-Eaton筋無力症候群2011

    • Author(s)
      本村政勝,福田卓
    • Journal Title

      BRAIN and NERVE :神経研究の進歩

      Volume: 63(7) Pages: 745-754

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【神経筋接合部基礎から臨床まで】神経筋接合部病態の定性・定量的評価超微形態と組織化学2011

    • Author(s)
      吉村俊朗,本村政勝,辻畑光宏
    • Journal Title

      BRAIN and NERVE :神経研究の進歩

      Volume: 63(7) Pages: 719-727

    • Related Report
      2013 Final Research Report
  • [Journal Article] 高齢発症重症筋無力症の標準的神経治療2011

    • Author(s)
      本村政勝
    • Journal Title

      臨床神経学

      Volume: 51(8) Pages: 576-582

    • NAID

      10031164041

    • Related Report
      2013 Final Research Report
  • [Journal Article] utoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis.2011

    • Author(s)
      Higuchi O, Hamuro J, Motomura M, Yamanashi Y.
    • Journal Title

      Ann Neurol.

      Volume: 69 Pages: 418-422

    • Related Report
      2011 Research-status Report
  • [Presentation] 当科における眼筋性重症筋無力症の治療成績:ステロイドパルスを含めたステロイド治療の有用性2013

    • Author(s)
      本村政勝
    • Organizer
      第110回日本内科学会総会・講演会
    • Place of Presentation
      東京国際フォーラム(一般講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 受動免疫性重症筋無力症ラットの神経筋接合部分子病態2013

    • Author(s)
      本村政勝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(一般講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 多発性硬化症および視神経脊髄炎におけるカリウムチャネル(KIR4.1)抗体の意義2013

    • Author(s)
      中嶋秀樹,本村政勝,向野晃弘,吉村俊祐,宮崎禎一郎,中田るか,成田智子,吉村俊朗,川上純
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 本邦の小児MuSK抗体陽性重症筋無力症の検討2013

    • Author(s)
      中田るか,本村政勝,成田智子,吉村俊祐,向野晃弘,中嶋秀樹,宮崎禎一郎,吉村俊朗,川上純
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] MuSK/Lrp4に対する自己抗体の最新知見2013

    • Author(s)
      本村政勝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ランチョンセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] MuSK抗体陽性重症筋無力症治療の現状2013

    • Author(s)
      本村政勝
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(イブニングセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] 入院中2度の筋無力症クリナーゼを起こし、繰り返しの単純血漿交換療法が有効であった抗MuSK抗体重症筋無力症の1例2013

    • Author(s)
      本村政勝
    • Organizer
      第34回日本アフェレシス学会学術大会
    • Place of Presentation
      軽井沢プリンスホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] 受動免疫性重症筋無力症ラットの神経筋接合部分子病態2013

    • Author(s)
      本村政勝, 吉村俊祐, 吉村俊郎, 成田智子, 中田るか, 向野晃弘, 宮崎禎一郎, 中嶋秀樹, 福田 卓, 川上 純, 江口円俊, 樋口 理, 辻畑光宏
    • Organizer
      第54回 日本神経学会学術大会 東京国際フォーラム
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 免疫グロブリン大量療法とタクロリムスが奏功した高齢発症の抗MuSK抗体陽性全身型重症筋無力症の1例2012

    • Author(s)
      本村政勝
    • Organizer
      第198回日本神経学会九州地方会
    • Place of Presentation
      長崎大学
    • Year and Date
      2012-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] MORPHOMETRIC ANALYSIS Moter END-PLATES IN PATIENTS IN WITH CIBENZOLINE SUCCINATE OVERDOSE AND LAMBERT EATON MYASTHENIC SYNDROME2012

    • Author(s)
      Yoshimura T, Motomura M, Iwanaga H, Fukuda T, Tujino A, Masuda T, Yoshimura S,Kawakami A, Tsujihata M
    • Organizer
      12^<th> International Conference on Myasthenia Gravis and Related Disorders
    • Place of Presentation
      The New York Academy of Sciences(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] FINE STRUCTURE OF THE NEUROMUSCULAR JUNCTION IN PATIENTS WITH ANTI-LPR4 ANTIBODY-POSITIVE MYASTHENIA GRAVIS2012

    • Author(s)
      Yoshimura S, Yoshimura T, Motomura M, Myazaki T,Nakata R,Nakajima H, Fukuda T
    • Organizer
      12^<th> International Conference on Myasthenia Gravis and Related Disorders
    • Place of Presentation
      The New York Academy of Sciences(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] ANTI-BODIES BINDING TO THE MAIN IMMUNOGENIC REGION OF THE NICOTINIC ACETYLCHOLINE RECEPTORS CORRELATE MYASTHENIA GRAVIS SAVERITY2012

    • Author(s)
      Motomura M, Masuda T, Utsugisawa K, Nagane Y, Tokuda M, Yoshimura T, Tsujihata M, Kawakami A
    • Organizer
      12^<th> International Conference on Myasthenia Gravis and Related Disorders
    • Place of Presentation
      The New York Academy of Sciences(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] Structure of the Neuromuscular Juction : Function and Cooperative Mechanisims in the Synapse2012

    • Author(s)
      Takamori M, Nakamura T, Motomura M
    • Organizer
      12^<th> International Conference on Myasthenia Gravis and Related Disorders
    • Place of Presentation
      The New York Academy of Sciences(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 生物発光を利用した重症筋無力症関連自己抗体測定法の確立2012

    • Author(s)
      白石裕一,樋口理,中根俊成,本村政勝,枡田智子,松尾秀徳
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症におけるAChRMRI抗体価とその臨床像2012

    • Author(s)
      枡田智子,本村政勝,槍澤公明,長根百合子,中田るか,徳田昌紘,中嶋秀樹,宮崎禎一郎,吉村俊祐,福田卓,吉村俊朗,辻畑光宏,川上純
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗LRP4・MuSK抗体陽性患者の運動終板の微細構造2012

    • Author(s)
      吉村俊祐,吉村俊朗,本村政勝,福田卓,枡田智子,中田るか,中嶋秀樹,宮崎禎一郎,川上純
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] Lambert-Eaton筋無力症候群における嚥下機能障害に対する検討2012

    • Author(s)
      湯淺隆行,本村政勝,枡田智子,中田るか,佐藤聡,辻畑光宏,川上純,吉村俊朗,松下新子,久松徳子,小山善哉,石飛進吾
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] コハク酸シベンゾリンによる筋無力症候群とLEMSの運動終板の微細構造の差異2012

    • Author(s)
      吉村俊朗,吉村俊祐,本村政勝,岩永洋,福田卓,辻野彰,枡田智子,中嶋秀樹,宮崎禎一郎,川上純
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症の進歩:Lrp4抗体陽性MGの発見2012

    • Author(s)
      本村政勝,樋口理
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(シンポジウム講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症治療の基本2012

    • Author(s)
      本村政勝
    • Organizer
      第30回日本神経治療学会総会
    • Place of Presentation
      北九州国際会議場(ランチョンセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] 当科における眼筋型重症筋無力症の治療成績:ステロイドパルスを含めたステロイド2012

    • Author(s)
      宮崎禎一郎,本村政勝,枡田智子,中嶋秀樹,中田るか,吉村俊祐,向野晃弘,吉村俊朗,中村龍文
    • Organizer
      第24回日本神経免疫学会学術集会
    • Place of Presentation
      軽井沢プリンスホテル(ワークショップ)
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫性自律神経節障害=新しい自己抗体測定系の確立とその臨床像の解析2012

    • Author(s)
      本村政勝
    • Organizer
      第24回日本神経免疫学会学術集会
    • Place of Presentation
      軽井沢プリンスホテル(シンポジウム講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗MuSK抗体陽性重症筋無力症患者の呼吸不全に対してコリンエステラーゼ阻害薬が有用であった1例2012

    • Author(s)
      吉村俊祐,本村政勝,枡田智子,向野晃弘,宮崎禎一郎,中田るか,中嶋秀樹,川上純,吉村俊朗
    • Organizer
      第24回日本神経免疫学会学術集会
    • Place of Presentation
      軽井沢プリンスホテル(ポスター発表)
    • Related Report
      2013 Final Research Report
  • [Presentation] 新たな病因自己抗体、Lrp4抗体陽性重症筋無力症(MG)の発見2011

    • Author(s)
      枡田智子,本村政勝,徳田昌紘,福田卓,辻野彰,川上純,吉村俊朗,森雅裕,樋口理,山梨裕司
    • Organizer
      第108回日本内科学会総会・講演会
    • Place of Presentation
      東京国際フォーラム(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症と自己免疫疾患の合併;臨床的特徴と自己抗体の検索2011

    • Author(s)
      中田るか,中嶋秀樹,枡田智子,徳田昌紘,福田卓,辻野彰,本村政勝,中村龍文,吉村俊朗,川上純
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症におけるAchR MIR抗体価とその臨床像2011

    • Author(s)
      枡田智子,本村政勝,中田るか,徳田昌紘,福田卓,辻野彰,中嶋秀樹,立石洋平,吉村俊朗,川上純
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] コリンエステラーゼ阻害剤投与マウスとCollargenQ欠損マウスにおける運動終板微細構造の比較2011

    • Author(s)
      吉村俊朗,伊藤美佳子,片岡英樹,福留隆泰,Krejci Eric,岡田尚己,武田伸一,本村政勝,辻野彰,吉村俊祐,枡田智子,中田るか,徳田昌紘,福田卓,大野欽司
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(ポスター)
    • Related Report
      2013 Final Research Report
  • [Presentation] 自己免疫性神経筋接合部疾患の病態と治療2011

    • Author(s)
      本村政勝
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋国際会議場(教育講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] MG LDL受容体関連蛋白4(Lrp4)抗体陽性重症筋無力症の臨床2011

    • Author(s)
      本村政勝
    • Organizer
      第23回日本神経免疫学会学術集会
    • Place of Presentation
      京王プラザホテル(シンポジウム)
    • Related Report
      2013 Final Research Report
  • [Presentation] 重症筋無力症の最近の話題抗MuSK抗体を含めたAChR抗体陰性MG2011

    • Author(s)
      本村政勝
    • Organizer
      第23回日本神経免疫学会学術集会
    • Place of Presentation
      京王プラザホテル(シンポジウム)
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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