| Project/Area Number |
23591255
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
BABA Akiyasu 北里大学, 医学部附属病院, 研究員 (60296572)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 自己抗体 / 重症筋無力症 / 炎症性筋疾患 / 抗Kv1.4抗体 / 抗SRP抗体 / 電位依存性Kチャネル / 免疫沈降法 / 信号認識粒子 |
|---|
| Research Abstract |
Anti-signal recognition particle (SRP) antibodies were first found in the serum from a patient with polymyositis and were classified as one of the myositis-specific antibodies. We advocate for clinical recognition of a chronic form of anti-SRP myopathy, usually progressed over one year.
Anti-Kv1.4 antibody was detected by an immunoprecipitation assay using 35S-labeled rhabdomyosarcome cellular extract as the antigen source. Patients with anti-Kv1.4 antibodies showed higher frequencies of thymoma recurrence and MG relapse compared to those without. Anti-Kv1.4 antibody is a useful predictor of the prognosis of thymoma-associated MG. In addition, 70 (10.8%) of 650 MG patients had anti-Kv1.4 antibodies and 60% of them had abnormal ECG findings with high frequencies of T-wave abnormality and QT prolongation. Myocarditis was found in 8 MG patients with anti-Kv1.4 antibodies. Most patients showed rapid deterioration with lethal arrhythmias and severe heart failure.
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