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Targeting inflammation-immune response as a novel strategy for the treatment of brain infarction

Research Project

Project/Area Number 23591262
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionFukuoka Dental College

Principal Investigator

OOBOSHI Hiroaki  福岡歯科大学, 歯学部, 教授 (10311838)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords脳梗塞 / TLR / DAMPs / Peroxiredoxin / マクロファージ / インターロイキン23 / インターロイキン17 / γδT細胞 / peroxiredoxin / 脳虚血 / 炎症 / 自然免疫 / 遺伝子治療 / 免疫 / 遺伝子導入 / T細胞 / インターロイキン
Research Abstract

Immune responses following stroke continue to be an active area of investigation. Prior work has shown that lymphocytes lead to worsened outcome. However, the role of T lymphocyte subtypes has not been well studied. We have recently reported that the gamma-deltaT cells can produce IL-17 following stimulation by macrophage derived IL-23. These cytokines appear to contribute negatively to stroke evolution, as mice deficient in these cytokines are protected. In this study, peroxiredoxin (Prx), an endogenous antioxidant, was identified as a danger signal. Prx is shown to induce IL-23 and leads to worsened stroke outcome through toll-like receptors-2 and -4 pathway. These findings show that Prx is a novel damage-associated molecular patterns (DAMPs) and inhibiting Prx appears to be protective.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (52 results)

All 2014 2013 2012 2011

All Journal Article (25 results) (of which Peer Reviewed: 25 results,  Open Access: 1 results) Presentation (23 results) (of which Invited: 2 results) Book (4 results)

  • [Journal Article] Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia2014

    • Author(s)
      Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma S100A12 is associated with functional outcome after ischemic stroke : Research for Biomarkers in Ischemic Stroke2014

    • Author(s)
      Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators
    • Journal Title

      J Neurol Sci

      Volume: 340 Pages: 75-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack2014

    • Author(s)
      Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; Fukuoka Stroke Registry Investigators (Ooboshi H)
    • Journal Title

      Stroke

      Volume: 45 Pages: 418-25

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High blood pressure after acute ischemic stroke is associated with poor clinical outcomes : Fukuoka Stroke Registry2014

    • Author(s)
      Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators (Ooboshi H)
    • Journal Title

      Hypertension

      Volume: 63 Pages: 54-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] High blood pressure after acute ischemic stroke is associated with poor clinical outcomes: Fukuoka Stroke Registry.2014

    • Author(s)
      Ishitsuka K, Kamouchi M, Hata J, Fukuda K, Matsuo R, Kuroda J, Ago T, Kuwashiro T, Sugimori H, Nakane H, Kitazono T; FSR Investigators (Ooboshi H)
    • Journal Title

      Hypertension

      Volume: 63 Issue: 1 Pages: 54-60

    • DOI

      10.1161/hypertensionaha.113.02189

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ABCD3 and ABCD3-I scores are superior to ABCD2 score in the prediction of short- and long-term risks of stroke after transient ischemic attack.2014

    • Author(s)
      Kiyohara T, Kamouchi M, Kumai Y, Ninomiya T, Hata J, Yoshimura S, Ago T, Okada Y, Kitazono T; Fukuoka Stroke Registry Investigators (Ooboshi H).
    • Journal Title

      Stroke

      Volume: 45 Issue: 2 Pages: 418-25

    • DOI

      10.1161/strokeaha.113.003077

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke.2014

    • Author(s)
      Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T; REBIOS Investigators.
    • Journal Title

      J Neurol Sci

      Volume: 340 Issue: 1-2 Pages: 75-9

    • DOI

      10.1016/j.jns.2014.02.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia.2014

    • Author(s)
      Yamada S, Tokumoto M, Tatsumoto N, Taniguchi M, Noguchi H, Nakano T, Masutani K, Ooboshi H, Tsuruya K, Kitazono T
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotection after cerebral ischemia2013

    • Author(s)
      Namura S, Ooboshi H, Liu J, Yenari MA
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1278 Pages: 25-32

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IT network establishment for neuropatients2013

    • Author(s)
      Abe K, Uchiyama S, Matsubara E, Muramatsu S, Atsuta N, Kitagawa K, Iguchi Y, Ooboshi H, Kaji R, Terao Y
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 53 Pages: 1155-8

    • NAID

      130004505370

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters.2013

    • Author(s)
      Yamada S, Tokumoto M, Ohkuma T, Kansui Y, Wakisaka Y, Uchizono Y, Tsuruya K, Kitazono T, Ooboshi H.
    • Journal Title

      Case Rep Med

      Volume: 2013 Pages: 498129-498129

    • DOI

      10.1155/2013/498129

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] IT network establishment for neuropatients.2013

    • Author(s)
      Abe K, Uchiyama S, Matsubara E, Muramatsu S, Atsuta N, Kitagawa K, Iguchi Y, Ooboshi H, Kaji R, Terao Y
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 53 Pages: 1158-8

    • NAID

      130004505370

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotection after cerebral ischemia.2013

    • Author(s)
      Namura S, Ooboshi H, Liu J, Yenari MA.
    • Journal Title

      Ann N Y Acad Sci

      Volume: 1278(1) Issue: 1 Pages: 25-32

    • DOI

      10.1111/nyas.12087

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke2012

    • Author(s)
      Shichita T, Ago T, Kamouchi M, Kitazono T, Yoshimura A, Ooboshi H
    • Journal Title

      J Neurochem

      Volume: 123S2 Pages: 29-38

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012

    • Author(s)
      Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Akira S, Miyake K, Yoshimura A
    • Journal Title

      Nat Med

      Volume: 18 Pages: 911-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor ß signaling in pericytes following ischemic brain injury2012

    • Author(s)
      Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T
    • Journal Title

      Curr Neurovasc Res

      Volume: 9 Pages: 1-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset : the Fukuoka Stroke Registry2012

    • Author(s)
      Kuwashiro T, Sugimori H, Ago T, Kamouchi M, Kitazono T; FSR Investigators (Ooboshi H)
    • Journal Title

      Cerebrovasc Dis

      Volume: 33 Pages: 141-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke.2012

    • Author(s)
      Shichita T, Ago T, Kamouchi M, Kitazono T, Yoshimura A, Ooboshi H.
    • Journal Title

      J Neurochem

      Volume: 123(S2) Pages: 29-38

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain2012

    • Author(s)
      Shichita T
    • Journal Title

      Nature Medicine

      Volume: 18 Issue: 6 Pages: 911-917

    • DOI

      10.1038/nm.2749

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] PDGF receptor ß signaling in pericytes following ischemic brain injury.2012

    • Author(s)
      Arimura K, Ago T, Kamouchi M, Nakamura K, Ishitsuka K, Kuroda J, Sugimori H, Ooboshi H, Sasaki T, Kitazono T
    • Journal Title

      Curr Neurovasc Res

      Volume: 9 Pages: 1-9

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors predisposing to stroke recurrence within one year of non-cardioembolic stroke onset: the Fukuoka Stroke Registry.2012

    • Author(s)
      Kuwashiro T, Sugimori H, Ago T, Kamouchi M, Kitazono T; FSR Investigators.
    • Journal Title

      Cerebrovasc Dis

      Volume: 33 Pages: 141-149

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke : the Fukuoka Stroke Registry2011

    • Author(s)
      Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators (Ooboshi H)
    • Journal Title

      Stroke

      Volume: 42 Pages: 2788-94

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy as a novel pharmaceutical intervention for stroke2011

    • Author(s)
      Ooboshi H
    • Journal Title

      Curr Pharm Des

      Volume: 17 Pages: 424-33

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene therapy as a novel pharmaceutical intervention for stroke.2011

    • Author(s)
      Ooboshi H
    • Journal Title

      Curr Pharm Des

      Volume: 17 Pages: 424-433

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry.2011

    • Author(s)
      Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators.
    • Journal Title

      Stroke

      Volume: 42 Pages: 2788-2794

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Basic fibroblast growth factor after ischemic stroke in diabetic patients - Research for Biomarkers in Ischemic Stroke (REBIOS) -2014

    • Author(s)
      Nakamura K, Ago T, Arimura K, Makihara N, Nishimura A, Matsuo R, Kuroda J, Wakisaka Y, Isomura T, Awano H, Suzuki K, Okada Y, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
    • Organizer
      International Stroke Conference 2014
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-02-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Basic fibroblast growth factor after ischemic stroke in diabetic patients - Research for Biomarkers in Ischemic Stroke (REBIOS) -.2014

    • Author(s)
      Nakamura K, Ago T, Arimura K, Makihara N, Nishimura A, Matsuo R, Kuroda J, Wakisaka Y, Isomura T, Awano H, Suzuki K, Okada Y, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
    • Organizer
      International Stroke Conference 2014
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The expression of pericyte PDGFRβis regulated by basic FGF after ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) -2013

    • Author(s)
      Nakamura K, Arimura K, Ago T, Makihara N, Isomura T, Watabe W, Awano H, Suzuki K, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
    • Organizer
      Neuroscience Meeting 2013
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Phosphate overload induces systemic inflammation, malnutrition, and vascular calcification in uremia2013

    • Author(s)
      Yamada S, Tokumoto M, Taniguchi M, Tsuruya K, Ooboshi H, and Kitazono T
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] The combined therapy with calcitriol and a calcimimetic agent, R568, ameliorates phosphorus-induced calcification with altered expression of SIRT1 and ALP in human vascular smooth muscle cells2013

    • Author(s)
      Tokumoto M, Yamada S, Fujino T, Tsuruya K, Kitazono T, Ooboshi H
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2013-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳梗塞発症後の糖尿病患者におけるbasic FGFの上昇: Research for Biomarkers in Ischemic Stroke (REBIOS)2013

    • Author(s)
      中村晋之、吾郷哲朗、有村公一、牧原典子、粟野秀人、鈴木一夫、清原裕、鴨打正浩、大星博明、北園孝成
    • Organizer
      日本脳循環代謝学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2013-11-01
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 脳梗塞後のS100A12血漿濃度は昨日予後不良と挿管する:Research for Biomarkers in Ischemic Stroke2013

    • Author(s)
      脇坂義信,吾郷哲朗,鴨打正浩,磯村哲,粟野秀人,鈴木一夫,岡田靖,清原裕,大星博明,北園孝成
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Extracellular newly identified receptor for advanced glycation endproducts binding protein (EN-RAGE) predicts the outcome in patients with acute ischemic stroke : Research for Biomarkers in Ischemic Stroke2013

    • Author(s)
      Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Gotoh S, Watanabe W, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T
    • Organizer
      International Stroke Conference 2013
    • Place of Presentation
      Honolulu, USA
    • Year and Date
      2013-02-06
    • Related Report
      2013 Final Research Report
  • [Presentation] The expression of pericyte PDGFRβ is regulated by basic FGF after ischemic stroke - Research for Biomarkers in Ischemic Stroke (REBIOS) -.2013

    • Author(s)
      Nakamura K, Arimura K, Ago T, Makihara N, Isomura T, Watabe W, Awano H, Suzuki K, Kamouchi M, Kiyohara Y, Ooboshi H, Kitazono T
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phosphate overload induces systemic inflammation, malnutrition, and vascular calcification in uremia.2013

    • Author(s)
      Yamada S, Tokumoto M, Taniguchi M, Tsuruya K, Ooboshi H, and Kitazono T
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] The combined therapy with calcitriol and a calcimimetic agent, R568, ameliorates phosphorus-induced calcification with altered expression of SIRT1 and ALP in human vascular smooth muscle cells.2013

    • Author(s)
      Tokumoto M, Yamada S, Fujino T, Tsuruya K, Kitazono T, Ooboshi H
    • Organizer
      ASN Kidney Week 2013
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳梗塞後のS100A12血漿濃度は昨日予後不良と挿管する:Research for Biomarkers in Ischemic Stroke2013

    • Author(s)
      脇坂義信, 吾郷哲朗, 鴨打正浩, 磯村哲, 粟野秀人, 鈴木一夫, 岡田靖, 清原裕, 大星博明, 北園孝成
    • Organizer
      第38回日本脳卒中学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Extracellular newly identified receptor for advanced glycation endproducts binding protein (EN-RAGE) predicts the outcome in patients with acute ischemic stroke: Research for Biomarkers in Ischemic Stroke2013

    • Author(s)
      Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Gotoh S, Watanabe W, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Takanari K
    • Organizer
      Stroke 2013
    • Place of Presentation
      Honolulu
    • Related Report
      2012 Research-status Report
  • [Presentation] Innate immunity as a novel therapeutic target of brain infarction2012

    • Author(s)
      Hiroaki Ooboshi
    • Organizer
      Transpacific Workshop o Stroke
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Immune response as a novel therapeutic target of brain infarction2012

    • Author(s)
      大星博明
    • Organizer
      第44回日本動脈硬化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate immunity as a novel therapeutic target of brain infarction.2012

    • Author(s)
      Hiroaki Ooboshi
    • Organizer
      Transpacific Workshop o Stroke
    • Place of Presentation
      New Orleans
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Immune response as a novel therapeutic target of brain infarction.2012

    • Author(s)
      大星博明
    • Organizer
      第44回日本動脈硬化学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] T細胞と脳虚血後炎症2011

    • Author(s)
      七田崇、大星博明、北園孝成、石井哲郎、黒田和道、三宅健介、審良静男、吉村昭彦
    • Organizer
      第23回日本脳循環代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate immune response as a novel therapeutic target of brain infarction2011

    • Author(s)
      Ooboshi H
    • Organizer
      First Turkish International Stroke Meeting
    • Place of Presentation
      Antalya, Turkey
    • Year and Date
      2011-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] IL-23 production from infiltrating macrophage in the ischemic brain is dependent on TLR signaling pathway2011

    • Author(s)
      Shichita T, Ooboshi H, Takada I, Ishii T, Kuroda K, Miyake K, Yoshimura A
    • Organizer
      XXVth International Symposium on Cerebral Blood Flow and Metabolism (Brain 2011)
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-05-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Innate immune response as a novel therapeutic target of brain infarction.2011

    • Author(s)
      Ooboshi H
    • Organizer
      The First International Turkish Stroke Meeting(招待講演)
    • Place of Presentation
      トルコ共和国、Antalya
    • Related Report
      2011 Research-status Report
  • [Presentation] IL-23 production from infiltrating macrophage in the ischemic brain is dependent on TLR signaling pathway.2011

    • Author(s)
      Shichita T, Ooboshi H, Takada I, Ishii T, Kuroda K, Miyake K, Yoshimura A
    • Organizer
      第25回国際脳循環代謝学会
    • Place of Presentation
      スペイン、Barcelona
    • Related Report
      2011 Research-status Report
  • [Presentation] T細胞と脳虚血後炎症2011

    • Author(s)
      七田崇、大星博明、北園孝成、石井哲郎、黒田和道、三宅健介、審良静男、吉村昭彦
    • Organizer
      第23回日本脳循環代謝学会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Book] 無症候性脳出血とmicrobleeds.脳血管障害の治療最前線2014

    • Author(s)
      大星博明
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] Midkine gene transfer in brain infarction. Chap 13, Midkine : From Embryogenesis to Pathogenesis and Therapy2012

    • Author(s)
      Ooboshi H, Ishikawa E, Takada J, Shichita T, Kumai Y
    • Total Pages
      38
    • Publisher
      Springer Science
    • Related Report
      2013 Final Research Report
  • [Book] Midkine gene transfer in brain infarction. Ch 13, Midkine: From Embryogenesis to Pathogenesis and Therapy2012

    • Author(s)
      Ooboshi H, Ishikawa E, Takada J, Shichita T, Kumai Y.
    • Total Pages
      380
    • Publisher
      Springer Science
    • Related Report
      2012 Research-status Report
  • [Book] Midkine: From Embryogenesis to Pathogenesis and Therapy, in press Springer Science2012

    • Author(s)
      Ooboshi H, Ishikawa E, Takada J, Shichita T, Kumai Y
    • Total Pages
      380
    • Publisher
      Springer Science
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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