| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
Immune responses following stroke continue to be an active area of investigation. Prior work has shown that lymphocytes lead to worsened outcome. However, the role of T lymphocyte subtypes has not been well studied. We have recently reported that the gamma-deltaT cells can produce IL-17 following stimulation by macrophage derived IL-23. These cytokines appear to contribute negatively to stroke evolution, as mice deficient in these cytokines are protected. In this study, peroxiredoxin (Prx), an endogenous antioxidant, was identified as a danger signal. Prx is shown to induce IL-23 and leads to worsened stroke outcome through toll-like receptors-2 and -4 pathway. These findings show that Prx is a novel damage-associated molecular patterns (DAMPs) and inhibiting Prx appears to be protective.
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