| Project/Area Number |
23591266
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
KIKUCHI Akio 東北大学, 大学病院, 助教 (80463785)
|
|---|
| Research Collaborator |
TAKEDA Atsushi 独立行政法人国立病院機構, 仙台西多賀病院, 院長 (70261534)
OKAMURA Nobuyuki 東北大学, 医学系研究科, 准教授 (40361076)
FURUMOTO Shozo 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00375198)
TASHIRO Manabu 東北大学, サイクロトロン・ラジオアイソトープセンター, 教授 (00333477)
FUNAKI Yoshihito 東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (50261491)
|
|---|
| Project Period (FY) |
2011-04-28 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 多系統萎縮症 / パーキンソン病 / PET / [11C]BF-227 / α-シヌクレイン |
|---|
| Outline of Final Research Achievements |
The histopathological hallmark of multiple system atrophy (MSA) is the appearance of glial cytoplasmic inclusions, which are mainly composed of α-synuclein fibrils. We aimed to study whether [11C] 2-(2-[2-dimethylaminothiazol-5-yl]ethenyl)-6-(2-[fluoro]ethoxy) benzoxazole (BF-227) positron emission tomography (PET) can show time-dependent changes of α-synuclein deposits in brain lesions in four MSA with predominant cerebellar ataxia (MSA-C) patients using the Easy Z-Score Imaging System software. [11C]BF-227 PET showed time-dependent increases of tracer uptake in brain lesions such as the subcortical white matter and from frontal to parietal cortex in all four MSA-C patients. We suggest that [11C]BF-227 PET can be used as a surrogate marker of in vivo α-synuclein deposition in MSA-C.
|
