Novel methods to evaluate neuropathic pain by nerve excitability testing

• Project/Area Number: 23591267
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: KUWABARA SATOSHI 千葉大学, 医学(系)研究科(研究院), 教授 (70282481)
• Co-Investigator(Kenkyū-buntansha): MISAWA Sonoko 千葉大学, 大学院医学研究院, 助教 (30375753) ; ITOH Sho-ichi 千葉大学, 大学院医学研究院, 講師 (60376374)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 神経障害性疼痛 / 糖尿病性神経障害 / 軸索興奮性 / 臨床神経生理学 / 慢性疼痛 / 大脳辺縁系 / 国際情報交換 / オーストラリア / 国際情報交流

Research Abstract

Pain-rerlated brain potentials, axonal excitability testing, and brain blood flow measurements were performed in patients with chronic neuropathic pain, and normal controls. Axonal persistent sodium currents were significantly increased in chronic pain patients, and the abnormally increased currents were suppressed by a Sodium channel blocker, mexiletine, associated with pain relief. In some patients with chronic pain, pain-related potentials were increased and blood flow of the limbic system was increased. These findings suggest peripheral generation of pain, and central sensitization, particularly in the linbic system.

Research Products

• [Journal Article] Bortezomib-induced neuropathy: axonal membrane depolarization precedes development of neuropathy (2014)
  • Author(s): Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S S,
  • Journal Title: Clinical Neurophysiology Volume: 125 Issue: 2 Pages: 381-387
  • DOI: 10.1016/j.clinph.2013.07.014
  • Peer Reviewed
• [Journal Article] Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans (2013)
  • Author(s): Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R
  • Journal Title: Clin Neurophysiol. Volume: 124(7) Issue: 7 Pages: 1422-1430
  • DOI: 10.1016/j.clinph.2013.01.006
  • Peer Reviewed
• [Journal Article] Patterns of sensory nerve conduction abnormalities in Fisher syndrome : more predominant involvement of group Ia afferents than skin afferents (2013)
  • Author(s): Sekiguchi Y, Misawa S, Shibuya K, Mitsuma S, Hirano S, Ohmori S, Koga S, Iwai Y, Beppu M, Kuwabara S
  • Journal Title: Clin Neurophysiol Volume: 124(7) Issue: 7 Pages: 1465-9
  • DOI: 10.1016/j.clinph.2013.01.020
  • Peer Reviewed
• [Journal Article] Differences in excitability between median and superficial radial sensory axons (2012)
  • Author(s): Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto Y, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S
  • Journal Title: Clin Neurophysiol Volume: 123 Issue: 7 Pages: 1440-5
  • DOI: 10.1016/j.clinph.2011.11.002
  • Peer Reviewed
• [Journal Article] Antibodies in axonal Guillain-Barre syndrome (2012)
  • Author(s): Noto Y, Misawa S, Kanai K, Kuwabara S, et al.
  • Journal Title: Journal of Neurology, Neurosurgery, and Psychiatry Volume: 83 Issue: 1 Pages: 23-28
  • DOI: 10.1136/jnnp-2011-300309
  • Peer Reviewed
• [Presentation] 神経障害性疼痛の病態評価における小径線維刺激による疼痛関連誘発電位の有用性 (2013)
  • Author(s): 大森茂樹、磯瀬沙希里、三澤園子、渋谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 高知
  • Year and Date: 2013-11-07
• [Presentation] POEMS症候群における神経障害性疼痛:疼痛関連誘発電位検査による検討 (2013)
  • Author(s): 磯瀬沙希里、三澤園子、大森茂樹、澁谷和幹、関口縁、別府美奈子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第39回日本臨床神経生理学会
  • Place of Presentation: 高知
  • Year and Date: 2013-11-07
• [Presentation] 表皮内刺激電極を用いたPOEMS症候群とCIDPにおける小径線維評価の検討 (2013)
  • Author(s): 磯瀬沙希里、三澤園子、大森茂樹、澁谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第54回日本神経学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-30
• [Presentation] 神経障害性疼痛の病態評価における小径線維刺激による疼痛関連誘発電位の有用性 (2013)
  • Author(s): 大森茂樹、磯瀬沙希里、三澤園子、渋谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第50回日本臨床神経生理学会
  • Place of Presentation: 高知
• [Presentation] 表皮内電気刺激による痛覚誘発電位を用いた神経障害性疼痛の病態 (2012)
  • Author(s): 磯瀬沙希里、三澤園子、大森茂樹、金井数明、澁谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、乾幸二、柿木隆、桑原聡
  • Organizer: 第53回日本神経学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-05-23
• [Presentation] 神経伝導研究の現状と展望 (2012)
  • Author(s): 桑原 聡
  • Organizer: 第89回日本生理学会(招待講演)
  • Place of Presentation: 松本