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Novel methods to evaluate neuropathic pain by nerve excitability testing

Research Project

Project/Area Number 23591267
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionChiba University

Principal Investigator

KUWABARA SATOSHI  千葉大学, 医学(系)研究科(研究院), 教授 (70282481)

Co-Investigator(Kenkyū-buntansha) MISAWA Sonoko  千葉大学, 大学院医学研究院, 助教 (30375753)
ITOH Sho-ichi  千葉大学, 大学院医学研究院, 講師 (60376374)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords神経障害性疼痛 / 糖尿病性神経障害 / 軸索興奮性 / 臨床神経生理学 / 慢性疼痛 / 大脳辺縁系 / 国際情報交換 / オーストラリア / 国際情報交流
Research Abstract

Pain-rerlated brain potentials, axonal excitability testing, and brain blood flow measurements were performed in patients with chronic neuropathic pain, and normal controls. Axonal persistent sodium currents were significantly increased in chronic pain patients, and the abnormally increased currents were suppressed by a Sodium channel blocker, mexiletine, associated with pain relief. In some patients with chronic pain, pain-related potentials were increased and blood flow of the limbic system was increased. These findings suggest peripheral generation of pain, and central sensitization, particularly in the linbic system.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] Bortezomib-induced neuropathy: axonal membrane depolarization precedes development of neuropathy2014

    • Author(s)
      Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S S,
    • Journal Title

      Clinical Neurophysiology

      Volume: 125 Issue: 2 Pages: 381-387

    • DOI

      10.1016/j.clinph.2013.07.014

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Somatotopic representation of pain in the primary somatosensory cortex (S1) in humans2013

    • Author(s)
      Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R
    • Journal Title

      Clin Neurophysiol.

      Volume: 124(7) Issue: 7 Pages: 1422-1430

    • DOI

      10.1016/j.clinph.2013.01.006

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Patterns of sensory nerve conduction abnormalities in Fisher syndrome : more predominant involvement of group Ia afferents than skin afferents2013

    • Author(s)
      Sekiguchi Y, Misawa S, Shibuya K, Mitsuma S, Hirano S, Ohmori S, Koga S, Iwai Y, Beppu M, Kuwabara S
    • Journal Title

      Clin Neurophysiol

      Volume: 124(7) Issue: 7 Pages: 1465-9

    • DOI

      10.1016/j.clinph.2013.01.020

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in excitability between median and superficial radial sensory axons2012

    • Author(s)
      Fujimaki Y, Kanai K, Misawa S, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Ohmori S, Noto Y, Kugio Y, Shimizu T, Matsubara S, Lin CS, Kuwabara S
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Issue: 7 Pages: 1440-5

    • DOI

      10.1016/j.clinph.2011.11.002

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Antibodies in axonal Guillain-Barre syndrome2012

    • Author(s)
      Noto Y, Misawa S, Kanai K, Kuwabara S, et al.
    • Journal Title

      Journal of Neurology, Neurosurgery, and Psychiatry

      Volume: 83 Issue: 1 Pages: 23-28

    • DOI

      10.1136/jnnp-2011-300309

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 神経障害性疼痛の病態評価における小径線維刺激による疼痛関連誘発電位の有用性2013

    • Author(s)
      大森茂樹、磯瀬沙希里、三澤園子、渋谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
    • Organizer
      第39回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] POEMS症候群における神経障害性疼痛:疼痛関連誘発電位検査による検討2013

    • Author(s)
      磯瀬沙希里、三澤園子、大森茂樹、澁谷和幹、関口縁、別府美奈子、三津間さつき、岩井雄太、桑原聡
    • Organizer
      第39回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 表皮内刺激電極を用いたPOEMS症候群とCIDPにおける小径線維評価の検討2013

    • Author(s)
      磯瀬沙希里、三澤園子、大森茂樹、澁谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
    • Organizer
      第54回日本神経学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経障害性疼痛の病態評価における小径線維刺激による疼痛関連誘発電位の有用性2013

    • Author(s)
      大森茂樹、磯瀬沙希里、三澤園子、渋谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、岩井雄太、桑原聡
    • Organizer
      第50回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Related Report
      2013 Annual Research Report
  • [Presentation] 表皮内電気刺激による痛覚誘発電位を用いた神経障害性疼痛の病態2012

    • Author(s)
      磯瀬沙希里、三澤園子、大森茂樹、金井数明、澁谷和幹、関口縁、那須彩子、別府美奈子、三津間さつき、乾幸二、柿木隆、桑原聡
    • Organizer
      第53回日本神経学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経伝導研究の現状と展望2012

    • Author(s)
      桑原 聡
    • Organizer
      第89回日本生理学会(招待講演)
    • Place of Presentation
      松本
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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