| Project/Area Number |
23591267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
KUWABARA SATOSHI 千葉大学, 医学(系)研究科(研究院), 教授 (70282481)
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| Co-Investigator(Kenkyū-buntansha) |
MISAWA Sonoko 千葉大学, 大学院医学研究院, 助教 (30375753)
ITOH Sho-ichi 千葉大学, 大学院医学研究院, 講師 (60376374)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 神経障害性疼痛 / 糖尿病性神経障害 / 軸索興奮性 / 臨床神経生理学 / 慢性疼痛 / 大脳辺縁系 / 国際情報交換 / オーストラリア / 国際情報交流 |
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| Research Abstract |
Pain-rerlated brain potentials, axonal excitability testing, and brain blood flow measurements were performed in patients with chronic neuropathic pain, and normal controls. Axonal persistent sodium currents were significantly increased in chronic pain patients, and the abnormally increased currents were suppressed by a Sodium channel blocker, mexiletine, associated with pain relief. In some patients with chronic pain, pain-related potentials were increased and blood flow of the limbic system was increased. These findings suggest peripheral generation of pain, and central sensitization, particularly in the linbic system.
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