Crosstalk of glia and neuron: Broad-band EEG and neuroimaging analysis for epileptic foci

• Project/Area Number: 23591275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Kyoto University
• Principal Investigator: IKEDA akio 京都大学, 医学(系)研究科(研究院), 教授 (90212761)
• Co-Investigator(Kenkyū-buntansha): 宮本 享 京都大学, 医学研究科, 教授 (70239440) ; 松本 理器 京都大学, 医学研究科, 准教授 (00378754) ; 澤本 伸克 京都大学, 医学研究科, 講師 (90397547) ; 松橋 眞生 京都大学, 脳機能総合センター, 准教授 (40456885)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 発作時DC電位 / 高周波数律動 / てんかん焦点 / グリア細胞 / 神経細胞 / 広域周波数帯域脳波 / 広域周波数脳波解析 / てんかん外科 / 神経膠腫 / 高周波律動（HFO) / 難治てんかん / グリオーシス / 広域周波数脳波活動

Research Abstract

Recently it has been suggested that glia could be actively involved in epileptogenicity in addition to pathological firing of neurons (Iked et al, 1997, 1999). It has been thought that ictal DC shifts could reflect sustained depolarization of neurons augmented by glial passive depolarization, but receently active and earlier role of glia for ictal DC shifts has been suggested. High frequency oscillation (HFO) could reflect neural firing activity. We clarified the features of ictal DC shifts and HFO and implicated them closely in generating epileptic seizures. Additionally, it was also suggested that DC shifts and HFO had distinct generating mechanisms. We aimed to apply the results for delineating epileptic foci in each patients and to provide our findings to neuroscience.

Research Products

• [Journal Article] A novel SCN1A mutation at a cytoplasmic loop in intractable juvenile myoclonic epilepsy without febrile seizures : a case report (2014)
  • Author(s): Jingami N, Matsumoto R, Ito H, Ishii A, Ihara Y, Hirose S, Ikeda A, Takahashi R
  • Journal Title: Epil Disord Volume: (in press)
• [Journal Article] Automatic Reference Selection for Quantitative EEG Interpretation: Identification of Diffuse/ Localised Activity and the Active Earlobe Reference, Iterative Detection of the Distribution of EEG Rhythms (2014)
  • Author(s): Bei Wang, Xingyu Wang, Akio Ikeda, Takashi Nagamine, Hiroshi Shibasaki, Masatoshi Nakamura
  • Journal Title: Medical Engineering & Physics. Medical Engineering & Physics Volume: 36 Issue: 1 Pages: 88-95
  • DOI: 10.1016/j.medengphy.2013.10.002
  • Peer Reviewed
• [Journal Article] Automatic interpretation and writing a report of the adult waking electroencephalogram. (2014)
  • Author(s): Shibasaki H, Nakamura M, Sugi T, Nishida S, Nagamine T, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 印刷中 Issue: 6 Pages: 1081-1094
  • DOI: 10.1016/j.clinph.2013.12.114
  • NAID: 120005439556
  • Peer Reviewed
• [Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation. (2014)
  • Author(s): Yamao Y, Matsumoto R, Kunieda T, Arakawa Y, Kobayashi K, Usami K, Shibata S, Kikuchi T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S.
  • Journal Title: Hum Brain Mapp Volume: 印刷中 Issue: 9 Pages: 74-85
  • DOI: 10.1002/hbm.22479
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of seizure foci and genes in the Lgi1L385R/+ mutant rat. (2014)
  • Author(s): Fumoto N, Mashimo T, Masui A, Ishida S, Mizuguchi Y, Minamimoto S, Ikeda A, Takahashi R, Serikawa T, Yukihiro Ohno Y.
  • Journal Title: Neurosci Res Volume: 印刷中 Pages: 69-75
  • DOI: 10.1016/j.neures.2013.12.008
  • Peer Reviewed
• [Journal Article] Persistent, very frequent subclinical seizures could impair memory even after clinical remission in smoldering limbic encephalitis (2014)
  • Author(s): Kanazawa K, Matsumoto R, Shimotake A, Kinoshita M, Otsuka A, Watanabe A, Tanaka K, Takahashi R, Ikeda A
  • Journal Title: Epil Disord Volume: (in press)
• [Journal Article] A novel SCN1A mutation at a cytoplasmic loop in intractable juvenile myoclonic epilepsy without febrile seizures: a case report. (2014)
  • Author(s): Jingami N, Matsumoto, Ito H, Ishii A, Ihara Y, Hirose S, Ikeda A, Takahashi R.
  • Journal Title: Epil Disord Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Persistent, very frequent subclinical seizures could impair memory even after clinical remission in smoldering limbic encephalitis. (2014)
  • Author(s): Kanazawa K, Matsumoto R, Shimotake A, Kinoshita M, Otsuka A, Watanabe A, Tanaka K, Ryosuke Takahashi R, Ikeda A.
  • Journal Title: Epil Disord Volume: 印刷中
  • Peer Reviewed
• [Journal Article] 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを呈し抗グルタミン酸受容体抗体が検出された2例. (2014)
  • Author(s): 戸島麻耶、人見健文、陣上直人、谷岡洸介、山門穂高、松本理器、高橋幸利、池田昭夫、髙橋良輔.
  • Journal Title: 臨床神経学 Volume: 印刷中
  • NAID: 130004678995
  • Peer Reviewed
• [Journal Article] Bereitschaftspotential augmentation by neuro-feedback training in Parkinson's disease. (2013)
  • Author(s): Fumuro T, Matsuhashi M, Mitsueda T, Inouchi M, Hitomi T, Nakagawa T, Matsumoto R, Kawamata J, Inoue H, Mima T, Takahashi R, Ikeda A.
  • Journal Title: Clin Neurophysiol Volume: 124 Issue: 7 Pages: 1388-405
  • DOI: 10.1016/j.clinph.2013.01.026
  • NAID: 120005296134
  • Peer Reviewed
• [Journal Article] Internal structural change in the hippocampus observed on 3-tesla MRI in patients with mesial temporal lobe epilepsy (2013)
  • Author(s): Mitsueda T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H Takahashi R
  • Journal Title: Int Med Volume: 52(Epub) Pages: 877-85
  • NAID: 130003365993
• [Journal Article] Prolonged ictal monoparesis with parietal PLEDs. (2013)
  • Author(s): Murahara T, Kinoshita M, Matsui M, Yamashita K, Ikeda A, Takahashi R.
  • Journal Title: Epi Disord Volume: 15 Issue: 2 Pages: 197-202
  • DOI: 10.1684/epd.2013.0567
  • Peer Reviewed
• [Journal Article] Pre-SMA actively engages in conflict processing in human: a combined study of epicortical ERPs and direct cortical stimulation. (2013)
  • Author(s): Usami, K., Matsumoto, R., Kunieda, T., Shimotake, A., Matsuhashi, M., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
  • Journal Title: Neuropsychologia Volume: 51 Issue: 5 Pages: 1011-1017
  • DOI: 10.1016/j.neuropsychologia.2013.02.002
  • NAID: 120005244967
  • Peer Reviewed
• [Journal Article] Chicken DT40 cell line lacking DJ-1, the gene responsible for familial Parkinson's disease, displays mitochondrial dysfunction. (2013)
  • Author(s): Minakawa EN, Yamakado H, Tanaka A, Uemura K, Takeda S, Takahashi R.
  • Journal Title: Neurosci Res. Volume: 77(4) Issue: 11 Pages: 228-233
  • DOI: 10.1016/j.clinph.2013.05.011
  • Peer Reviewed
• [Journal Article] Higher degree of clinical anticipation in maternal transmission in benign adult familial myoclonus epilepsy in Japan. (2013)
  • Author(s): Hitomi T, Kobayashi K, Jingami N, Nakagawa T Imamura H, Matsumoto R, Kondo T, Chin K, Takahashi R, Ikeda A
  • Journal Title: Epi Disord Volume: 15 Issue: 4 Pages: 428-32
  • DOI: 10.1684/epd.2013.0608
  • Peer Reviewed
• [Journal Article] Long-term seizure outcome following resective surgery for epilepsy : to be or not to be completely cured? (2013)
  • Author(s): Kunieda T, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S
  • Journal Title: Neurol Med Chir Volume: 53(11)(Epub 2013 Oct 21) Pages: 805-13
• [Journal Article] Evaluation of Focus Laterality in Temporal Lobe Epilepsy: A Quantitative Study Comparing Double Inversion-Recovery MR Imaging at 3T with FDG-PET. (2013)
  • Author(s): Morimoto E, Okada T, Kanagaki M, Yamamoto A, Fushimi Y, Matsumoto R, Takaya S, Ikeda A, Kunieda T, Kikuchi T, Paul D, Miyamoto S, Takahashi R, Togashi K.
  • Journal Title: Epilepsia Volume: 54 Issue: 12 Pages: 2174-83
  • DOI: 10.1111/epi.12396
  • Peer Reviewed
• [Journal Article] Faciobrachial dystonic seizureで初発したくすぶり型の抗leucine-rich glioma- inactivated 1 (LGI1)抗体陽性辺縁系脳炎の1例 (2013)
  • Author(s): 中奥由里子、眞木崇州、金澤恭子、松本理器、福山秀直、高橋良輔、池田昭夫
  • Journal Title: 臨床神経学 Volume: 53 Pages: 706-711
  • NAID: 130004505549
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] 急性無菌性髄膜脳炎の経過中に局所性皮質反射性ミオクローヌスを呈し抗グルタミン酸受容体抗体が検出された2例 (2013)
  • Author(s): 戸島麻耶、人見健文、陣上直人、谷岡洸介、山門穂高、松本理器、高橋幸利、池田昭夫、髙橋良輔
  • Journal Title: 臨床神経学 Volume: (印刷中)
  • NAID: 130004678995
• [Journal Article] Internal structural change in the hippocampus observed on 3-tesla MRI in patients with mesial temporal lobe epilepsy. (2013)
  • Author(s): Mitsueda T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H Takahashi R.
  • Journal Title: Int Med Volume: 52 Pages: 877-85
  • NAID: 130003365993
  • Peer Reviewed
• [Journal Article] Long-term seizure outcome following resective surgery for epilepsy: to be or not to be completely cured? (2013)
  • Author(s): Kunieda T, Mikuni N, Shibata S, Inano R, Yamao Y, Kikuchi T, Matsumoto R, Takahashi J, Ikeda A, Fukuyama H, Miyamoto S.
  • Journal Title: Neurol Med Chir Volume: 53 Pages: 805-13
  • Peer Reviewed
• [Journal Article] Faciobrachial dystonic seizureで初発したくすぶり型の抗leucine-rich glioma-inactivated 1 (LGI1)抗体陽性辺縁系脳炎の1例. (2013)
  • Author(s): 中奥由里子、眞木崇州、金澤恭子、松本理器、福山秀直、高橋良輔、池田昭夫.
  • Journal Title: 臨床神経学 Volume: 53 Pages: 706-11
  • NAID: 130004505549
  • Peer Reviewed
• [Journal Article] Internal structural change in the hippocampus using 3 Tesla MRI in mesial temporal lobe epilepsy (2013)
  • Author(s): Mitsueda T, Ikeda A, Sawamoto N, Aso T, Hanakawa T, Kinoshita M, Matsumoto R, Mikuni N, Amano S, Fukuyama H Takahashi R
  • Journal Title: Int Med Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Faciobrachial dystonic seizureで初発したくすぶり型の抗leucine-rich glioma-inactivated 1 (LGI1)抗体陽性辺縁系脳炎の1例 (2013)
  • Author(s): 中奥由里子、眞木崇州、金澤恭子、松本理器、福山秀直、高橋良輔、池田昭夫
  • Journal Title: 臨床神経 Volume: 印刷中
  • NAID: 130004505549
  • Peer Reviewed
• [Journal Article] 脳波からわかる脳の病態と疾患：脳波は局在情報を有する「機能」検索の gold standard (2013)
  • Author(s): 宇佐美清英、池田昭夫
  • Journal Title: 日本精神科病院協会雑誌 特集企画 てんかん医療をめぐる最新情報－包括医療から地域診療ネットワークまで－ Volume: 32 Pages: 37-46
• [Journal Article] てんかんの神経画像 (2013)
  • Author(s): 山尾幸広、國枝武治、菊池隆幸、松橋眞生、澤本伸克、松本理器、岡田知久、宮本享、池田昭夫：てんかんの神経画像、Brain and Nerve（印刷中）2013
  • Journal Title: Brain and Nerve Volume: 印刷中
• [Journal Article] 抗てんかん薬の催奇形性・周産期における管理指針 (2013)
  • Author(s): 池田昭夫
  • Journal Title: 第３１回 The Mt. Fuji Workshop in CVD Proceeding Volume: 印刷中
• [Journal Article] プラクティス・ノート「高齢者の見えにくいてんかん、どう見る？どうケアする？」 (2013)
  • Author(s): 木下真幸子、中野仁、池田昭夫
  • Journal Title: 月刊ナーシング Volume: 33 Pages: 95-97
• [Journal Article] ステップアップ講座、てんかん発作抑制後の薬物療法 (2013)
  • Author(s): 池田昭夫
  • Journal Title: CNS today Volume: 3 Pages: 3-10
• [Journal Article] Temporal Lobe Epilepsy with Amygdala Enlargement: A Morphologic and Functional Study. (2012)
  • Author(s): Takaya S, Ikeda A, Mitsueda-Ono T, Matsumoto R, Inouchi M, Namiki C, Oishi N, Mikuni N, Ishizu K, Takahashi R, Fukuyama H
  • Journal Title: Journal of Neuroimaging Volume: 24 Issue: 1 Pages: 54-62
  • DOI: 10.1111/j.1552-6569.2011.00694.x
  • Peer Reviewed
• [Journal Article] Anterior temporal lobe white matter abnormal signal (ATLAS) as an indicator of seizure focus laterality in temporal lobe epilepsy: comparison of double inversion-recovery, FLAIR and T2W MR imaging (2012)
  • Author(s): Morimoto E, Kanagaki M, Okada T, Yamamoto A, Mori N, Matsumoto R, Ikeda A, Mikuni N, Kunieda T, Paul D, Miyamoto S, Takahashi R, Togashi K
  • Journal Title: Eur Radiol Volume: 23 Issue: 1 Pages: 3-11
  • DOI: 10.1007/s00330-012-2565-4
  • Peer Reviewed
• [Journal Article] Clinical anticipation in Japanese families of benign adult familial myoclonus epilepsy. (2012)
  • Author(s): Hitomi T, Kondo T, Kobayashi K, Matsumoto R, Takahashi R, Ikeda A
  • Journal Title: Epilepsia Volume: 53 Issue: 2
  • DOI: 10.1111/j.1528-1167.2011.03349.x
  • Peer Reviewed
• [Journal Article] Asymmetric bilateral effect of the supplementary motor area proper in the human motor system. (2012)
  • Author(s): Kikuchi, T., Matsumoto, R., Mikuni, N., Yokoyama, Y., Matsumoto, A., Ikeda, A., Fukuyama, H., Miyamoto, S., & Hashimoto, N.
  • Journal Title: Clinical Neurophysiology Volume: 123 Issue: 2 Pages: 324-334
  • DOI: 10.1016/j.clinph.2011.06.011
  • Peer Reviewed
• [Journal Article] Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies (2012)
  • Author(s): Lüders H, Amina S, Baumgartner C, Benbadis S, Bermeo-Ovalle A, Devereaux M, Diehl B, Edwards J, Baca-Vaca GF, Hamer H, Ikeda A, Pestana E, Rosenow F, Shahid A, Steinhoff BJ, Syed T, Tanner A, Tsuji S
  • Journal Title: Epilepsia Volume: 53(3) Issue: 3 Pages: 405-11
  • DOI: 10.1111/j.1528-1167.2011.03376.x
  • Peer Reviewed
• [Journal Article] A rat model for Lgi1-related epilepsies (2012)
  • Author(s): *Baulac S, Ishida S, *Mashimo T, Boillot M, Fumoto N, Kuwa mura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, Leguern E, Takahashi R, Serikawa T
  • Journal Title: Hum Mol Genet Volume: 21(16) Issue: 16 Pages: 3546-57
  • DOI: 10.1093/hmg/dds184
  • NAID: 120005244992
  • Peer Reviewed
• [Journal Article] てんかん性視覚保続発作に内側側頭葉と頭頂葉の関与が示唆された1例 (2012)
  • Author(s): 當間圭一郎、田口敬子、池田昭夫、西中和人、宇高不可思、亀山正邦
  • Journal Title: 臨床神経学 Volume: 52 Pages: 651-5
  • NAID: 130004505288
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] 脳波自動判読システムにおける短時間脳波の自動検出と特徴抽出-優位律動と徐波の検出 (2012)
  • Author(s): 西田茂人、杉剛直、松橋眞生、池田昭夫、長峯隆、柴崎浩、中村政俊
  • Journal Title: 臨床神経生理学 Volume: 41 Pages: 127-33
  • NAID: 130005003315
• [Journal Article] Clinical anticipation in Japanese families of benign adult familial myoclonus epilepsy (2012)
  • Author(s): Hitomi H, Kondo T, Kobayashi K, Matsumoto R, Takahashi R, Ikeda A
  • Journal Title: Epilepsia Volume: 53(2)
  • Peer Reviewed
• [Journal Article] Transient increase in epileptiform discharges after the introduction of nasal continous positive airway pressure in a patient with obstructive sleep apnea and epilepsy (2012)
  • Author(s): Hitomi T, Oga T, Tsuboi T, yoshimura C, Kato T, Ikeda A, Takahashi R, Chin K
  • Journal Title: Int med Volume: 51(17) Pages: 2453-2456
  • Peer Reviewed
• [Journal Article] てんかん性視覚保続発作に内側側頭葉と頭頂葉の関与が示唆された1例 (2012)
  • Author(s): 當間圭一郎、田口敬子、池田昭夫、西中和人、宇高不可思、亀山 正邦
  • Journal Title: 臨床神経 Volume: 52 Pages: 651-655
  • NAID: 130004505288
  • Peer Reviewed
• [Journal Article] 発作時DC電位（ictal DC shift）: 発作時グリア活動の指標？ (2012)
  • Author(s): 金澤恭子、池田昭夫
  • Journal Title: Epilepsy Volume: 6(1) Pages: 27-33
• [Journal Article] 事象関連電位 (2012)
  • Author(s): 宇佐美清英、池田昭夫
  • Journal Title: Cognition and Dementia Volume: 11(2) Pages: 28-34
• [Journal Article] 成人発症てんかんの診断、知っておきたいてんかん診療 (2012)
  • Author(s): 津田玲子、池田昭夫
  • Journal Title: モダンフィジシャン Volume: 32 Pages: 302-308
• [Journal Article] 極少量のマイスタンでも確実に効果が得られる理由、処方箋の裏側 (2012)
  • Author(s): 池田昭夫
  • Journal Title: 日経ドラッグインフォメーション Volume: 18 Pages: 174-174
• [Journal Article] てんかん病態・脳機能とbroad-band EEG、てんかんをめぐって (2012)
  • Author(s): 池田昭夫
  • Journal Title: 日本てんかん学会北海道地方会機関誌 Volume: 30 Pages: 5-16
• [Journal Article] What’s new in myoclonus? (2012)
  • Author(s): 近藤孝之、小林勝哉、池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 30 Pages: 818-821
• [Journal Article] 新規抗てんかん薬の有用性、てんかん治療の最前線のテーマ (2012)
  • Author(s): 下竹昭寛、池田昭夫
  • Journal Title: Medical Science Digest Volume: 38(7) Pages: 296-299
• [Journal Article] 最新のてんかん薬物治療戦略 (2012)
  • Author(s): 山本貴道、長谷川光広、池田昭夫、栗田浩樹
  • Journal Title: Pharama Medica Volume: -
• [Journal Article] てんかん発作症状と脳機能局在：てんかん発作は脳機能局在を明らかにする (2012)
  • Author(s): 池田昭夫
  • Journal Title: ファイザー Volume: -
• [Journal Article] DC脳波、検査から見る神経疾患 (2012)
  • Author(s): 金澤恭子、池田昭夫
  • Journal Title: Clinical Neuroscience Volume: 30(10) Pages: 1195-1197
• [Journal Article] DC脳波 (2012)
  • Author(s): 金澤恭子、池田昭夫
  • Journal Title: 脳 Volume: 21 Pages: 282-285
• [Journal Article] てんかんの診断：病歴、脳波検査、神経画像検査の3基軸 (2012)
  • Author(s): 三枝隆博、池田昭夫
  • Journal Title: メディカルビューポイント Volume: 33(8) Pages: 3-4
• [Journal Article] てんかんの概念と定義、特集てんかん、新しい診断・治療のABC (2012)
  • Author(s): 池田昭夫
  • Journal Title: 74、てんかん 神経５、最新医学 Volume: 別冊 Pages: 21-31
• [Journal Article] 書評、新てんかんテキスト (2012)
  • Author(s): 池田昭夫
  • Journal Title: 週刊医学界新聞 Volume: 2990 Pages: 6-7
• [Journal Article] 書評、てんかん学ハンドブック(第３版) (2012)
  • Author(s): 池田昭夫
  • Journal Title: 週刊医学界新聞 Volume: 2990 Pages: 6-7
• [Journal Article] てんかんのバイオフィードバック療法 (2012)
  • Author(s): 文室知之、木下真幸子、松橋眞生、松本理器、池田昭夫
  • Journal Title: 精神科 Volume: 21 Pages: 150-157
• [Journal Article] てんかん、症状と治療法 (2012)
  • Author(s): 池田昭夫
  • Journal Title: 読売新聞 Volume: 7月15日 Pages: 14-14
• [Journal Article] 高次脳機能イメージングの脳科学への新展開 (2012)
  • Author(s): 松本理器、國枝武治、池田昭夫
  • Journal Title: Brain and Nerve Volume: 64 Pages: 979-991
• [Journal Article] 遺伝性側頭葉てんかんの遺伝子病態と臨床病態の統合的解明 (2012)
  • Author(s): 池田昭夫、川又純、近藤孝之、松本理器、高橋良輔、石田紗恵子、麓直浩、真下知士、芹川忠夫
  • Journal Title: てんかん治療研究振興財団研究年報 Volume: 23 Pages: 73-82
• [Journal Article] 神経内科専門医に紹介すべきてんかん (2012)
  • Author(s): 井内盛遠、池田昭夫
  • Journal Title: てんかんの診断と連携、治療 Volume: 94(10) Pages: 1709-1713
• [Journal Article] てんかんの遺伝子異常と病態生理、今知っておくべきてんかん (2012)
  • Author(s): 近藤孝之、池田昭夫
  • Journal Title: 月刊Mebio Volume: 11 Pages: 18-23
• [Journal Article] Modern technology calls for a modern approach to classification of epileptic seizures and the epilepsies (2012)
  • Author(s): Lueders H, Amina S, Baumgartner C, Benbadis S, Bermeo-Ovalle A, Devereaux M, Diehl B, Edwards J, Baca-Vaca GF, Hamer H, Ikeda A et al
  • Journal Title: Epilepsia Volume: 53(3) Pages: 105-411
• [Journal Article] Parieto-frontal network in humans studied by cortico-cortical evoked potential (2011)
  • Author(s): Matsumoto R, Nair DR, Ikeda A, Fumuro T, Lapresto E, Mikuni N, Bingaman W, Miyamoto S, Fukuyama H, Takahashi R, Najm I, Shibasaki H, Luders HO
  • Journal Title: Hum Brain Mapp. Volume: 33 Issue: 12 Pages: 19-19
  • DOI: 10.1002/hbm.21407
  • NAID: 120005555455
  • Peer Reviewed
• [Journal Article] Increased cortical hyperexcitability and exaggerated myoclonus with aging in benign adult familial myoclonus epilepsy (2011)
  • Author(s): Hitomi T, Ikeda A, Kondo T, Imamura H, Inouchi M, Matsumoto R, Terada K, Kanda M, Matsuhashi M, Nagamine T, Shibasaki H, Takahashi R
  • Journal Title: Mov Disord Volume: 26 Issue: 8 Pages: 1509-1514
  • DOI: 10.1002/mds.23653
  • Peer Reviewed
• [Journal Article] Left anterior temporal cortex actively engages in speech perception : A direct cortical stimulation study (2011)
  • Author(s): Matsumoto R, Imamura H, Inouchi M, Nakagawa T, Yokoyama Y, Matsuhashi M, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A
  • Journal Title: Neuropsychologia Volume: 49 Issue: 5 Pages: 1350-1354
  • DOI: 10.1016/j.neuropsychologia.2011.01.023
  • NAID: 120003039178
  • Peer Reviewed
• [Journal Article] Ictal wideband ECoG : Direct comparison between ictal slow shifts and high frequency oscillations (2011)
  • Author(s): Imamura H, Matsumoto R, Inouchi M, Matsuhashi M, Mikuni N, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Issue: 8 Pages: 1500-1504
  • DOI: 10.1016/j.clinph.2010.12.060
  • Peer Reviewed
• [Journal Article] Amygdalar enlargement in patients with temporal lobe epilepsy (2011)
  • Author(s): Mitsueda-Ono T, Ikeda A, Inouchi M, Takaya S, Matsumoto R, Hanakawa T, Sawamoto N, Mikuni N, Fukuyama H, Takahashi R
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 82 Issue: 6 Pages: 652-657
  • DOI: 10.1136/jnnp.2010.206342
  • Peer Reviewed
• [Journal Article] Decreased cortical excitability in Unverricht-Lundborg disease in the long-term follow-up : A consecutive SEP study (2011)
  • Author(s): Kobayashi K, Matsumoto R, Kondo T, Kawamata J, Hitomi T, Inouchi M, Matsuhashi M, Takahashi R, Ikeda A
  • Journal Title: Clin Neurophysiol Volume: 122 Issue: 8 Pages: 1617-1621
  • DOI: 10.1016/j.clinph.2011.01.039
  • Peer Reviewed
• [Journal Article] Transient myoclonic state with asterixis : primary motor cortex hyperexcitability is correlated with myoclonus (2011)
  • Author(s): Hitomi T, Ikeda A, Inouchi M, Imamura H, Nakagawa T, Fumuro T, Matsumoto R, Takahashi R
  • Journal Title: Int Med Volume: 50(20)(Epub 2011 Oct 15) Pages: 2303-9
  • NAID: 130001087737
• [Journal Article] An automatic spike detection system based on elimination of false positives using the large-area context in the scalp EEG (2011)
  • Author(s): Ji Z、Sugi T、Goto S、Wang X、Ikeda A、Nagamine T、Shibasaki H、Nakamura
  • Journal Title: IEEE Trans Biomed Eng Volume: 58 Issue: 9 Pages: 2477-2488
  • DOI: 10.1109/tbme.2011.2157917
  • Peer Reviewed
• [Journal Article] Automatic interpretation of hyperventilation-induced electroencephalogram constructed in the way of qualified electroencephalographer's visual inspection (2011)
  • Author(s): Zhang X, Wang X, Sugi T, Ikeda A, Nagamine T, Shibasaki H, Nakamura M
  • Journal Title: Med Biol Eng Comput Volume: 49(2) Issue: 2 Pages: 171-80
  • DOI: 10.1007/s11517-010-0688-9
  • Peer Reviewed
• [Journal Article] Rippling is not always electrically silent in rippling muscle disease. (2011)
  • Author(s): Maki T, Matsumoto R, Kohara N, Kondo T, Sun I, Mezaki T, Nishino I, Ikeda A, Takahashi R
  • Journal Title: Muscle Nerve Volume: 43 Issue: 4 Pages: 601-605
  • DOI: 10.1002/mus.21947
  • NAID: 120005587840
  • Peer Reviewed
• [Journal Article] けいれん様不随意運動の発現に基底核の関与が示唆されたconvulsive syncopeの1例 (2011)
  • Author(s): 村原貴史、高屋成利、山口大介、田中智洋、福山秀直、池田昭夫、高橋良輔
  • Journal Title: 臨床神経学 Volume: 51 Pages: 338-344
  • NAID: 10031164016
  • URL: http://www.neurology-jp.org/Journal/index_j.html
• [Journal Article] Transient Myoclonic State with Asterixis: Primary Motor Cortex Hyperexcitability is Correlated with Myoclonus (2011)
  • Author(s): Hitomi T, Ikeda A, Inouchi M, Imamura H, Nakagawa T, Fumuro T, Matsumoto R, Takahashi R
  • Journal Title: Internal Medicine Volume: 50 Issue: 20 Pages: 2303-2309
  • DOI: 10.2169/internalmedicine.50.5590
  • NAID: 130001087737
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Presentation] グリアとてんかん病態発作時DC脳波の発生機構:てんかん焦点のグリアの関与 (2013)
  • Organizer: 第47回日本てんかん学会
  • Place of Presentation: 小倉(シンポジウム1)
  • Year and Date: 2013-10-11
• [Presentation] Movement disorders and epilepsy. The relationship between myoclonus and epilepsy : New insights from, neurophysiological and genetic studies in myoclonus dystonia and familial cortical tremor (2013)
  • Author(s): Ikeda A
  • Organizer: 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney, Australia
  • Invited
• [Presentation] Controversy session : Localization : electrophysiology vs. metabolism. Seizures : EEG and MEG are the best. Controversy session : Localization (2013)
  • Author(s): Ikeda A
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal Canada
  • Invited
• [Presentation] Teaching session, What's new in diagnostics. The new EEG era. Recording and interpreting, DC shifts and ultra-slow activity. Controversy session : Localization (2013)
  • Author(s): Ikeda A
  • Organizer: 30th International Epilepsy Congress
  • Place of Presentation: Montreal Canada
  • Invited
• [Presentation] Invasive EEG Recording to Define Epileptic Zone. Symposium : EEG in Diagnosis of Seizures and Epilepsy (2013)
  • Author(s): Ikeda A
  • Organizer: 5th Asian and Oceanian Congress of Clinical Neurophysiology
  • Place of Presentation: Bali, Indonesia
  • Invited
• [Presentation] グリアとてんかん病態 発作時DC脳波の発生機構：てんかん焦点のグリアの関与. (2013)
  • Author(s): 池田昭夫.
  • Organizer: 第４７回日本てんかん学会
  • Place of Presentation: 福岡県北九州市
  • Invited
• [Presentation] Movement disorders and epilepsy. The relationship between myoclonus and epilepsy: New insights from, neurophysiological and genetic studies in myoclonus dystonia and familial cortical tremor. (2013)
  • Author(s): Ikeda A.
  • Organizer: 17th International Congress of Parkinson’s Disease and Movement Disorders
  • Place of Presentation: Sydney, Australia
  • Invited
• [Presentation] Localization: electrophysiology vs. metabolism. Seizures: EEG and MEG are the best. (2013)
  • Author(s): Ikeda A.
  • Organizer: 30th International Epilepsy Congress, Controversy session
  • Place of Presentation: Montreal, Canada
  • Invited
• [Presentation] What’s new in diagnostics. The new EEG era. Recording and interpreting, DC shifts and ultra-slow activity. (2013)
  • Author(s): Ikeda A.
  • Organizer: 30th International Epilepsy Congress, Controversy session:Localization, Teaching session
  • Place of Presentation: Montreal, Canada
  • Invited
• [Presentation] Invasive EEG Recording to Define Epileptic Zone. Symposium: EEG in Diagnosis of Seizures and Epilepsy. (2013)
  • Author(s): Ikeda A.
  • Organizer: 5th Asian and Oceanian Congress of Clinical Neurophysiology
  • Place of Presentation: Bali, Indonesia
  • Invited
• [Presentation] Wide-band EEG: ictal DC shifts made by glia? Basic and Translational Research in Epilepsy (2012)
  • Author(s): Ikeda A
  • Organizer: Korean Epilepsy Congress 2012, 5th KES-JES symposium,
  • Place of Presentation: Incheon, Korea
  • Invited
• [Presentation] Focal epileptiform pattern and normal variants (2012)
  • Author(s): Ikeda A
  • Organizer: ASEPA-ANZAN in partnership with Malaysian Epilepsy Council, EEG Teaching Course
  • Place of Presentation: Penang, Malaysia
  • Invited
• [Presentation] Normal EEG 1 Awake (2012)
  • Author(s): Ikeda A
  • Organizer: ASEPA-ANZAN in partnership with Malaysian Epilepsy Council, EEG Teaching Course
  • Place of Presentation: Penang, Malaysia
  • Invited
• [Presentation] Wide-band EEG/MEG analysis for epilepsy: An overview, Workshop on MEG Slow and Ultra-slow Frequency Activity in Epilepsy. (2012)
  • Author(s): Ikeda A
  • Organizer: 6th Annual ACMEGS Conference(招待講演)
  • Place of Presentation: San Antonio, USA
• [Presentation] Motor preparation in human cortices: slow cortical potentials by subdural recording, Motor control; planning and inhibition. (2012)
  • Author(s): Ikeda A
  • Organizer: Korea-Japan Joint Symposium(招待講演)
  • Place of Presentation: Seoul, Korea
• [Presentation] Motor preparation in human cortices: slow cortical potentials by subdural recording. (2012)
  • Author(s): Ikeda A
  • Organizer: Biomagnetics Korea 2012(招待講演)
  • Place of Presentation: Daejeon, Korea
• [Presentation] Brain Stimulation & Epilepsy, ASEPA Didactic Lecture (2012)
  • Author(s): Ikeda A
  • Organizer: 9th Asian Oceanian Epilepsy Congress (AOEC)(招待講演)
  • Place of Presentation: Manila, Philippines
• [Presentation] Role of EEG in epilepsy: Intracranial recording (2011)
  • Author(s): Ikeda A
  • Organizer: 5th Yonsei Epilepsy Preceptorship(招待講演)
  • Place of Presentation: Seoul, Korea
• [Presentation] Wide-band EEG, A surrogate marker of epieptogenicity? (2011)
  • Author(s): Ikeda A
  • Organizer: Epilepsy Symposium at Xuan Wu Hospital 10th Anniversary of Comprehensive Epilepsy Center of Beijing (CECB)(招待講演)
  • Place of Presentation: Beijing, China
• [Presentation] Ictal slow (DC) shifts in wide-band EEG era, EEG-Spotlight on Slow Waves, Special Interest Group Meeting
  • Author(s): Ikeda A
  • Organizer: Annual Meeting of American Epilepsy Society
  • Place of Presentation: San Diego, USA
  • Invited
• [Presentation] てんかんの診断と治療の最近の話題（高齢者の発作を含む）
  • Author(s): 池田昭夫
  • Organizer: 滋賀医科大学神経内科夏期セミナー
  • Place of Presentation: 大津，滋賀県
  • Invited
• [Presentation] てんかんの治療ー難治てんかんへの挑戦１、薬物治療（新薬も含めて）
  • Author(s): 池田昭夫
  • Organizer: 第３５回てんかん基礎講座
  • Place of Presentation: 東京
  • Invited
• [Presentation] てんかんの診断から最新の治療まで、知っておきたいてんかんの原則と治療
  • Author(s): 池田昭夫
  • Organizer: 日本医師会生涯教育協力講座セミナー
  • Place of Presentation: 大津、滋賀県
  • Invited
• [Presentation] 抗てんかん薬の催奇形性・周産期における管理指針、シンポジウム３ てんかんを呈しうる合併疾患を持つ女性の妊娠分娩
  • Author(s): 池田昭夫
  • Organizer: 第３1回Mt Fuji Workshop in CVD
  • Place of Presentation: 大阪
  • Invited
• [Presentation] てんかんの定義・分類・診断
  • Author(s): 池田昭夫
  • Organizer: 第１回サマーてんかんセミナー
  • Place of Presentation: 東京
  • Invited
• [Presentation] 「神経内科専門医の立場から」、「てんかんの診断・治療連携」第２部：パネルディスカッション、各診療科の立場からてんかん診療連携を考える
  • Author(s): 池田昭夫
  • Organizer: 第４６回日本てんかん学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] てんかん診療ネットワークの構築「診療ガイドラインの普及と医師のてんかん教育プログラム」
  • Author(s): 池田昭夫
  • Organizer: 第４６回日本てんかん学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Slow shifts の新しい展開
  • Author(s): 池田昭夫、金澤恭子
  • Organizer: 第４６回日本てんかん学会
  • Place of Presentation: 東京
• [Presentation] てんかんの遺伝子診断前後に臨床医は何をなすか？
  • Author(s): 池田昭夫
  • Organizer: 第４６回日本てんかん学会シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] てんかんの臨床からみた認知症との接点
  • Author(s): 池田昭夫
  • Organizer: 第３１回日本認知症学会
  • Place of Presentation: つくば市、茨城県
  • Invited
• [Presentation] ヒトの運動準備電位(Bereitschaftspotential：BP)の発現機構とvolitionとagency
  • Author(s): 池田昭夫
  • Organizer: 第４２回日本臨床神経生理学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] てんかんの診断から最新の治療まで、知っておきたいてんかんの原則と治療
  • Author(s): 池田昭夫
  • Organizer: 日本医師会生涯教育協力講座セミナー
  • Place of Presentation: 兵庫
  • Invited
• [Presentation] 法的脳死判定における脳波測定
  • Author(s): 池田昭夫
  • Organizer: 滋賀県法的脳死判定・脳波測定実践セミナー
  • Place of Presentation: 滋賀県
  • Invited
• [Presentation] てんかん治療の進歩、シンポジウム：てんかん治療の最前線
  • Author(s): 池田昭夫
  • Organizer: 第３０回日本神経治療学会総会
  • Place of Presentation: 北九州
  • Invited
• [Presentation] 脳波判読セミナー、てんかんの脳波アラカルト：正常亜型との違いは？
  • Author(s): 池田昭夫
  • Organizer: 日本神経学会第９７回近畿地区地方会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] てんかん研究の最前線、シンポジウム１５：最新のてんかんの病態と治療
  • Author(s): 池田昭夫
  • Organizer: 第５２回日本神経学会(招待講演)
  • Place of Presentation: 名古屋、名古屋国際会議場
• [Presentation] てんかん発作症状と脳機能局在、てんかん発作は脳機能局在を明らかにする
  • Author(s): 池田昭夫
  • Organizer: 第４５回日本てんかん学会 ランチョンセミナー 6(招待講演)
  • Place of Presentation: 新潟、朱鷺メッセ新潟コンベンションセンター
• [Presentation] 臨床脳波における症例検討
  • Author(s): 池田昭夫
  • Organizer: 第４８回日本臨床神経生理学会 技術講習会 ビデオハンズオン(招待講演)
  • Place of Presentation: 静岡、グランシップ静岡
• [Presentation] 迷走神経刺激療法の現状、神経内科の立場から
  • Author(s): 池田昭夫
  • Organizer: 第４１回日本臨床神経生理学会 シンポジウム２(招待講演)
  • Place of Presentation: 静岡、グランシップ静岡
• [Presentation] 脳波判読入門：脳波の基礎から波形の読み方まで
  • Author(s): 池田昭夫
  • Organizer: 平成２３年度第１６回全国研修会 日本臨床生理検査研究会 特別講演(招待講演)
  • Place of Presentation: 名古屋、名古屋市立大学医学部
• [Presentation] シンポジウム４ てんかん外科と神経科学 Wide-band EEG; Approach to cerebral function and epileptogenicity
  • Author(s): 池田昭夫
  • Organizer: 第３5回日本てんかん外科学会(招待講演)
  • Place of Presentation: 東京、東京カンファランスセンター
• [Presentation] 硬膜下電極からの発作時緩電位と高周波数律動の同時記録の比較
  • Author(s): 金澤 恭子、他
  • Organizer: 第41回日本臨床神経生理学会
  • Place of Presentation: 静岡、グランシップ静岡
• [Book] 症例から学ぶ戦略的てんかん診断・治療 (2014)
  • Author(s): 池田昭夫(編)
  • Publisher: 南山堂、東京
• [Book] てんかん専門医ガイドブック、日本てんかん学会編 (2014)
  • Author(s): 池田昭夫(編集委員)
  • Publisher: 診断と治療社、東京
• [Book] 症例から学ぶ戦略的てんかん診断・治療 (2014)
  • Author(s): 池田昭夫（編）.
  • Total Pages: 271
  • Publisher: 南山堂
• [Book] てんかん、神経疾患、内科処方実践マニュアル (日本臨床内科医会編) (2013)
  • Author(s): 池田昭夫
  • Total Pages: 544
  • Publisher: 日本医学出版
• [Book] てんかん重積の治療、今日の神経疾患治療指針第２版 (2013)
  • Author(s): 松本理器、池田昭夫
  • Total Pages: 1100
  • Publisher: 医学書院
• [Book] 成人脳波検査データの判読時のポイント、検査診断学への展望、野村努、正田孝明編 (2013)
  • Author(s): 三枝隆博、池田昭夫
  • Total Pages: 706
  • Publisher: 南江堂
• [Book] 認知症とてんかん発作を見誤らないために、認知症とてんかん発作の合併を見落とさないために、精神科臨床エキスパートシリーズ、「誤診症例から学ぶ認知症と老年期の精神・神経疾患の鑑別」（朝田隆編） (2013)
  • Author(s): 木下真幸子、池田昭夫
  • Total Pages: 180
  • Publisher: 医学書院
• [Book] 機能性疾患(てんかん、けいれん重積状態、片頭痛）、神経・運動器疾患、わかりやすい内科学（井村裕夫編）第4版.（印刷中） (2013)
  • Author(s): 池田昭夫
  • Publisher: 文光堂
• [Book] 脳波検査、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2012)
  • Author(s): 松本理器、池田昭夫(宇川義一編)
  • Publisher: 中山書店、東京
• [Book] 成人の薬物療法-総論、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2012)
  • Author(s): 小林勝哉、池田昭夫(宇川義一編)
  • Publisher: 中山書店、東京
• [Book] 脳波検査、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 松本理器、池田昭夫
  • Total Pages: 384
  • Publisher: 中山書店
• [Book] 高齢発症てんかん患者診療のポイント、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 木下真幸子、三枝隆博、池田昭夫
  • Total Pages: 384
  • Publisher: 中山書店
• [Book] 成人の薬物療法-総論、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 小林勝哉、池田昭夫
  • Total Pages: 384
  • Publisher: 中山書店
• [Book] 抗てんかん薬治療アルゴリズム、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 三枝隆博、木下真幸子、池田昭夫
  • Total Pages: 384
  • Publisher: 中山書店
• [Book] 進行性ミオクローヌスてんかん（PME）、稀少難治性てんかん診療の手引き（大槻泰介、井上有史、須貝研司、小国弘量、永井利三郎編）分担執筆 (2012)
  • Author(s): 人見健人、池田昭夫
  • Total Pages: 170
  • Publisher: 診断と治療社
• [Book] 高齢発症てんかん患者診療のポイント、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 小林勝哉、池田昭夫
  • Publisher: 中山書店
• [Book] 成人の薬物療法総論、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 木下真幸子、池田昭夫
  • Publisher: 中山書店
• [Book] 抗てんかん薬治療アルゴリズム、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床、宇川義一編 (2012)
  • Author(s): 三枝隆博、池田昭夫
  • Publisher: 中山書店
• [Book] ミオクローヌスの診断と治療 不随意運動の診断と治療（梶龍兒編） (2012)
  • Author(s): 人見健人、寺田清人、池田昭夫
  • Publisher: 分担執筆
• [Book] 高齢発症てんかん患者診療のポイント、てんかんテキストNew Version、アクチュアル脳・神経疾患の臨床 (2011)
  • Author(s): 木下真幸子、三枝隆博、池田昭夫(宇川義一編)
  • Publisher: 中山書店、東京
• [Book] 日本てんかん学会ガイドライン作成委員会報告高齢者のてんかんの診断・手術適応ガイドライン、てんかん研究28: (2011)
  • Author(s): 池田昭夫.日本てんかん学会ガイドライン作成委員会(藤原建樹、池田昭夫、井上有史、亀山茂樹、須貝研司)
• [Book] てんかん重積の治療、今日の神経疾患治療指針第２版 (2011)
  • Author(s): 松本理器、池田昭夫
  • Publisher: 医学書院
• [Book] てんかん治療ガイドライン、高齢発症てんかんの治療
  • Author(s): 宇佐美清英、池田昭夫
  • Publisher: 日本神経治療学会(印刷中)
• [Remarks]
  • URL: http://epilepsy.med.kyoto-u.ac.jp
• [Remarks] てんかん・運動異常生理学講座
  • URL: http://epilepsy.med.kyoto-u.ac.jp
• [Remarks] 京都大学大学院医学研究科脳病態生理学講座臨床神経学(神経内科)神経生理学
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/laboratory/lab_3_5.htm
• [Remarks]
  • URL: http://www.kuhp.kyoto-u.ac.jp/~neurology/index.html