Establishment of diagnostic method of cognitive impairment in amyotrophic lateral sclerosis
| Project/Area Number |
23591284
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Mitsuru 昭和大学, 医学部・内科学講座・神経内科学部門, 教授 (20161375)
KINNO Ryuta 昭和大学, 医学部・内科学講座・神経内科学部門, 講師 (70439397)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋萎縮性側索硬化症 / 前頭側頭型認知症 / 病態失認 / 書字障害 / 前頭側頭葉変性症 / 病識欠如 |
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| Outline of Final Research Achievements |
Although amyotrophic lateral sclerosis (ALS) sometimes accompanies frontotemporal dementia, it is not easy to estimate cognitive impairment clearly. In this study, self-rating scale for anosognosia and evaluation of writing errors were found important to detect subclinical stage of dementia. As regard to writing, double dissociation between kana and kanji in writing was observed; errors of kana were predominated in general, but errors of kanji were predominated in some cases. Although progression of brain atrophy was different across patients, distribution and progression rate of frontotemporal atrophy were associated with the above clinical characteristics.
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Report
(5 results)
Research Products
(9 results)
