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Establishment of diagnostic method of cognitive impairment in amyotrophic lateral sclerosis

Research Project

Project/Area Number 23591284
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionShowa University

Principal Investigator

HIROO Ichikawa  昭和大学, 医学部, 准教授 (70296953)

Co-Investigator(Kenkyū-buntansha) KAWAMURA Mitsuru  昭和大学, 医学部・内科学講座・神経内科学部門, 教授 (20161375)
KINNO Ryuta  昭和大学, 医学部・内科学講座・神経内科学部門, 講師 (70439397)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords筋萎縮性側索硬化症 / 前頭側頭型認知症 / 病態失認 / 書字障害 / 前頭側頭葉変性症 / 病識欠如
Outline of Final Research Achievements

Although amyotrophic lateral sclerosis (ALS) sometimes accompanies frontotemporal dementia, it is not easy to estimate cognitive impairment clearly. In this study, self-rating scale for anosognosia and evaluation of writing errors were found important to detect subclinical stage of dementia. As regard to writing, double dissociation between kana and kanji in writing was observed; errors of kana were predominated in general, but errors of kanji were predominated in some cases.  Although progression of brain atrophy was different across patients, distribution and progression rate of frontotemporal atrophy were associated with the above clinical characteristics.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Self-rated anosognosia score may be a sensitive and predictive indicator for progressive brain atrophy in amyotrophic lateral sclerosis: An x-ray computed tomographic study.2013

    • Author(s)
      Ichikawa H, Ohno H, Murakami H, Ishigaki S, Ohnaka Y, Kawamura M
    • Journal Title

      European Neurology

      Volume: 69 Issue: 3 Pages: 158-165

    • DOI

      10.1159/000345371

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 筋萎縮性側索硬化症に合併する認知症の早期診断(シンポジウム)2014

    • Author(s)
      市川博雄
    • Organizer
      第32回日本神経治療学会総会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症に合併する前頭側頭型認知症の病像と書字障害:仮名・漢字での相違2014

    • Author(s)
      市川博雄,岩波弘明,板谷一宏,大中洋平,清水裕樹,神谷雄己,杉江正行,河村 満
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡国際センター(福岡市)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における書字障害は進行性脳萎縮の早期徴候か?2011

    • Author(s)
      市川博雄
    • Organizer
      日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)/運動ニューロン病(MND)と言語障害2011

    • Author(s)
      市川博雄
    • Organizer
      日本神経心理学会総会(招待講演)
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における病識欠如と脳萎縮:自己評価票を用いた検討

    • Author(s)
      市川博雄,板谷一宏,大中洋平,清水裕樹,正木久嗣,杉江正行,神谷雄己,河村 満
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症(ALS)における病識欠如と進行性脳萎縮.

    • Author(s)
      市川博雄,清水裕樹,杉江正行,正木久嗣,神谷雄己,村上秀友,河村 満
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 進行性失語における臨床的特徴-失書の問題を中心に-.

    • Author(s)
      市川博雄
    • Organizer
      第36回日本高次脳機能障害学会学術総会
    • Place of Presentation
      栃木県総合文化センター(栃木県)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] すべてがわかるALS(筋萎縮性側索硬化症)・運動ニューロン疾患2013

    • Author(s)
      市川博雄,河村 満
    • Total Pages
      384
    • Publisher
      中山書店
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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