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Development and Clinical application of the Clustering Index method, a new quantitative analysis of surface EMG

Research Project

Project/Area Number 23591285
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionTeikyo University

Principal Investigator

SONOO Masahiro  帝京大学, 医学部, 教授 (40231386)

Co-Investigator(Renkei-kenkyūsha) HIGASHIHARA Mana  東京都健康長寿医療センター, 神経内科, 医師 (20622476)
KUROKAWA Katsumi  川崎医科大学, 医学部神経内科, 准教授 (20289177)
HATANAKA Yuki  帝京大学, 医学部神経内科, 助教 (40322458)
OGAWA Go  帝京大学, 医学部神経内科, 助教 (50632311)
HOKKOKU Keiichi  帝京大学, 医学部神経内科, 助手 (80623355)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords表面筋電図 / 針筋電図 / 神経筋疾患 / 小児 / 定量解析 / Clustering Index法 / 運動単位数推定(MUNE) / 球脊髄性筋萎縮症 / 神経伝導検査 / 筋電図定量解析 / MUNE
Research Abstract

Needle EMG is widely used as a diagnostic measure of neuromuscular disorders, although significant pain is its definite drawback. We developed a quantitative analysis of the surface EMG (SEMG), Clustering Index (CI) method, which can differentiate between neurogenic and myopathic changes by a non-invasive single-channel SEMG recording. In this study, we refined parameters of the CI method that can achieve best diagnostic yield. Furthermore, we examined 27 children having neuromuscular disorders and found that CI method had moderate diagnostic power even for such pediatric patients. We also experienced a patient who had been long diagnosed as muscular dystrophy, although SEMG of the trapezius muscle revealed a neurogenic change, which lead to documentation of the spinal muscular atrophy by gene analysis. SEMG using CI method is a promising non-invasive measure to evaluate neuromuscular disorders.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 17 results) Presentation (22 results) (of which Invited: 3 results)

  • [Journal Article] A new pitfall in a sensory conduction study of the lateral antebrachial cutaneous nerve: Spread to the radial nerve2014

    • Author(s)
      Oishi C, Sonoo M, Kurono H, Hatanaka Y, Shimizu T, Chiba A, et al.
    • Journal Title

      Muscle Nerve

      Volume: 50 Issue: 2 Pages: 186

    • DOI

      10.1002/mus.24129

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Can palm stimulation differentiate diabetic polyneuropathy from carpal tunnel syndrome?2014

    • Author(s)
      Ito E, Sonoo M, Iwanami T, Shimizu T, Iwata M
    • Journal Title

      J Clin Neurophysiol

      Volume: 31 Issue: 2 Pages: 169

    • DOI

      10.1097/wnp.0000000000000036

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of surface MUPs in hypothenar motor unit number estimation2013

    • Author(s)
      Kawamura Y, Sonoo M, Higashihara M, et al.
    • Journal Title

      Muscle Nerve

      Volume: 48 Pages: 185-190

    • Related Report
      2013 Final Research Report
  • [Journal Article] Far-field potentials in hypothenar motor unit number estimation2013

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, et al.
    • Journal Title

      Muscle Nerve

      Volume: 48 Pages: 191-197

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stimulus duration and pain in nerve conduction studies2013

    • Author(s)
      Tamura A, Sonoo M, Hoshino S, et al.
    • Journal Title

      Muscle Nerve

      Volume: 47 Pages: 12-16

    • Related Report
      2013 Final Research Report
  • [Journal Article] A new maneuver for repetitive nerve stimulation testing in the trapezius muscle2013

    • Author(s)
      Ogawa G, Sonoo M, Hatanaka Y, Kaida K, Kamakura K.
    • Journal Title

      Muscle Nerve

      Volume: 47 Issue: 5 Pages: 668

    • DOI

      10.1002/mus.23664

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Far-field potentials in hypothenar motor unit number estimation2013

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, Kawamura Y, Nagashima Y, Terao Y, Kaida K, Kimura F, Ugawa Y, Tsuji S.
    • Journal Title

      Muscle Nerve.

      Volume: 48 Issue: 2 Pages: 191

    • DOI

      10.1002/mus.23734

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of surface motor unit potentials in hypothenar motor unit number estimation2013

    • Author(s)
      Kawamura Y, Sonoo M, Higashihara M, Chiba T, Hatanaka Y.
    • Journal Title

      Muscle Nerve

      Volume: 48 Issue: 2 Pages: 185

    • DOI

      10.1002/mus.23746

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulus duration and pain in nerve conduction studies.2013

    • Author(s)
      Tamura A, Sonoo M, Hoshino S, et al.
    • Journal Title

      Muscle Nerve

      Volume: 47 Pages: 12-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Far-field potentials in hypothenar motor unit number estimation.2013

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, et al.
    • Journal Title

      Muscle Nerve

      Volume: 47

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Origin of surface MUPs in hypothenar motor unit number estimation.2013

    • Author(s)
      Kawamura Y, Sonoo M, Higashihara M, et al.
    • Journal Title

      Muscle Nerve

      Volume: 47

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new maneuver for repetitive nerve stimulation test in the trapezius muscle.2013

    • Author(s)
      Ogawa G, Sonoo M, Hatanaka Y, et al.
    • Journal Title

      Muscle Nerve

      Volume: 47

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] EMGs of the flexor digitorum profundus muscle in inclusion body myositis2012

    • Author(s)
      Hokkoku K, Sonoo M, Higashihara M, et al.
    • Journal Title

      Muscle Nerve

      Volume: 46 Pages: 181-186

    • Related Report
      2013 Final Research Report
  • [Journal Article] Fasciculation potentials in ALS and the diagnostic yield of the Awaji algorithm2012

    • Author(s)
      Higashihara M, Sonoo M, Imafuku I, et al.
    • Journal Title

      Muscle Nerve

      Volume: 45 Pages: 175-182

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] Spread to the dorsal ulnar cutanteous branch: a pitfall during the routine antidromic sensory nerve conduction study of the ulnar nerve.2012

    • Author(s)
      Murashima H, Sonoo M, Tsukamoto H, et al.
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Pages: 973-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A-waves in Guillain-Barré syndrome: correlation with electrophysiological subtypes and antiganglioside antibodies.2012

    • Author(s)
      Kawakami S, Sonoo M, Kadoya A, et al.
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Pages: 1234-41

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] EMGs of the flexor digitorum profundus muscle in inclusion body myositis.2012

    • Author(s)
      Hokkoku K, Sonoo M, Higashihara M, et al.
    • Journal Title

      Muscle Nerve

      Volume: 46 Pages: 181-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reference values for voluntary and stimulated single-fiber EMG using concentric needle electrodes: A multi-center prospective study.2012

    • Author(s)
      Kokubun N, Sonoo M, Imai T, et al
    • Journal Title

      Clin Neurophysiol

      Volume: 123 Pages: 613-620

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of spinal and bulbar muscular atrophy using the Clustering Index method2011

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, et al.
    • Journal Title

      Muscle Nerve

      Volume: 44 Pages: 539-546

    • Related Report
      2013 Final Research Report
  • [Journal Article] Origin of far-field potentials in the ulnar compound muscle action potential2011

    • Author(s)
      Sonoo M, Kurokawa K, Higashihara M, et al.
    • Journal Title

      Muscle Nerve

      Volume: 43 Pages: 671-678

    • Related Report
      2013 Final Research Report
  • [Journal Article] "Clustering index method": a new technique for differentiation between neurogenic and myopathic changes using surface EMG2011

    • Author(s)
      Uesugi H, Sonoo M, Stalberg E, et al
    • Journal Title

      Clin Neurophysiol

      Volume: 122 Pages: 1032-1041

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Origin of far-field potentials in the ulnar compound muscle action potential.2011

    • Author(s)
      Sonoo M, Kurokawa K, Higashihara M, et al
    • Journal Title

      Muscle Nerve

      Volume: 43 Pages: 671-678

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of spinal and bulbar muscular atrophy using the Clustering Index method.2011

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, et al
    • Journal Title

      Muscle Nerve

      Volume: 44 Pages: 539-546

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decremental responses to repetitive nerve stimulation (RNS) in motor neuron disease2011

    • Author(s)
      Iwanami T, Sonoo M, Hatanaka Y, et al
    • Journal Title

      Clin Neurophysiol

      Volume: 122 Pages: 2530-2536

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Invention and clinical application of the Clustering Index (CI) metthod2014

    • Author(s)
      Sonoo M
    • Organizer
      30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
    • Place of Presentation
      Berlin
    • Year and Date
      2014-03-22
    • Related Report
      2013 Final Research Report
  • [Presentation] The most appropriate window width for the"Clustering Index metthod"2014

    • Author(s)
      Uesugi H, Ogawa G, Stalberg E, Higashihara M, Ugawa Y, Hida K, Saito H, Sonoo M
    • Organizer
      30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
    • Place of Presentation
      Berlin
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Far-field potentials reduced the diagnostic sensitivity of hypothenar motor unit number estimation (MUNE) in SBMA patients2013

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, Nagashima Y, Terao Y, Kaida K, Ikewaki K, Ugawa Y, Tsuji S
    • Organizer
      American Academy of Neurology 65th Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2013-03-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Far-field potentials reduced the diagnostic sensitivity of hypothenar motor unit number estimation (MUNE) in SBMA patients.2013

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, et al.
    • Organizer
      American Academy of Neurology 65th Annual Meeting
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Clustering Index method : a quantitative analysis of surface EMG2012

    • Author(s)
      Sonoo M
    • Organizer
      XII Jornada Paulista
    • Place of Presentation
      Sao Paulo
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 定量表面筋電図解析法"Clustering Index法"を用いた、前脛骨筋検査における最適window幅の検討2012

    • Author(s)
      上杉春雄,園生雅弘,東原真奈, Erik Stalberg,斉藤久寿
    • Organizer
      第42回日本臨床神経生理学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-09
    • Related Report
      2013 Final Research Report
  • [Presentation] The most appropriate window width for the"Clustering Index method"2012

    • Author(s)
      Uesugi Y, Sonoo M, Stalberg E, Higashihara M, Ugawa Y, Saito H
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Year and Date
      2012-06-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Surface EMG, Clustering Index2012

    • Author(s)
      Sonoo M, Uesugi H, Higashihara M, Stålberg E
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Year and Date
      2012-06-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Surface EMG, Clustering Index.2012

    • Author(s)
      Sonoo M, Uesugi H, Higashihara M, et al.
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The most appropriate window width for the “Clustering Index method”.2012

    • Author(s)
      Uesugi Y, Sonoo M, Stalberg E, et al.
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
  • [Presentation] Origins of single MUPs in hypothenar MUNE reveal its limitation.2012

    • Author(s)
      Kawamura Y, Sonoo M, Higashihara M, et al.
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
  • [Presentation] Proximal involvement in anti-MAG neuropathy documented using tibial nerve SEPs.2012

    • Author(s)
      Tsukamoto H, Sonoo M, Oishi C, et al.
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
  • [Presentation] Two cases of L5 far-out syndrome confirmed by EMG.2012

    • Author(s)
      Oishi C, Sonoo M, Chiba A.
    • Organizer
      XXth International SFEMG and QEMG Course and XIIth QEMG Conference
    • Place of Presentation
      Istanbul
    • Related Report
      2012 Research-status Report
  • [Presentation] Two cases of L5 far-out syndrome confirmed by electromyography.2012

    • Author(s)
      Oishi C, Sonoo M, Chiba A.
    • Organizer
      59th annual scientific meeting of American association of neuromuscular and electrodiagnostic medicine
    • Place of Presentation
      Orlando
    • Related Report
      2012 Research-status Report
  • [Presentation] Clustering Index method: a quantitative analysis of surface EMG.2012

    • Author(s)
      Sonoo M.
    • Organizer
      XII Jornada Paulista
    • Place of Presentation
      Sao Paolo
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Contribution of far-field potentials on motor unit number estimation2011

    • Author(s)
      Higashihara M, Sonoo M, Yamamoto T, Nagashima Y, Terao Y, Tsuji S, Ugawa Y
    • Organizer
      58th annual scientific meeting of American association of neuromuscular and electrodiagnostic medicine
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of quantitative and qualitative motor unit potential analysis in myopathy.2011

    • Author(s)
      Hokkoku K, Sonoo M, Stalberg E
    • Organizer
      58th annual scientific meeting of American association of neuromuscular and electrodiagnostic medicine
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] Size Index revisited.2011

    • Author(s)
      Sonoo M, Stalberg E
    • Organizer
      58th annual scientific meeting of American association of neuromuscular and electrodiagnostic medicine
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] Initial dip and bilobed N21 peak in the tibial nerve SEPs suggest predominant demyelination of the nerve root.

    • Author(s)
      Chiba T, Sonoo M, Oishi C, Uchino K, Okuma H, Kurono H, Hokkoku K, Hatanaka Y
    • Organizer
      21st Word Congress of Neurology
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2013 Annual Research Report
  • [Presentation] Repetitive nerve stimulation profile in muscle-specific kinase antibody positive myasthenia gravis.

    • Author(s)
      Hokkoku K, Hatanaka Y, Iwanami T, Sonoo M
    • Organizer
      60th annual scientific meeting of American association of neuromuscular and electrodiagnostic medicine
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Invention and clinical application of the Clustering Index (CI) metthod.

    • Author(s)
      Sonoo M
    • Organizer
      30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The most appropriate window width for the “Clustering Index metthod”.

    • Author(s)
      Uesugi H, Ogawa G, Stalberg E, Higashihara M, Ugawa Y, Hida K, Saito H, Sonoo M
    • Organizer
      30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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