A PET study for relation of adenosine receptors with involuntary movements in Parkinson's disease

• Project/Area Number: 23591287
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nippon Medical School
• Principal Investigator: MISHINA Masahiro 日本医科大学, 医学部, 准教授 (70322518)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Masahiko 東京慈恵会医科大学, 医学部, 准教授 (20266638)
• Co-Investigator(Renkei-kenkyūsha): ISHIWATA Kiichi 東京都健康長寿医療センター, 研究所, 研究部長 (50143037) ; ISHII Kenji 東京都健康長寿医療センター, 研究所, 研究副部長 (10231135)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: パーキンソン病 / 安静時振戦 / 固縮 / アデノシンA1受容体 / アデノシンA2A受容体 / ドパミンD2受容体 / ドパミントランスポータ / PET / アデノシン受容体 / ドパミン

Research Abstract

At the dopaminergic synapse, the adenosine A1 receptors (A1Rs) negatively interacts with the dopamine D1 receptor (D1R) in direct pathway neurons and the adenosine A2A receptors (A2ARs) in indirect pathway neurons. The A1R is also found presynaptically, where it is involved in regulation of the dopaminergic system. In addition, the A2AR negatively interacts with the dopamine D2 receptor (D2R) in indirect pathway neurons. The aim of this study was to investigate relationship of striatal density of A1Rs, A2ARs, dopamine transporters (DATs) and D2Rs in resting tremor and rigidity in Parkinson's disease (PD) using positron emission tomography (PET). PET demonstrated significant correlation between the subscores and the density of DATs in the posterior putamen, but not the density of A1Rs, A2ARs and D2Rs. Our study suggested that tremor at rest and rigidity was involved in reduction of DAT in posterior putamen, but not showed the significant relationship with the density of A2AR and D2R.

Research Products

• [Journal Article] 脳の障害に対する可塑性と代償 (2014)
  • Author(s): 三品雅洋
  • Journal Title: 日本医科大学医学会雑誌 Volume: 10
  • NAID: 130004471330
• [Journal Article] 特集脳神経・頭頸部update2013、神経疾患における大脳基底核PETイメージング (2013)
  • Author(s): 三品雅洋
  • Journal Title: 臨床放射線 Volume: Vol 58、No 10 Pages: 1319-1324
• [Journal Article] 特集4 PETによる神経・精神疾患の分子イメージング、パーキンソン病の分子イメージング (2013)
  • Author(s): 三品雅洋
  • Journal Title: PET Journal Volume: No 22(summer) Pages: 44-46
• [Journal Article] 特集 脳神経・頭頸部update2013、神経疾患における大脳基底核PETイメージング (2013)
  • Author(s): 三品雅洋
  • Journal Title: 臨床放射線 Volume: 58 Pages: 1319-1324
• [Journal Article] Differential effects of age on human striatal adenosine A1 and A2A receptors (2012)
  • Author(s): Mishina M, Kimura Y, Naganawa M, Ishii K, Oda K, Sakata M, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K
  • Journal Title: Synapse Volume: 66(9) Pages: 832-839
• [Journal Article] Differential effects of age on human striatal adenosine A1 and A2A receptors (2012)
  • Author(s): Masahiro Mishina, Yuichi Kimura, Mika Naganawa, Kenji Ishii, Keiichi Oda, Muneyuki Sakata, Jun Toyohara, Shiro Kobayashi, Yasuo Katayama, Kiichi Ishiwata
  • Journal Title: Synapse Volume: 66 Issue: 9 Pages: 832-839
  • DOI: 10.1002/syn.21573
  • Peer Reviewed
• [Journal Article] Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson's Disease–A CFT and RAC PET Study (2011)
  • Author(s): Mishina M, Ishii K, Suzuki M, Kitamura S, Ishibashi K, Sakata M, Oda K, Hamamoto M, Kominami S, Kobayashi S, Katayama Y, Ishiwata K
  • Journal Title: The Neuroradiology Journal Volume: 24(2) Pages: 235-241
• [Journal Article] Adenosine A2A Receptors Measured with [^<11>C]TMSX PET in the Striata of Parkinson's Disease Patients (2011)
  • Author(s): Mishina M, Ishiwata K, Naganawa M, Kimura Y, Kitamura S, Suzuki M, Hashimoto M, Ishibashi K, Oda K, Sakata M, Hamamoto M, Kobayashi S, Katayama Y, Ishii K
  • Journal Title: PLoS One Volume: 6:e17338 Pages: 1-8
• [Journal Article] Striatal Distribution of Dopamine Transporters and Dopamine D2 Receptors at Different Stages of Parkinson’s Disease-A CFT and RAC PET Study. (2011)
  • Author(s): M. Mishina, K. Ishii, M. Suzuki, S. Kitamura, K. Ishibashi, M. Sakata, K. Oda, M. Hamamoto, S. Kominami, S. Kobayashi, Y. Katayama, K. Ishiwata.
  • Journal Title: The Neuroradiology Journal Volume: 24 Pages: 235-241
  • Peer Reviewed
• [Presentation] Human brain imaging of Adenosine A1 and A2A receptors (2014)
  • Author(s): Masahiro Mishina
  • Organizer: Purin 2014
  • Place of Presentation: Bonn
  • Invited
• [Presentation] パーキンソン病の振戦・固縮とドパミントランスポータ・ドパミンD2受容体・アデノシンA2A受容体の関係 (2013)
  • Author(s): 三品雅洋、石井賢二、鈴木正彦、橋本昌也、木村裕一、長縄美香、坂田宗之、織田圭一、豊原潤、片山泰朗、石渡喜一
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Relation of striatal density of adenosine A2A receptors, dopamine transporter and dopamine D2 receptor with tremor at rest and rigidity in Parkinson's disease (2013)
  • Author(s): Mishina M, Ishii K, Suzuki M, Nagayama H, Kitamura S, Hashimoto M, Naganawa M, Kimura Y, Sakata M, Oda K, Toyohara J, Katayama Y, Ishiwata K
  • Organizer: The 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney
• [Presentation] 未治療パーキンソン病における被殻アデノシンA1受容体密度 (2013)
  • Author(s): 三品雅洋、石渡喜一、石井賢二、木村裕一、鈴木正彦、橋本昌也、坂田宗之、織田圭一、豊原潤、北村伸、片山泰朗
  • Organizer: 第54回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] Relation of striatal density of adenosine A2A receptors, dopamine transporter and dopamine D2 receptor with tremor at rest and rigidity in Parkinson’s disease (2013)
  • Author(s): Mishina M, Ishii K, Suzuki M, Nagayama H, Kitamura S, Hashimoto M, Naganawa M, Kimura Y, Sakata M, Oda K, Toyohara J, Katayama Y, Ishiwata K
  • Organizer: The 17th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Sydney
• [Presentation] ジスキネジアを呈するパーキンソン病における被殻アデノシンA2A受容体密度—[^<11>C]TMSX PETを用いた検討— (2012)
  • Author(s): 三品雅洋、鈴木正彦、石井賢二、北村伸、長縄美香、木村裕一、橋本昌也、坂田宗之、織田圭一、豊原潤、小林士郎、片山泰朗、石渡喜一
  • Organizer: 第24回日本脳循環代謝学会総会
  • Place of Presentation: 広島
• [Presentation] [^<11>C]MPDX PETを用いた未治療パーキンソン病における被殻アデノシンA1受容体結合能 (2012)
  • Author(s): 三品雅洋、石井賢二、鈴木正彦、北村伸、橋本昌也、木村裕一、坂田宗之、織田圭一、豊原潤、片山泰朗、石渡喜一
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Evaluation of putaminal adenosine A1 receptors in drug naïve Parkinson's disease measured with [^<11>C]MPDX PET (2012)
  • Author(s): Mishina M, Ishii K, Suzuki M, Kitamura S, Hashimoto M, Kimura Y, Sakata M, Oda K, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K
  • Organizer: The 16th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Dublin
• [Presentation] ジスキネジアを呈するパーキンソン病では被殻アデノシンA2A受容体は増加する (2012)
  • Author(s): 三品雅洋、石渡喜一、石井賢二、北村伸、長縄美香、木村裕一、鈴木正彦、橋本昌也、石橋賢士、坂田宗之、織田圭一、豊原潤、濱本真、小林士郎、片山 泰朗
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] Age-related Decrease in Human Extra-striatal Adenosine A1 Receptors Measured with [11C]MPDX PET (2012)
  • Author(s): Masahiro Mishina, Yuichi Kimura, Muneyuki Sakata, Kenji Ishii, Keiichi Oda, Jun Toyohara, Yasuo Katayama, and Kiichi Ishiwata
  • Organizer: Purine 2012: Adenine Nucleosides and Nucleotides in Biomedicine ~ Purinergic Signalling in New Strategy of Drug Discovery ~
  • Place of Presentation: Fukuoka
• [Presentation] Evaluation of putaminal adenosine A1 receptors in drug naïve Parkinson's disease measured with [11C]MPDX PET (2012)
  • Author(s): Mishina M, Ishii K, Suzuki M, Kitamura S, Hashimoto M, Kimura Y, Sakata M, Oda K, Toyohara J, Kobayashi S, Katayama Y, Ishiwata K
  • Organizer: The 16th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Dublin
• [Presentation] 11C]MPDX PETを用いた未治療パーキンソン病における被殻アデノシンA1受容体結合能 (2012)
  • Author(s): 三品雅洋、石井賢二、鈴木正彦、北村伸、橋本昌也、木村裕一、坂田宗之、織田圭一、豊原潤、片山泰朗、石渡喜一
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
• [Presentation] ジスキネジアを呈するパーキンソン病における被殻アデノシンA2A受容体密度―[11C]TMSX PETを用いた検討― (2012)
  • Author(s): 三品雅洋、鈴木正彦、石井賢二、北村伸、長縄美香、木村裕一、橋本昌也、坂田宗之、織田圭一、豊原潤、小林士郎、片山泰朗、石渡喜一
  • Organizer: 第24回日本脳循環代謝学会総会
  • Place of Presentation: 広島
• [Presentation] Age-related changes on adenosine A1 and A2A receptors in human striata measured with PET (2011)
  • Author(s): Mishina M, Ishiwata K, Kimura Y, Naganawa M, Sakata M, Oda K, Toyohara J, Kobayashi S, Katayama Y, and Ishii K.
  • Organizer: Society for Neuroscience’s 41st annual meeting (POSTER)
  • Place of Presentation: Washington DC.
• [Presentation] 被殻アデノシンA1受容体分布の加齢変化－[11C]MPDX PETを用いた検討－ (2011)
  • Author(s): 三品雅洋・石渡喜一・木村裕一・坂田宗之・織田圭一・石井賢二・片山泰朗
  • Organizer: 第23回日本脳循環代謝学会総会
  • Place of Presentation: 東京
• [Presentation] パーキンソン病における被殻ドパミントランスポータ・ドパミンD２受容体分布の病期による変化 (2011)
  • Author(s): 三品雅洋, 石渡喜一, 石井賢二, 北村伸, 鈴木正彦, 橋本昌也, 石橋賢士, 織田圭一, 坂田宗之, 豊原潤, 濱本真, 小林士郎, 片山泰朗
  • Organizer: 第52回日本神経学会総会
  • Place of Presentation: 名古屋
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~mishina/
• [Remarks] Masahiro Mishina, MD, PhD
  • URL: http://plaza.umin.ac.jp/~mishina/
• [Remarks] Masahiro Mishina, MD, PhD
  • URL: http://plaza.umin.ac.jp/~mishina/
• [Remarks]
  • URL: http://plaza.umin.ac.jp/~mishina/