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Development of biomarker and the new therapeutic method for Duchenne muscular dystrophy

Research Project

Project/Area Number 23591290
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionToneyama National Hospital

Principal Investigator

SAITO Toshio  独立行政法人国立病院機構刀根山病院(臨床研究部), その他部局等, 研究員 (60538776)

Co-Investigator(Kenkyū-buntansha) OHIRA Yoshinobu  大阪大学医学(系), 研究科(研究院), 教授 (50185378)
FUJIMURA Harutoshi  国立病院機構, 刀根山病院, 臨床研究部長 (20263246)
MATSUMURA Tsuyoshi  国立病院機構, 刀根山病院 神経内科, 部長 (30549366)
SAKODA Saburo  国立病院機構, 刀根山病院, 院長 (00178625)
Co-Investigator(Renkei-kenkyūsha) SOMA Toshihiro  兵庫医科大学, 血液内科学, 准教授 (40273619)
TAURA Akie  大阪南医療センター, 臨床研究部, 研究員 (80644533)
TADA Satoru  大阪大学, 微生物病研究所, 分子免疫制御分野 (70626530)
YAMADERA Misaki  国立病院機構, 刀根山病院 神経内科, 医員 (90649906)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsDuchenne型筋ジストロフィー / 微小循環障害 / 末梢血血管内皮前駆細胞 / ホスホジエステラーゼ5阻害剤 / 末梢血血管内皮前駆細胞: / ホスホジエステラーゼ5阻害剤 / ジストロフィン異常症 / CD34 / シルデナフィル / NIRS
Research Abstract

In Duchenne muscular dystrophy (DMD), microcirculation abnormalities due to the vascular smooth muscle dysfunction influence the pathomechanism of the disease. The number of the peripheral blood circulation CD34-positive cell counts, which reflects microcirculation abnormalities, shows a higher tendency in low age group of DMD. However, the changes of number of peripheral blood CD34-positive cell counts showed no significant change in the phosphodiesterase 5A inhibitor administration for the purpose of improvement of DMD condition by affecting the microcirculation improvement. It is necessary to evaluate the number of peripheral blood CD34-positive cell counts whether it is useful as the DMD treatment marker.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2014 2013 2012

All Journal Article (1 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Molecular biomarker of angiogenesis in neuromuscular disorders2013

    • Author(s)
      Saito T, Kikuchi-Taura A, Tada S, Iyama A, Kimura N, Matsumura T, Fujimura H, Sakoda S
    • Journal Title

      Neuromuscul Disord

      Volume: 23 Issue: 9-10 Pages: 809-809

    • DOI

      10.1016/j.nmd.2013.06.595

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] A Trial of Sildenafil treatment for patient with Duchenne muscular dystrophy2014

    • Author(s)
      Saito T, Kikuchi-Taura A, Iwata Y, Muneshige E, Yamamoto H, Nishizono H, Matsumura T, Fujimura H, Sakoda S
    • Organizer
      ICNMD 2014 - 13th International Congress on Neuromuscular Diseases
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Duchenne型筋ジストロフィーに対するシルデナフィル投与の試み2014

    • Author(s)
      齊藤利雄,田浦映恵,岩田裕美子,井下兼一郎,宗重絵美,川村佳祐,松村剛,藤村晴俊,佐古田三郎
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      浜松
    • Related Report
      2013 Final Research Report
  • [Presentation] A Trial of Sildenafil treatment for patient with Duchenne muscular dystrophy2014

    • Author(s)
      Toshio Saito
    • Organizer
      13th International Congress on Neuromuscular Diseases
    • Place of Presentation
      Nice, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] Molecular biomarker of angiogenesis in neuromuscular disorders2013

    • Author(s)
      Saito T, Kikuchi-Taura A, Tada S, Iyama A, Kimura N, Matsumura T, Fujimura H, Sakoda S
    • Organizer
      18th World Muscle Society
    • Place of Presentation
      Asilomar conference grounds, Califormia, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経筋疾患の血管新生マーカー2013

    • Author(s)
      齊藤利雄,松村剛
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      大分
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular biomarker of angiogenesis in neuromuscular disorders2013

    • Author(s)
      Toshio Saito
    • Organizer
      18th international congress of the world muscle society
    • Place of Presentation
      Asilomar, California, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経筋疾患の血管新生マーカー2013

    • Author(s)
      齊藤利雄
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      大分市
    • Related Report
      2012 Research-status Report
  • [Presentation] Molecular biomarker of angiogenesis in neuromuscular disorders2013

    • Author(s)
      Toshio Saito
    • Organizer
      18th International World Muscle Society (WMS) Congress
    • Place of Presentation
      Asilomar, California, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 神経筋疾患の血管新生マーカー2012

    • Author(s)
      齊藤利雄,田浦映恵,相馬俊裕,松村剛,猪山昭徳,木村紀久,藤村晴俊,佐古田三郎
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Circulating CD34-positive cells in muscular dystrophy2012

    • Author(s)
      Saito T, Kikuchi-Taura A, Soma T, Iyama A, Kimura N, Matsumura T, Fujimura H, Sakoda S
    • Organizer
      The 11th Annual Asian and Oceanian Myology Center (AOMC) Scientific Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
  • [Presentation] Circulating CD34-positive cells in muscular dystrophy2012

    • Author(s)
      Toshio Saito
    • Organizer
      11th Asian Oceanian Myology Center (AOMC) Scientific Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経筋疾患の血管新生マーカー2012

    • Author(s)
      齊藤利雄
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2011 Research-status Report
  • [Book] Coagulation and fibrinolysis abnormalities in patients with muscular dystrophy. Fibrinolysis and Thrombolysis2014

    • Author(s)
      Saito T
    • Publisher
      Intech
    • Related Report
      2013 Final Research Report
  • [Book] Coagulation and fibrinolysis abnormalities in patients with muscular dystrophy In; Fibrinolysis and Thrombolysis2014

    • Author(s)
      Toshio Saito
    • Total Pages
      195
    • Publisher
      Intech
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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