Short-form GIP; Its Secretion and Glucose homeostasis

• Project/Area Number: 23591291
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Asahikawa Medical College
• Principal Investigator: FUJITA YUKIHIRO 旭川医科大学, 医学部, 助教 (20451461)
• Co-Investigator(Kenkyū-buntansha): HONJO Jun 旭川医科大学, 内科学講座病態代謝内科学分野, 特任助教 (30451462)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: GIP / インクレチン / 膵島 / α細胞 / 糖尿病

Research Abstract

GIP is an incretin hormone, which is released from the gut and involved in homeostasis of glucose metabolism though glucose-depedent insulin secretion from pancreatic beta cells. Interestingly, c-terminal truncated short-form GIP is expressed in pancreatic alpha cells. We found expanded short-from GIP expression in the islet of several diabetic animal models. We synthesized modified short-form GIP and confirmed the peptide to be biologically active by the administration to the normal mice. Finally we treated STZ induced diabetic mice with modified short-form GIP and observed the peptide showed potential to suppress the progression to chronic hyperglycemia in the diabetic model.

Research Products

• [Journal Article] eduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice (2012)
  • Author(s): Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M
  • Journal Title: Diabetologia Volume: 55 Pages: 404-412
• [Journal Article] Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. (2012)
  • Author(s): Takeda Y, Fujita Y, Honjo J, Yanagimachi T, Sakagami H, Takiyama Y, Makino Y, Abiko A, Kieffer TJ, Haneda M.
  • Journal Title: Diabetologia Volume: 55 Issue: 2 Pages: 404-12
  • DOI: 10.1007/s00125-011-2365-4
  • Peer Reviewed
• [Presentation] 持効型short-form GIP投与は低用量STZ誘発糖尿病モデルマウスの耐糖能を改善する (2014)
  • Author(s): 柳町剛司、藤田征弘、本庄潤他
  • Organizer: 日本糖尿病学会第57回年次学術集会
• [Presentation] 持効型short-form GIP投与は低用量STZ誘発糖尿病モデルマウスの耐糖能を改善する (2014)
  • Author(s): 柳町剛司、藤田征弘、本庄潤、他
  • Organizer: 日本糖尿病学会 第５７回年次学術集会
  • Place of Presentation: 大阪
• [Presentation] New Aspect of GIP (2013)
  • Author(s): Yukihiro Fujita
  • Organizer: The 5^<th> AASD Scientific meeting
  • Place of Presentation: Seoul, Korea
• [Presentation] The long-acting analogue of short-form GIP suppress the progression of hyperglycaemia in a streptozotocin -induced diabetic model (2013)
  • Author(s): Tsuyoshi Yanagimachi, Yukihiro Fujita et al.
  • Organizer: World Diabetic Congress (IDF)
  • Place of Presentation: Melbourne, Australia
• [Presentation] The long-acting analogue of short-from GIP suppresses the progression to hyperglycaemia in a streptozotocin-induced diabetic model (2013)
  • Author(s): Yanagimachi T, Fujita Y et al.
  • Organizer: World Diabetes Congress (IDF2013)
  • Place of Presentation: Melbourne, Australia
• [Presentation] New Aspect of GIP (2013)
  • Author(s): Fujita Y
  • Organizer: the 5th AASD Scientific Meeting
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Expression of glucose-dependent imsulinotrophic polypeptide is increased concomitantly with alpha-cell expansion in diabetic models (2012)
  • Author(s): Tsuyoshi Yanagimachi, Yukihiro Fujita et al.
  • Organizer: The 3^<th> AASD & 9^<th> IDF-WPR Scientific meeting
  • Place of Presentation: Kyoto Japan
• [Presentation] (2012)
  • Author(s): 藤田征弘
  • Organizer: 日本糖尿病学会第54回年次学術集会
• [Presentation] 追加発言（シンポジウム インクレチン） (2012)
  • Author(s): 藤田征弘
  • Organizer: 日本糖尿病学会 第54回年次学術集会
  • Place of Presentation: 横浜
  • Invited
• [Presentation] Expression of glucose-dependent imsulinotrophic polypeptide is increased concomitantly with alpha-cell expansion in diabetic models. (2012)
  • Author(s): 柳町剛司、藤田征弘 他
  • Organizer: 3th AASD 9thIDF-WPR
  • Place of Presentation: 京都
• [Presentation] Early DPP-4 inhibition suppresses the progression of diabetes in low-dose STZ mice via alleviation of beta cell death and alpha cell proliferation (2011)
  • Author(s): Yasutaka Takeda, Yukihiro Fujita, Jun Honjo, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Yumi Takiyama, Yuichi Makino, Atsuko Abiko, Masakazu Haneda
  • Organizer: EASD 47th Annual Meeting
  • Place of Presentation: Lisbon, Portugal
• [Presentation] Short-form GIP is expressed in pancreatic alpha cells and gut endocrine cells (2011)
  • Author(s): Yukihiro Fujita
  • Organizer: 2011 International Conference on Diabetes and Metabolism
  • Place of Presentation: Seoul, Korea
• [Presentation] short-from GIPは膵α細胞で発現し、インスリン分泌を促進する (2011)
  • Author(s): 藤田征弘
  • Organizer: 日本糖尿病学会第53回年次学術集会
• [Presentation] short-from GIPは膵α細胞で発現し、インスリン分泌を促進する (2011)
  • Author(s): 藤田征弘
  • Organizer: 日本糖尿病学会 第５３回年次学術集会(招待講演)
  • Place of Presentation: 札幌
• [Presentation] Short-form GIP is expressed in pancreatic alpha cells and gut endocrine cells (2011)
  • Author(s): Yukihiro Fujita
  • Organizer: 2011 International Conference on Diabetes and Metabolism(招待講演)
  • Place of Presentation: Seoul, Korea
• [Presentation] Early DPP-4 inhibition suppresses the progression of diabetes in low-dose STZ mice via alleviation of beta cell death and alpha cell proliferation. (2011)
  • Author(s): Yasutaka Takeda, Yukihiro Fujita, Jun Honjo, Tsuyoshi Yanagimachi, Hiroya Kitsunai, Yumi Takiyama, Yuichi Makino, Atsuko Abiko, Masakazu Haneda
  • Organizer: EASD 47th Annual Meeting
  • Place of Presentation: Lisbon, Portugal