| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We investigated the kinetics of volume density of beta cells by aging and physical status (i.e. obesity) in 115 non-diabetic Japanese subjects. Significant decline of beta cell volume after twenties was identified by neither aging nor physical status. This result indicated that Japanese beta cell had less ability to adapt to various situation than that of western subjects.Furthermore, evaluation of DNA hypermethylation of P16 and progesteron receptor genes in beta cells induced by either aging or type 2 diabetes revealed no hypermetylation. However, small part of the examined subjects exhibited DNA hypermethylation in P16 gene independent of aging or type 2 diabetes. Those subjects also exhibited high proliferation rates of beta cells (>2%). Taken together, aging and physical status do not affect beta cell volume in the case of Japanese subjects. DNA hypermethylation of P16 gene is possibly associated with cell proliferation of beta cells irrespective of diabetic state or aging.
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