| Project/Area Number |
23591297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Chiba University |
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Principal Investigator |
TAKEMOTO Minoru 千葉大学, 医学(系)研究科(研究院), 准教授 (60447307)
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| Co-Investigator(Kenkyū-buntansha) |
YOKOTE Koutaro 千葉大学, 大学院医学研究院, 教授 (20312944)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | Semaphorin3g / 心腎連関 / 糖代謝 / 生活習慣病 / 糖尿病 / 動脈硬化 / 腎臓病 / セマフォリン / α細胞 |
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| Outline of Final Research Achievements |
The purpose of this study was to investigate the mechanism of lifestyle-related diseases, such as glucose dysregulation, atherosclerosis, and kidney diseases, through the functional analysis of Sema3G, with the goal of developing a novel biomarker.
First, we found that Sema3G had a role in sympathetic nerve navigation and correct positioning to the islets of Langerhans. We also found that Sema3G not only had a role in development of atherosclerosis, but also inhibited inflammation within kidney glomeruli. Through our data, we surmise that Sema3G could be an important factor for lifestyle-related diseases through the modulation of glucose dysregulation, atherosclerosis, and kidney diseases.
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