Significance of proteasome dysfunction in the development of obesity-mediated hepatic insulin resistance

• Project/Area Number: 23591301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kanazawa University
• Principal Investigator: TAKAMURA Toshinari 金沢大学, 医学系, 教授 (00324111)
• Co-Investigator(Renkei-kenkyūsha): MURATA Shigeo 東京大学, 薬学研究科(研究院), 教授 (20344070) ; ISEKI Shoichi 金沢大学, 医学系, 教授 (50167251)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: インスリン抵抗性 / 肝臓 / 肥満 / 小胞体ストレス / プロテアソーム / エネルギー / 糖質代謝異常 / 蛋白代謝 / 糖代謝 / 脂質代謝 / insulin resistance / liver / proteasome / ER stress / obesity / type 2 diabetes

Research Abstract

Chronic endoplasmic reticulum (ER) stress is a major contributor to obesity-induced insulin resistance in the liver. Here, we investigated the molecular link between obesity and ER stress. Mouse models of obesity and diabetes and proteasome activator 28 (PA28)-null mice showed 30-40% reduction in proteasome activity and accumulation of poly-ubiquitinated proteins in the liver. PA28-null mice also showed hepatic steatosis, decreased hepatic insulin signaling, and increased hepatic glucose production. The link between proteasome dysfunction and hepatic insulin resistance involves ER stress leading to hyperactivation of c-Jun N-terminal kinase and forkhead box O1 (FoxO1) activation in the liver. Taken together, our data suggest that proteasome dysfunction mediates obesity-induced ER stress, leading to insulin resistance in the liver.

Research Products

• [Journal Article] Remodeling of nutrient homeostasis by unfolded protein response (Commentary) (2014)
  • Author(s): Takamura T
  • Journal Title: Diabetes Volume: 63 Pages: 841-3
  • Peer Reviewed
• [Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance (2014)
  • Author(s): Lan F, Misu H, Chikamoto K, Takayama H, Kikuchi A, Mohri K, Takata N, Hayashi H, Matsuzawa-Nagata N, Takeshita Y, Noda H, Matsumoto Y, Ota T, Nagano T, Nakagen M, Miyamoto KI, Takatsuki K, Seo T, Iwayama K, Tokuyama K, Matsugo S, Tang H, Saito Y, Yamagoe S, Kaneko S, Takamura T
  • Journal Title: Diabetes Volume: 63 Pages: 1649-64
  • NAID: 120005440333
  • Peer Reviewed
• [Journal Article] The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism : a randomised controlled trial (2014)
  • Author(s): Takeshita Y, Takamura T, Honda M, Kita Y, Zen Y, Kato KI, Misu H, Ota T, Nakamura M, Yamada K, Sunagozaka H, Arai K, Yamashita T, Mizukoshi E, Kaneko S
  • Journal Title: Diabetologia Volume: 57 Pages: 878-90
  • Peer Reviewed
• [Journal Article] Metformin Suppresses Expression of the Selenoprotein P Gene via an AMP-activated Kinase (AMPK)/FoxO3a Pathway in H4IIEC3 Hepatocytes (2014)
  • Author(s): Takayama H, Misu H, Iwama H, Chikamoto K, Saito Y, Murao K, Teraguchi A, Lan F, Kikuchi A, Saito R, Tajima N, Shirasaki T, Matsugo S, Miyamoto K, Kaneko S, Takamura T
  • Journal Title: J Biol Chem Volume: 289 Pages: 335-45
  • Peer Reviewed
• [Journal Article] Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic Fatty liver disease (2014)
  • Author(s): Kato K, Takamura T, Takeshita Y, Ryu Y, Misu H, Ota T, Tokuyama K, Nagasaka S, Matsuhisa M, Matsui O, Kaneko S
  • Journal Title: PLOS ONE Volume: 20;9
  • NAID: 120005440398
  • Peer Reviewed
• [Journal Article] Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic Fatty liver disease (2014)
  • Author(s): K Kato, T Takamura, Y Takeshita, Y Ryu, H Misu, T Ota, K Tokuyama, S Nagasaka, M Matsuhisa, O Matsui, S Kaneko
  • Journal Title: PLoS One Volume: 9(3) Issue: 3 Pages: e92170-e92170
  • DOI: 10.1371/journal.pone.0092170
  • NAID: 120005440398
  • Peer Reviewed / Open Access
• [Journal Article] Remodeling of nutrient homeostasis by unfolded protein response. (2014)
  • Author(s): Takamura T
  • Journal Title: Diabetes Volume: 63 Issue: 3 Pages: 841-3
  • DOI: 10.2337/db13-1721
  • NAID: 120005411651
  • Peer Reviewed
• [Journal Article] LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance (2014)
  • Author(s): Fei Lan, H Misu, K Chikamoto, H Takayam, A Kikuchi, K Mohri, N Takata, H Hayashi, N Matsuzawa-Nagata, Y Takeshita, H Noda, Y Matsumoto, T Ota, T Nagano, M Nakagen, K Miyamoto, K Takatsuki, T Seo, K Iwayama, K Tokuyama, S Matsugo, H Tang, Y Saito, S Yamagoe, S Kaneko, T Takamura
  • Journal Title: Diabete Volume: 63 Issue: 5 Pages: 1649-1664
  • DOI: 10.2337/db13-0728
  • Peer Reviewed / Open Access
• [Journal Article] Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes (2014)
  • Author(s): H Takayama, H Misu, H Iwama, K Chikamoto, Y Saito, K Murao, A Teraguchi, F Lan, A Kikuchi, R Saito, N Tajima, T Shirasaki, S Matsugo, KI Miyamoto, S Kaneko, T Takamura
  • Journal Title: J Biol Chem Volume: 289(1) Issue: 1 Pages: 335-45
  • DOI: 10.1074/jbc.m113.479386
  • Peer Reviewed
• [Journal Article] Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver (2013)
  • Author(s): Otoda T, Takamura T, Misu H, Ota T, Murata S, Hayashi H, Takayama H, Kikuchi A, Kanamori T, Shima KR, Lan F, Takeda T, Kurita S, Ishikura K, Kita Y, Iwayama K, Kato KI, Uno M, Takeshita Y, Yamamoto M, Tokuyama K, Iseki S, Tanaka K, Kaneko S
  • Journal Title: Diabetes Volume: 62 Pages: 811-24
  • Peer Reviewed
• [Journal Article] Adipose tissue-derived stem cells as a regenerative therapy for a murine steatohepatitis-induced cirrhosis model (2013)
  • Author(s): Seki A, Sakai Y, Komura T, Nasti A, Yoshida K, Higashimoto M, Honda M, Usui S, Takamura M, Takamura T, Ochiya T, Furuichi K, Wada T, Kaneko S
  • Journal Title: Hepatology Volume: 58 Pages: 1133-42
  • Peer Reviewed
• [Journal Article] Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver (2013)
  • Author(s): T Otoda, T Takamura, H Misu, T Ota, S Murata, H Hayashi, H Takayama, A Kikuchi, T Kanamori, KR Shima, F Lan, T Takeda, S Kurita, K Ishikura, Y Kita, K Iwayama, KI Kato, M Uno, Y Takeshita, M Yamamoto, K Tokuyama, S Iseki, K Tanaka, S Kaneko
  • Journal Title: Diabetes Volume: 62(3) Issue: 3 Pages: 811-24
  • DOI: 10.2337/db11-1652
  • Peer Reviewed
• [Journal Article] Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus (2013)
  • Author(s): Shima T, Uto H, Ueki K, Takamura T, Kohgo Y, Kawata S, Yasui K, Park H, Nakamura N, Nakatou T, Tanaka N, Umemura A, Mizuno M, Tanaka J, Okanoue T
  • Journal Title: J Gastroenterol Volume: 48 Issue: 4 Pages: 515-525
  • DOI: 10.1007/s00535-012-0653-5
  • Peer Reviewed
• [Journal Article] Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis (2013)
  • Author(s): H Ando, T Otoda, H Ookami, Y Nagai, A Inano, T Takamura, K Ushijima, K Hosohata, E Matsushita, T Saito, S Kaneko, A Fujimura
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 40(3) Issue: 3 Pages: 227-32
  • DOI: 10.1111/1440-1681.12055
  • Peer Reviewed
• [Journal Article] Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T (2) correction: phantom and clinical study with histologic assessment. (2013)
  • Author(s): Hayashi N, Miyati T, Minami T, Takeshita Y, Ryu Y, Matsuda T, Ohno N, Hamaguchi T, Kato K, Takamura T, Matsui O.
  • Journal Title: Radiol Phys Technol Volume: 6 Issue: 1 Pages: 219-25
  • DOI: 10.1007/s12194-012-0191-0
  • Peer Reviewed
• [Journal Article] Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men. (2013)
  • Author(s): Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Suwazono Y, Sasaki S, Nakagawa H.
  • Journal Title: Eur J Nutr Volume: [Epub ahead of print]
  • NAID: 120005254069
  • Peer Reviewed
• [Journal Article] Fatty liver as a consequence and cause of insulin resistance : Lessons from type 2 diabetic liver (Review) (2012)
  • Author(s): Takamura T, Misu H, Ota T, Kaneko S
  • Journal Title: Endocr J Volume: 59 Pages: 745-63
  • Peer Reviewed
• [Journal Article] Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes (2012)
  • Author(s): Misu H, Ishikura K, Kurita S, Takeshita Y, Ota T, Saito Y, Takahashi K, Kaneko S, Takamura T
  • Journal Title: PLOS ONE Volume: 7
  • NAID: 120004140847
  • Peer Reviewed
• [Journal Article] Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis (2012)
  • Author(s): Kita Y, Takamura T, Misu H, Ota T, Kurita S, Takeshita Y, Uno M, Matsuzawa-Nagata N, Kato K, Ando H, Fujimura A, Hayashi K, Kimura T, Ni Y, Otoda T, Miyamoto K, Zen Y, Nakanuma Y, Kaneko S
  • Journal Title: PLOS ONE Volume: 7
  • NAID: 120004966626
  • Peer Reviewed
• [Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status (2012)
  • Author(s): H Kitade, K Sawamoto, M Nagashimada, H Inoue, Y Yamamoto, Y Sai, T Takamura, H Yamamoto, K Miyamoto, H N. Ginsberg, N Mukaida, S Kaneko, T Ota
  • Journal Title: Diabetes Volume: 61 Pages: 1680-90
  • Peer Reviewed
• [Journal Article] Identification of blood biomarkers of aging by transcript profiling of whole blood (2012)
  • Author(s): Nakamura S, Kawai K, Takeshita Y, Honda M, Takamura T, Kaneko S, Matoba R, Matsubara K
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Pages: 313-8
  • Peer Reviewed
• [Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status (2012)
  • Author(s): Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, Ota T
  • Journal Title: Diabetes IN PRESS Volume: 61(7) Issue: 7 Pages: 1680-90
  • DOI: 10.2337/db11-1506
  • Peer Reviewed
• [Journal Article] Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes (2012)
  • Author(s): H Misu, K Ishikura, S Kurita, Y Takeshita, T Ota, Y Saito, K Takahashi, S Kaneko, T Takamura
  • Journal Title: PLoS One Volume: 7(4) Issue: 4 Pages: e34952-e34952
  • DOI: 10.1371/journal.pone.0034952
  • NAID: 120004140847
  • Peer Reviewed
• [Journal Article] Synthesis, Structure, and Physiological Effects of Peroxovanadium(V) Complexes Containing Amino Acid Derivatives as Ancillary Ligands. (2012)
  • Author(s): Sugiyama H, Matsugo S, Konish T, Takamura T, Kaneko S, Kubo Y, Sato K, Kanamori K.
  • Journal Title: Chem Lett Volume: 41 Pages: 377-379
  • DOI: 10.1016/j.jinorgbio.2012.12.014
  • NAID: 10030544514
  • Peer Reviewed
• [Journal Article] Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance : Implications for type 2 diabetes. Metabolism (2012)
  • Author(s): Honda M, (他12名, 12番目)
  • Journal Title: Epub ahead of print Volume: (Epub ahead of print) Issue: 10 Pages: 1388-94
  • DOI: 10.1016/j.metabol.2012.03.011
  • Peer Reviewed
• [Journal Article] Self-reported speed of eating and 7-year risk of type 2 diabetes mellitus in middle-aged Japanese men. (2012)
  • Author(s): Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Suwazono Y, Sasaki S, Nakagawa H.
  • Journal Title: Metabolism Volume: 61 Issue: 11 Pages: 1566-71
  • DOI: 10.1016/j.metabol.2012.04.005
  • NAID: 120004997012
  • Peer Reviewed
• [Journal Article] Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia. (2012)
  • Author(s): Kato K, Takeshita Y, Misu H, Ishikura K, Kakinoki K, Kitamura SS, Kaneko S, Takamura T.
  • Journal Title: Endocr J Volume: 59 Pages: 791-6
  • NAID: 10031123122
  • Peer Reviewed
• [Journal Article] Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese. (2012)
  • Author(s): Kawaguchi T
  • Journal Title: PLoS One Volume: 7 Issue: 6 Pages: e38322-e38322
  • DOI: 10.1371/journal.pone.0038322
  • Peer Reviewed
• [Journal Article] Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver (Review). (2012)
  • Author(s): Takamura T, Misu H, Ota T, Kaneko S.
  • Journal Title: Endocr J Volume: 59 Pages: 745-63
  • Peer Reviewed
• [Journal Article] Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis (2012)
  • Author(s): Y Kita, T Takamura, H Misu, T Ota, S Kurita, Y Takeshita, M Uno, N Matsuzawa-Nagata, K Kato, H Ando, A Fujimura, K Hayashi, T Kimura, Y Ni, T Otoda, K Miyamoto, Y Zen, Y Nakanuma, S Kaneko
  • Journal Title: PLoS One Volume: 7(9) Issue: 9 Pages: e43056-e43056
  • DOI: 10.1371/journal.pone.0043056
  • NAID: 120004966626
  • Peer Reviewed
• [Journal Article] Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men. (2012)
  • Author(s): Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Suwazono Ybsaki S, Nakagawa H
  • Journal Title: Metabolism Volume: 61 Issue: 1 Pages: 47-55
  • DOI: 10.1016/j.metabol.2011.05.015
  • NAID: 120003752530
  • Peer Reviewed
• [Journal Article] Identification of blood biomarkers of aging by transcript profiling of whole blood (2012)
  • Author(s): Honda M, (他7名, 4番目)
  • Journal Title: Biochem Biophys Res Commun Volume: 418(2) Issue: 2 Pages: 313-8
  • DOI: 10.1016/j.bbrc.2012.01.018
  • Peer Reviewed
• [Journal Article] Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes (2011)
  • Author(s): Iwakami S, Misu H, Takeda T, Sugimori M, Matsugo S, Kaneko S, Takamura T
  • Journal Title: PLOS ONE Volume: 6
  • Peer Reviewed
• [Journal Article] Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes (2011)
  • Author(s): Nakade Y, Takamura T, Sakurai M, Misu H, Nagata M, Nanbu Y, Oe H, Takamura T, Sakai Y, Kaneko S, Wada T
  • Journal Title: J Diabetes Invest Volume: 2 Issue: 4 Pages: 324-327
  • DOI: 10.1111/j.2040-1124.2010.00098.x
  • NAID: 120005373517
  • Peer Reviewed
• [Journal Article] Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan : Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma (2011)
  • Author(s): Yasui K, Hashimoto E, Komorizono Y, Saibara T
  • Journal Title: Clin Gastroenterol Hepatol Volume: 9 Issue: 5 Pages: 428-433
  • DOI: 10.1016/j.cgh.2011.01.023
  • Peer Reviewed
• [Journal Article] Dose-dependent Dual Effects of Hydrogen Peroxide on Insulin Signal Transduction in H4IIEC Hepatocytes. (2011)
  • Author(s): Iwakami S, Misu H, Takeda T, Sugimori M, Matsugo S, Kaneko S, Takamura T
  • Journal Title: PLoS ONE Volume: 6 Issue: 11 Pages: e27401-e27401
  • DOI: 10.1371/journal.pone.0027401
  • Peer Reviewed
• [Journal Article] Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells
  • Author(s): Ishikura K, Misu H, Kumazaki M, Takayama H,Matsuzawa-Nagata N, Tajima N, Chikamoto K, Lan F, Ando H, Ota T, Sakurai M, Takeshita Y, Kato K, Fujimura A, Miyamoto K, Saito Y, Kameo S, Okamoto Y, Takuwa Y, Takahashi K, Kidoya H, Takakura N, Kaneko S, Takamura T
  • Journal Title: Diabetologia Volume: (in press) (2014予定)
  • Peer Reviewed
• [Presentation] ヘパトカインを介した肝臓-骨格筋連関によるエネルギー代謝調節 (2014)
  • Author(s): 篁俊成
  • Organizer: 第57回日本糖尿病学会年次学術集会、シンポジウム13「インスリン抵抗性の新展開ーアディポサイトカインから慢性炎症までー」
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-23
• [Presentation] 食事療法のサイエンス (2014)
  • Author(s): 篁俊成
  • Organizer: 第48回糖尿病学の進歩、シンポジウム「食事療法と運動療法の科学的側面をさぐる」
  • Place of Presentation: 札幌
  • Year and Date: 2014-03-07
• [Presentation] Organ-specific fat accumulation and insulin resistance among the liver, skeletal muscle and adipose tissue in people with nonalcoholic fatty liver disease (2013)
  • Author(s): Takamura T, Kato K-I, Misu H, Takeshita Y, Kaneko S
  • Organizer: 49th Annual Meeting of the European Association for the Study of Diabetes (EASD)
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2013-09-26
• [Presentation] スローエイジングを目指す血糖制御とその向こうにあるもの (2013)
  • Author(s): 篁俊成
  • Organizer: 日本循環器予防学会
  • Place of Presentation: 金沢(教育講演)
  • Year and Date: 2013-06-15
• [Presentation] 糖尿病医療における食事療法の課題 (2013)
  • Author(s): 篁俊成
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本(シンポジウム)
  • Year and Date: 2013-05-17
• [Presentation] 疫学・臨床・基礎研究を統合して挑む糖尿病医療 (2013)
  • Author(s): 篁俊成
  • Organizer: 第83回日本衛生学会
  • Place of Presentation: 金沢(シンポジウム)
  • Year and Date: 2013-03-24
• [Presentation] 高血糖昏睡の治療.糖尿病学の進歩 (2013)
  • Author(s): 篁俊成
  • Place of Presentation: 四日市市(教育講演)
  • Year and Date: 2013-02-15
• [Presentation] Positioning of vildagliptine vs. liraglutide as a step-up from sitagliptine-based regimens in people with type 2 diabetes : ERA-DM Study Chapter 2 (2012)
  • Author(s): Takamura T
  • Organizer: 9th IDF-WPR Congress and 4th AASD Scientific Meeting(第9回国際糖尿病連合西太平洋地区会議/第4回アジア糖尿病学会学術集会)
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 2012-11-26
• [Presentation] 肝臓における栄養代謝:その基礎と進歩 (2012)
  • Author(s): 篁俊成
  • Organizer: 平成24年度日本肝臓学会前期教育講演会(第48回日本肝臓学会総会)
  • Place of Presentation: 金沢(教育講演)
  • Year and Date: 2012-06-09
• [Presentation] 糖質制限食療法をアートではなくサイエンスとして確立するための課題とロードマップ (2012)
  • Author(s): 篁俊成
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜(シンポジウム)
  • Year and Date: 2012-05-18
• [Presentation] NAFLD : Cause and Consequence of Diabetes (2012)
  • Author(s): 篁俊成
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜(教育講演)
  • Year and Date: 2012-05-18
• [Presentation] ヘパトカインが形成する2型糖尿病の病態 (2012)
  • Author(s): 篁俊成
  • Organizer: 第46回糖尿病学の進歩
  • Place of Presentation: 盛岡(教育講演)
  • Year and Date: 2012-03-03
• [Presentation] Dual effects of ROS and possible reductive stress on insulin signal transduction in hepatocytes (2012)
  • Author(s): Takamura T, Misu H, Kaneko S
  • Organizer: Keystone Symposia- Pathogenesis of Diabetes : Emerging Insights into Molecular Mechanisms
  • Place of Presentation: Santa Fe, New Mexico (USA)
  • Year and Date: 2012-02-02
• [Presentation] 臓器特異的インスリン抵抗性（ＩＲ）指標の妥当性および肝病理像との関連 (2012)
  • Author(s): 加藤健一郎， 竹下有美枝，御簾博文，太田嗣人，徳山薫平，松久宗英，長坂昌一郎，金子周一，篁俊成
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜、横浜、神奈川
• [Presentation] NAFLD : Cause and Consequence of Diabetes (2012)
  • Author(s): 篁 俊成
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: パシフィコ横浜、横浜、神奈川
  • Invited
• [Presentation] 肥満は肝プロテアソーム機能障害を介して小胞体ストレスとインスリン抵抗性を誘導する (2012)
  • Author(s): 乙田敏城， 篁俊成，御簾博文，太田嗣人，金子周一
  • Organizer: 第62回日本体質医学会総会
  • Place of Presentation: 大阪国際会議場、大阪、大阪
• [Presentation] Proteasome dysfunction links obesity and endoplasmic reticulum stress leading to insulin resistance in the liver (2012)
  • Author(s): Toshiki Otoda， Toshinari Takamura, Hirofumi Misu, Tsuguhito Ota, Shuichi Kaneko
  • Organizer: 9th IDF-WPR Congress and 4th AASD Scientific Meeting
  • Place of Presentation: 京都国際会館、Kyoto, Kyoto
• [Presentation] Ectopic fat accumulation and distant organ-specific insulin resistance in people with nonalcoholic fatty liver disease (2012)
  • Author(s): Ken-ichiro Kato， Yumie Takeshita, Hirofumi Misu, Tsuguhito Ota, Kumpei Tokuyama, Soichiro Nagasaka, Munehisa Matsuhisa, Shuichi Kaneko, Toshinari Takamura
  • Organizer: 9th IDF-WPR Congress and 4th AASD Scientific Meeting
  • Place of Presentation: 京都国際会館、Kyoto, Kyoto
• [Presentation] ヘパトカインが形成する2型糖尿病の病態 (2012)
  • Author(s): 篁 俊成
  • Organizer: 第46回糖尿病学の進歩(招待講演)
  • Place of Presentation: 盛岡、盛岡グランドホテル
• [Presentation] Selenoprotein P as a hepatokine that causes insulin resistance (2011)
  • Author(s): Takamura T
  • Organizer: The 2011 International Conference on Diabetes and Metabolism
  • Place of Presentation: Grand Hilton Seoul Hotel, Seoul (Korea)(Lecture)
  • Year and Date: 2011-11-11
• [Presentation] セレノプロテインPによるVEGF抵抗性とメトホルミンによる制御の可能性 (2011)
  • Author(s): 篁俊成
  • Organizer: 第16回アディポサイエンス研究会
  • Place of Presentation: 大阪(講演)
  • Year and Date: 2011-08-20
• [Presentation] 肝臓と糖代謝—Lessons from Type 2 Diabetic Liver (2011)
  • Author(s): 篁俊成、御簾博文、金子周一
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京(講演)
  • Year and Date: 2011-06-02
• [Presentation] スローエイジングを見据えた糖尿病の総合的治療戦略 (2011)
  • Author(s): 篁俊成
  • Organizer: 第50回日本臨床検査医学会東海・北陸支部総会、第322回日本臨床化学会、東海・北陸支部例会連合大会
  • Place of Presentation: 金沢(シンポジウム)
  • Year and Date: 2011-03-13
• [Presentation] スローエイジングを目指す2型糖尿病の全人的ケア (2011)
  • Author(s): 篁俊成
  • Organizer: 第52回日本内科学会北陸支部
  • Place of Presentation: 金沢(生涯教育講演会)
  • Year and Date: 2011-03-13
• [Presentation] 過栄養状態の肝臓が形成する2型糖尿病の病態 (2011)
  • Author(s): 篁俊成
  • Organizer: 第45回糖尿病学の進歩
  • Place of Presentation: 福岡
  • Year and Date: 2011-02-18
• [Presentation] Proteasome dysfunction in obesity contributes to ER stress, enhanced autophagy and insulin resistance in type 2 diabetic liver (2011)
  • Author(s): Toshinari Takamura, Toshiki Otoda, Hirofumi Misu, Tsuguhito Ota, and Shuichi Kaneko
  • Organizer: Keystone Symposia- Type 2 Diabetes, Insulin Resistance and Metabolic Dysfunction
  • Place of Presentation: Keystone, Colorado (USA)
  • Year and Date: 2011-01-15
• [Presentation] 肝臓と糖代謝―Lessons from Type 2 Diabetic Liver (2011)
  • Author(s): 篁 俊成， 金子周一
  • Organizer: 第47回日本肝臓学会総会(招待講演)
  • Place of Presentation: 東京、ホテルグランパシフィック LE DAIBA
• [Presentation] 肥満による肝インスリン抵抗性形成におけるプロテアソーム機能異常の意義． (2011)
  • Author(s): 篁 俊成
  • Organizer: 第5回Diabetes Leading-edge Conference(招待講演)
  • Place of Presentation: 滋賀、ロイヤルオークホテル
• [Presentation] セレノプロテインPによるVEGF抵抗性とメトホルミンによる制御の可能性 (2011)
  • Author(s): 篁 俊成，御簾博文，金子周一
  • Organizer: 第16回アディポサイエンス研究会(招待講演)
  • Place of Presentation: 大阪、千里阪急ホテル
• [Presentation] Selenoprotein P as a hepatokine that causes insulin resistance (2011)
  • Author(s): Takamura T
  • Organizer: The 2011 International Conference on Diabetes and Metabolism(招待講演)
  • Place of Presentation: Seoul (Korea)、Grand Hilton Seoul Hotel
• [Presentation] Organ-specific fat accumulation and insulin resistance among the liver, skeletal muscle and adipose tissue in people with nonalcoholic fatty liver disease.
  • Author(s): Takamura T, Kato K-I, Misu H, Takeshita Y, Kaneko S:
  • Organizer: 49th Annual Meeting of the European Association for the Study of Diabetes (EASD)
  • Place of Presentation: Barcelona(Spain)
• [Presentation] スローエイジングを目指す血糖制御とその向こうにあるもの
  • Author(s): 篁 俊成
  • Organizer: 日本循環器予防学会、教育講演
  • Place of Presentation: 金沢
  • Invited
• [Presentation] 糖尿病医療における食事療法の課題
  • Author(s): 篁 俊成
  • Organizer: 第56回 日本糖尿病学会年次学術集会、シンポジウム
  • Place of Presentation: 熊本
  • Invited
• [Book] 糖尿病 (2014)
  • Author(s): 篁 俊成（分担執筆）
  • Publisher: 西村書店
• [Book] 糖尿病専門医研修ガイドブック改訂第6版 (2014)
  • Author(s): 篁 俊成（分担執筆）
  • Publisher: 診断と治療社
• [Book] Team DiETの糖尿病療養メソッド (2013)
  • Author(s): 篁俊成(編)
  • Total Pages: 133
  • Publisher: 日本医事新報社,東京
• [Book] Team DiETの糖尿病療養メソッド (2013)
  • Author(s): 篁 俊成（編著）
  • Total Pages: 133
  • Publisher: 日本医事新報社
• [Book] 肝臓由来分泌蛋白セレノプロテインPとインスリン抵抗性.In「肝疾患Review 2012-2013」 (2012)
  • Author(s): 篁俊成,金子周一(小俣政男監修、河田純男、横須賀收、工藤正俊、榎本信幸編)
  • Publisher: 日本メディカルセンター,東京
• [Book] 肝臓由来生理活性分子(ヘパトカイン)が形成する2型糖尿病の病態.In糖尿病学の進歩第46集 (2012)
  • Author(s): 篁俊成(日本糖尿病学会編)
  • Publisher: 診断と治療社,東京
• [Book] BMI, waistcircumference and metabolic syndrome : Lessons from Japanese perspectives. In The Handbook of Anthropometry : Physical Measures of Human Form in Health and Disease (2012)
  • Author(s): Sakurai M, Ota T, Miura K, Nakagawa H, Kaneko S, Takamura T (corresponding author).(V.R. Preedy, Eds.)
  • Publisher: Springer Science+Business Media, New York, USA
• [Book] Annual Review 糖尿病・代謝・内分泌 2012（寺内康夫、伊藤 裕、石橋 俊 編） (2012)
  • Author(s): 御簾 博文，篁 俊成
  • Publisher: 中外医学社
• [Book] 糖尿病・肥満症患者における遺伝子発現変化In Annual Review糖尿病・代謝・内分泌2011 (2011)
  • Author(s): 篁俊成(寺内康夫、伊藤裕、石橋俊編)
  • Publisher: 中外医学社,東京
• [Book] Annual Review 糖尿病・代謝・内分泌 2011（寺内康夫、伊藤 裕、石橋 俊 編） (2011)
  • Author(s): 篁 俊成
  • Publisher: 中外医学社
• [Remarks]
  • URL: http://www.m-kanazawa.jp/index.htmlhttps://www.facebook.com/TakamuraLab
• [Remarks] tt Lab-金沢大学 包括的代謝学（糖尿病・内分泌代謝研究室）
  • URL: https://www.facebook.com/TakamuraLab
• [Remarks] 金沢大学恒常性制御学講座
  • URL: http://www.m-kanazawa.jp/research/index.html
• [Remarks] 金沢大学Web広報誌 e-Acanthus
  • URL: http://www.kanazawa-u.ac.jp/university/administration/prstrategy/eacanthus/1212/04.html
• [Remarks] Kanazawa University Research Bulletin
  • URL: http://www.kanazawa-u.ac.jp/research_bulletin/highlights201302H016.html
• [Remarks] tt Lab-金沢大学 糖尿病・内分泌代謝研究室 (1内1研)
  • URL: https://www.facebook.com/TakamuraLab