CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity

• Project/Area Number: 23591304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Shiga University of Medical Science
• Principal Investigator: UGI Satoshi 滋賀医科大学, 医学部, 講師 (20378483)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 内臓脂肪 / アジポサイトカイン / メタボリックシンドローム / metabolic syndrome / 脂肪生検

Research Abstract

To search for novel markers of visceral adiposity, visceral and subcutaneous adipose tissues were obtained from 43 Japanese men. We conducted microarray analysis using RNA from visceral and subcutaneous adipose tissues obtained from five men with abdominal obesity and five non-obese men. The mRNA expression of CCDC3 (encoding coiled-coil domain-containing protein 3) was upregulated in omental adipose tissues from abdominally obese subjects (3.07-fold) but not in subcutaneous adipose tissues (0.89-fold). Similar expression patterns were found in two distinct mouse models of obesity. In the analysis of all 43 men, CCDC3 mRNA levels in omental, but not in subcutaneous adipose tissue, were positively correlated with waist circumference and BMI. CCDC3 was predicted to be a secretory protein, which was confirmed by western blotting.
These results suggest that CCDC3 is a potential biomarker for estimating visceral adiposity.

Research Products

• [Journal Article] CCDC3 is specifically upregulated in omental adipose tissue in subjects with abdominal obesity. (2014)
  • Author(s): Satoshi Ugi, Shiro Maeda, Yoshihiro Kawamura, Masa-aki Kobayashi, Minako Imamura, Takeshi Yoshizaki, Katsutaro Morino, Osamu Sekine, Hiroshi Yamamoto, Toru Tani, Masatomo Rokushima, Atsunori Kashiwagi, Hiroshi Maegawa
  • Journal Title: Obesity Volume: 22 Issue: 4 Pages: 1070-1077
  • DOI: 10.1002/oby.20645
  • Peer Reviewed
• [Book] 新たなメタボリックシンドローム発症遺伝子同定のための網羅的研究ヒト生検脂肪組織マイクロアレイ解析と全ゲノムSNP解析を用いて, Therapeutic Research (2011)
  • Author(s): 卯木智,西尾善彦,他7名
  • Publisher: (32巻6号)