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Role of TBP-2 of pancreatic B cells in glucose intolerance

Research Project

Project/Area Number 23591308
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKochi University

Principal Investigator

FUJIMOTO Shimpei  高知大学, 教育研究部医療学系, 教授 (00333576)

Co-Investigator(Kenkyū-buntansha) INAGAKI Nobuya  京都大学, 医学研究科, 教授 (30241954)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsTBP-2 / 糖尿病 / B細胞 / 膵B細胞 / TBP-2
Research Abstract

This study was designed to elucidate in vivo regulation of thioredoxin-binding protein 2 (TBP-2) and roles of TBP-2 in glucose intolerance. Disruption of TBP-2 in whole body ameliorates glucose level in ob/ob mouse, a model of obese diabetes. In B cell-specific TBP-2 transgenic mice, generated in this study, glucose tolerance was not altered, but B cell area was reduced, which suggests a role of TBP-2 in regulation of B cell mass. Treatment of ob/ob mice by hypoglycemic agents and high fat diet on normal mice reveled that hyperglycemia, not obese induced by high fat diet, plays a role in overexpression of TBP-2 in B cells in vivo.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 11 results) Presentation (18 results)

  • [Journal Article] Palmitate induces reactive oxygen species production andβ-cell dysfunction by activating NADPH oxidase via Src signaling2014

    • Author(s)
      Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Inagaki N
    • Journal Title

      J Diabetes Investig

      Volume: 5 Issue: 1 Pages: 19-26

    • DOI

      10.1111/jdi.12124

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction2013

    • Author(s)
      Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
    • Journal Title

      Diabetes

      Volume: 62 Issue: 6 Pages: 1996-2003

    • DOI

      10.2337/db12-0903

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tetrahydro biopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase- dependent manner in diabetic mice2013

    • Author(s)
      Abudukadier A, Fujita Y, Obara A, Ohashi A, Fukushima T, Sato Y, Ogura M, Nakamura Y, Fujimoto S, Hosokawa M, Hasegawa H, Inagaki N
    • Journal Title

      Diabetes

      Volume: 62 Issue: 9 Pages: 3033-3043

    • DOI

      10.2337/db12-1242

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury2013

    • Author(s)
      Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Terada Y
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 305(4) Issue: 4 Pages: 495-509

    • DOI

      10.1152/ajprenal.00642.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 酸化ストレスと膵β細胞機能2013

    • Author(s)
      田原裕美子、藤本新平、稲垣暢也
    • Journal Title

      Diabetes Frontier

      Volume: 24 Pages: 527-232

    • URL

      http://www.m-review.co.jp/

    • Related Report
      2013 Final Research Report
  • [Journal Article] Upregulation of HNF-1β during experimental acute kidney injury plays a crucial role in renal tubule regeneration.2012

    • Author(s)
      Ogata K,Inoue K,et al
    • Journal Title

      10.1152/ajprenal.00086

      Volume: 303 Issue: 5 Pages: 689-699

    • DOI

      10.1152/ajprenal.00086.2012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver X receptorαis involved in the transcriptional regulation of the 6-phosphofructo-2- kinase/fructose-2,6-bisphosphatase gene2012

    • Author(s)
      Zhao LF, Iwasaki Y, Nishiyama M, Taguchi T, Tsugita M, Okazaki M, Nakayama S, Kambayashi M, Fujimoto S, Hashimoto K, Murao K, Terada Y
    • Journal Title

      Diabetes

      Volume: 61 Issue: 5 Pages: 1062-1071

    • DOI

      10.2337/db11-1255

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-12011

    • Author(s)
      Nishi Y, Fujimoto S, Sasaki M, Mukai E, Sato H, Sato Y, Tahara Y, Nakamura Y, Inagaki N
    • Journal Title

      Biochem J

      Volume: 435 Issue: 2 Pages: 421-430

    • DOI

      10.1042/bj20101708

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic βcells: a simulation study2011

    • Author(s)
      Cha CY , Nakamura Y, Himeno Y, Wang J,Fujimoto S, Inagaki N, Earm YE, Noma A
    • Journal Title

      J Gen Physiol

      Volume: 138(1)巻 Issue: 1 Pages: 21-37

    • DOI

      10.1085/jgp.201110611

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Systems Analysis of GLP-1 Receptor Signaling in Pancreatic {beta}-cells2011

    • Author(s)
      Takeda Y, Amano A, Noma A, Nakamura Y, Fujimoto S, Inagaki N
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 301(4) Issue: 4 Pages: C792-C803

    • DOI

      10.1152/ajpcell.00057.2011

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of endogenous ROS production in impaired metabolism-secretion coupling of diabetic pancreaticβcells2011

    • Author(s)
      Fujimoto S, Mukai E, Inagaki N
    • Journal Title

      Prog Biophys Mol Biol

      Volume: 107 Issue: 2 Pages: 304-310

    • DOI

      10.1016/j.pbiomolbio.2011.07.013

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of impaired metabolism-secretion coupling in diabetic pancreaticβcells2011

    • Author(s)
      Fujimoto S
    • Journal Title

      Diabetol Int

      Volume: 2 Issue: 3 Pages: 122-126

    • DOI

      10.1007/s13340-011-0040-0

    • Related Report
      2013 Final Research Report
  • [Journal Article] Targetingβ-cell functions in therapy for type 2d iabetes2011

    • Author(s)
      Fujimoto S, Inagaki N
    • Journal Title

      J Diabetes Investig

      Volume: 2 Issue: 3 Pages: 178-179

    • DOI

      10.1111/j.2040-1124.2011.00117.x

    • Related Report
      2013 Final Research Report
  • [Journal Article] 2型糖尿病のインスリン分泌障害において膵β細胞の機能低下あるいはmassの減少のどちらが重要なのか?2011

    • Author(s)
      藤本新平、稲垣暢也
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 32 Pages: 399-401

    • NAID

      40018869236

    • URL

      http://www.kahyo.com/

    • Related Report
      2013 Final Research Report
  • [Journal Article] Exendin-4 suppresses SRC activity and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner2010

    • Author(s)
      Mukai E, Fujimoto S, Sato H, Oneyama C, Kominato R, Sato Y, Sasaki M, Nishi Y, Okada M, Inagaki N
    • Journal Title

      Diabetes

      Volume: 60(1) Issue: 1 Pages: 218-226

    • DOI

      10.2337/db10-0021

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] グルコースによるインスリン分泌動態惹起経路と増幅経路

    • Author(s)
      藤本新平
    • Journal Title

      日本臨床

      Volume: 70増刊(最新臨床糖尿病学) Pages: 104-108

    • URL

      http://www.nippon-rinsho.co.jp/

    • Related Report
      2013 Final Research Report
  • [Presentation] Palmitate induces ROS production andβ-cell dysfunction by activating NADPH oxidase via Src signaling, American Diabetes Association2013

    • Author(s)
      Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Seino Y, Inagaki N
    • Organizer
      73rd Scientific Sessions
    • Place of Presentation
      Moscone Center, Chicago, IL, USA
    • Year and Date
      2013-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] リンゴ由来プロシアニジン類による糖尿病モデルマウスにおける抗糖尿病作用の検討2013

    • Author(s)
      小倉かさね、藤本新平、稲垣暢也(他9名)
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本他、熊本市
    • Year and Date
      2013-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Srcはグルコキナーゼ活性調節を介して膵β細胞グルコース応答性インスリン分泌に関与する2013

    • Author(s)
      佐藤広規、藤本新平、稲垣暢也(他9名)
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本他、熊本市
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Thioredoxin binding protein-2(TBP- 2)が膵β細胞で果たす役割についての検討2013

    • Author(s)
      田原裕美子、藤本新平、稲垣暢也(他9名)
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本他、熊本市
    • Year and Date
      2013-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Palmitate induces ROS production and β-cell dysfunction by activating NADPH oxidase via Src signaling2013

    • Author(s)
      Sato Y, Fujimoto S, Mukai E, Sato H, Tahara Y, Ogura K, Yamano G, Ogura M, Nagashima K, Seino Y, Inagaki N
    • Organizer
      American Diabetes Association, 73rd Scientific Sessions
    • Place of Presentation
      McCormick Place, Chicago, IL, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Persistent reduction of ROS ameliorates metabolism-secretion coupling in cultured diabetic GK Islets by suppressing Warburg effect2012

    • Author(s)
      Sasaki M, Fujimoto S, Nishi Y, Mukai E, Yamano G, Sato Y, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
    • Organizer
      American Diabetes Association, 72nd Scientific Sessions
    • Place of Presentation
      McCormick Place Convention Center, Philadelphia, PA, USA
    • Year and Date
      2012-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 活性酸素種抑制によるWarburg効果改善を介するGKラットインスリン分泌障害改善効果癌代謝類似代謝障害制御の重要性2012

    • Author(s)
      佐々木真弓、藤本新平、稲垣暢也(他8名)
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Persistent reduction of ROS ameliorates metabolism-secretion coupling in cultured diabetic GK Islets by suppressing Warburg effect2012

    • Author(s)
      Sasaki M, Fujimoto S, Nishi Y, Mukai E, Yamano G, Sato Y, Sato H, Tahara Y, Ogura K, Nagashima K, Inagaki N
    • Organizer
      American Diabetes Association, 72nd Scientific Sessions
    • Place of Presentation
      McCormic Place Convention Center, Philadelphia, PA, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Metabolic dysfunction in diabetes : Metabolic pathways at the crossroads of diabetes and cancer2011

    • Author(s)
      Fujimoto S
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      ヒルトン東京ベイ,Tokyo, Japan
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired insulin secretion due to mitochondrial dysfunction in diabetes2011

    • Author(s)
      Fujimoto S
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      ヒルトン東京ベイ,Tokyo, Japan
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of endogenous ROS production in amelioration of impaired metabolism-secretion coupling of diabetesβ-cells by augmentation of GLP-1 signals2011

    • Author(s)
      Fujimoto S, Mukai E, Inagaki N
    • Organizer
      Asia Islet Biology & Incretin Symposium (AIBIS) 2011
    • Place of Presentation
      Crowne Plaza, Beijing, China
    • Year and Date
      2011-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖尿病における膵β細胞代謝-分泌連関障害の分子機構2011

    • Author(s)
      藤本新平
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      さっぽろ芸術文化の館、札幌市(受賞講演1(リリー賞))
    • Year and Date
      2011-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of endogenous ROS production in metabolism-secretion coupling of pancreaticβ-cells2011

    • Author(s)
      Fujimoto S, Mukai E, Inagaki N
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌、札幌市
    • Year and Date
      2011-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Impaired insulin secretion due to mitochondrial dysfunction in diabetes2011

    • Author(s)
      Fujimoto S
    • Organizer
      Croucher Foundation Advance Study Institute (ASI) on"Mitochondrial Stress in Diabetes and Aging"
    • Place of Presentation
      Mrs Chen Yang Foo Oi Telemedicine Centre, Hong Kong, China
    • Year and Date
      2011-04-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 平成23年度糖尿病学会賞(リリー賞)受賞講演:糖尿病における膵β細胞代謝-分泌連関障害の分子機構

    • Author(s)
      藤本新平
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      さっぽろ芸術文化の館(北海道札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム(英語):Role of endogenous ROS production in metabolism-secretion coupling of pancreatic β-cells

    • Author(s)
      Fujimoto S, Mukai E, Inagaki N
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Metabolic dysfunction in diabetes: Metabolic pathways at the crossroads of diabetes and cancer

    • Author(s)
      Fujimoto S
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      ヒルトン東京ベイ(千葉県浦安市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Impaired insulin secretion due to mitochondrial dysfunction in diabetes

    • Author(s)
      Fujimoto S
    • Organizer
      The 16th Japan-Korea Symposium on Diabetes Mellitus
    • Place of Presentation
      ヒルトン東京ベイ(千葉県浦安市)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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