| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
This study was designed to elucidate in vivo regulation of thioredoxin-binding protein 2 (TBP-2) and roles of TBP-2 in glucose intolerance. Disruption of TBP-2 in whole body ameliorates glucose level in ob/ob mouse, a model of obese diabetes. In B cell-specific TBP-2 transgenic mice, generated in this study, glucose tolerance was not altered, but B cell area was reduced, which suggests a role of TBP-2 in regulation of B cell mass. Treatment of ob/ob mice by hypoglycemic agents and high fat diet on normal mice reveled that hyperglycemia, not obese induced by high fat diet, plays a role in overexpression of TBP-2 in B cells in vivo.
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