Regeneration of pancreatic beta-cell from pancreatic SP cell
| Project/Area Number |
23591309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyushu University |
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Principal Investigator |
KATSUTA HITOSHI 九州大学, 医学(系)研究科(研究院), 講師 (50333240)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAFUCHI Seiho 九州大学, 医学(系)研究科(研究院), 教授 (00150441)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵ベータ細胞 / 再生医療 / 糖尿病 |
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| Outline of Final Research Achievements |
To conquer type 1 diabetes, many efforts have been made to regenerate pancreatic beta-cells from a variety of cells including the pluripotent stem cells, such as ES cells and iPS cells but we have not yet succeeded to get fully functional pancreatic beta-cells enough to clinical use. In this study, we have tried to identify substances which induce insulin-producing cells from pancreatic SP cells that are considered pancreatic stem cells.
In this study, we have succeeded to pick up several substances that induced insulin-producing cells from pancreatic SP cells. These results will give an important basis for the development of pancreatic β cell regenerative therapy using pancreatic stem cells.
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Report
(5 results)
Research Products
(10 results)
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[Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.2015
Author(s)
Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.2013
Author(s)
El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN
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Journal Title
Cell Rep
Volume: 21;3(2)
Issue: 2
Pages: 401-10
DOI
Related Report
Peer Reviewed
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[Journal Article] Birth and death of human β-cells in pancreas from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.2013
Author(s)
Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC.
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Journal Title
Cell Transplant
Volume: Epub ahead of print
Related Report
Peer Reviewed
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