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Regeneration of pancreatic beta-cell from pancreatic SP cell

Research Project

Project/Area Number 23591309
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionKyushu University

Principal Investigator

KATSUTA HITOSHI  九州大学, 医学(系)研究科(研究院), 講師 (50333240)

Co-Investigator(Kenkyū-buntansha) NAGAFUCHI Seiho  九州大学, 医学(系)研究科(研究院), 教授 (00150441)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords膵ベータ細胞 / 再生医療 / 糖尿病
Outline of Final Research Achievements

To conquer type 1 diabetes, many efforts have been made to regenerate pancreatic beta-cells from a variety of cells including the pluripotent stem cells, such as ES cells and iPS cells but we have not yet succeeded to get fully functional pancreatic beta-cells enough to clinical use. In this study, we have tried to identify substances which induce insulin-producing cells from pancreatic SP cells that are considered pancreatic stem cells.
In this study, we have succeeded to pick up several substances that induced insulin-producing cells from pancreatic SP cells. These results will give an important basis for the development of pancreatic β cell regenerative therapy using pancreatic stem cells.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes.2015

    • Author(s)
      Izumi K, Mine K, Inoue Y, Teshima M, Ogawa S, Kai Y, Kurafuji T, Hirakawa K, Miyakawa D, Ikeda H, Inada A, Hara M, Yamada H, Akashi K, Niho Y, Ina K, Kobayashi T, Yoshikai Y, Anzai K, Yamashita T, Minagawa H, Fujimoto S, Kurisaki H, Shimoda K, Katsuta H, Nagafuchi S.
    • Journal Title

      Nat Commun.

      Volume: 6 Issue: 1 Pages: 1-10

    • DOI

      10.1038/ncomms7748

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TYK2 Promoter Variant and Diabetes Mellitus in the Japanese2015

    • Author(s)
      Seiho Nagafuchi; Yumi Kamada-Hibio; Hitoshi Katsuta, et.al.
    • Journal Title

      E-Biomedicine

      Volume: 未定

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.2013

    • Author(s)
      El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN
    • Journal Title

      Cell Rep

      Volume: 21;3(2) Issue: 2 Pages: 401-10

    • DOI

      10.1016/j.celrep.2013.01.007

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Birth and death of human β-cells in pancreas from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice.2013

    • Author(s)
      Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC.
    • Journal Title

      Cell Transplant

      Volume: Epub ahead of print

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subpopulations of GFP-marked mouse pancreatic β-cells differ in size, granularity, and insulin secretion.2012

    • Author(s)
      Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC.
    • Journal Title

      Endocrinology

      Volume: 153(11) Issue: 11 Pages: 5180-7

    • DOI

      10.1210/en.2012-1257

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] ウイルス糖尿病:疾患感受性遺伝子の解明2014

    • Author(s)
      勝田 仁
    • Organizer
      糖尿病 Expert Seminar
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ウイルス糖尿病誘発性と宿主の感受性2014

    • Author(s)
      永淵 正法
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ウイルス誘発糖尿病におけるTyk2遺伝子の意義2012

    • Author(s)
      手嶋 美穂, 甲斐 裕次, 甲斐 克也, 三根 敬一朗, 和泉 賢一, 栗崎 宏憲, 勝田 仁, 永淵 正法
    • Organizer
      日本臨床ウイルス学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2012 Research-status Report
  • [Presentation] ナノコートディッシュ培養マウス由来ES細胞の未分化能の検討2012

    • Author(s)
      中島 紫, 永淵 正法, 勝田 仁, 原口 和敏
    • Organizer
      日本糖尿病学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Research-status Report
  • [Remarks] 九州大学大学院 医学系学府

    • URL

      http://www.shs.med.kyushu-u.ac.jp/

    • Related Report
      2014 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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