| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
In order to examine the clinical significance of ZnT8 autoantibodies in type 1 diabetes, six ZnT8/ZnT3 chimeric cDNA were created and ZnT8 autoantibody epitopes were analyzed. As a result, the carboxy-terminal 10 amino acid residues in ZnT8 contribute to conformational epitope(s) that is associated with acute-onset and younger-onset type 1 diabetes.
Although prevalence of ZnT8 autoantibodies was higherin acute-onset or younger-onset patients at disease onset, it persisted in adult-onsetpatients.
Furthermore, we have evaluated a newly developed ZnT8 autoantibody ELISA.
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